Thyroid Hormones and Prolactin Levels in Infertile Women in Southern Nigeria

Bassey, Iya Eze; Udoh, A. E.; Essien, Okon; Isong, Idongesit Kokoabasi; Gali, Rebecca Mtaku; Archibong, E. E.

doi:10.7860/jcdr/2015/11505.5659

Cited by 13 publications

(17 citation statements)

References 10 publications

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“…This indicates that T 4 when changed into T 3 inside pituitary cells has a negative feedback effect in TSH release. 8 Non-significant positive correlation was observed between TSH and age (r = 0.077, p = 0.631) which was supported from previous studies that the level of TSH increases with the progress of age. 20 Raised TSH level in higher age groups may be due to the increase levels of TPO-Ab (Thyroid peroxidase antibodies) titer among infertile women.…”

Section: Resultssupporting

confidence: 73%

“…6,7 Infertility is of two types: If a female is unable to conceive in spite of regular cohabitation then it is termed as primary infertility while secondary infertility is because of any factor in which if a female has conceived at least once but unable to pregnant again. 8 Several studies have confirmed that primary infertility is more prevalent globally. 9,10 WHO has reported that 35% cases of infertility are due to female factors, 30% due to male factor and in 20% cases both are involved while 15% cases are idiopathic in nature.…”

Section: Introductionmentioning

confidence: 99%

“…The release of progesterone from granulosa cells takes place only when thyroid hormone acts along with FSH, LH and Hcg. 8,25 It has been evaluated by several studies that thyroid hormone controls reproductive cycle by two ways: either it affects ovaries directly or may acts indirectly with the help of sex hormone binding globulin. 26,27 Infertility is considered as a multifactorial problem and has been deliberated as a worldwide public health issue.…”

Section: Introductionmentioning

confidence: 99%

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Thyroid Disorders;

Rahman

Saeed

Zia

et al. 2019

TPMJ

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Infertility has been considered as a worldwide global health issue. It is a human nature that every couple wants to have children so that the relationship can become stronger. Defect in thyroid hormone levels is one of the factors which can lead to reproductive cycle disorders and thus infertility results. Objectives: The purpose of current study was to investigate the levels of thyroid hormones in primary infertile and fertile females in order to evaluate the prevalence of thyroid disordsers. Study Design: Case control study. Place of Study: Outdoor of gynecology department of Madinah Teaching Hospital, Faisalabad. Duration of Study: 6 months from July to December 2017. Material and Methods: The study enrolled total 91 females of reproductive age 20-35 years which included 45 primary infertile females and 46 fertile females. They were divided into two groups. Group I: case/primary infertile women group (n= 45) and Group II: control /fertile females group (n= 46). Data was collected by taking history and clinical examination. Hormonal profile including fT3, fT4 and TSH was done by means of chemiluminescentimmunoassay. Results were analyzed by using SPSS version 20. Results: Most of the infertile females were euthyroid and hyperthyroidism was the most common thyroid disorder. The prevalence of hypothyroidism and hyperthyroidism was about 9.3% and 26.7% respectively. The p-value showed the non-significant difference in the levels of fT3, fT4 and TSH between primary infertile and fertile females.Significant positive correlation between fT3 and fT4 while non-significant negative correlation was observed between fT3 & TSH and fT4& TSH in primary infertile females. Conclusion: Infertile females with menstrual irregularities should be advised thyroid profile in order to avoid other unnecessary investigations. Evaluation of thyroid status in the infertile couple is not only important but also easy because its treatment is very simple and often has revocable effects on subfertility.

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Section: Resultssupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Thyroid Disorders;

Rahman

Saeed

Zia

et al. 2019

TPMJ

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“…Однако не было никакой корреляции между содержанием ПРЛ и ТТГ, T3 и T4 в обеих группах женщин с бесплодием. Авторы делают вывод о том, что гиперпролактинемия с дисфункцией ЩЖ может быть основным фактором, способствующим бесплодию, и, следовательно, оценка показателей ПРЛ, Т3, Т4 и ТТГ должна быть включена в исследование бесплодных женщин, особенно с гиперпролактинемией [12]. P. Bheem и соавт.…”

Section: таблицаunclassified

Thyroid-Stimulating Hormone and Prolactin Levels in a Population-based Sample of Women Aged 25 to 45

Рымар¹,

Voevoda²,

Денисова³

et al. 2019

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Цель исследования: изучить уровни тиреотропного гормона (ТТГ) и пролактина (ПРЛ) и их ассоциации в популяционной выборке женщин в возрасте 25-45 лет. Дизайн: поперечное исследование. Материалы и методы. Обследована репрезентативная выборка женщин 25-45 лет. Средний возраст участниц-36,0 ± 6,2 года. У 416 женщин методом иммуноферментного анализа определены уровни ПРЛ и ТТГ. Результаты. Медиана ТТГ обследованных женщин составила 1,48 [0,98; 2,19] МЕ/мл, ПРЛ-12,13 [6,75; 18,85] нг/мл. Статистически значимая разница между значениями медиан ТТГ и ПРЛ в 4 возрастных подгруппах (25-29, 30-34, 35-39 и 40-45 лет) не обнаружена: р = 0,559, р = 0,197 (Н-критерий Краскела-Уоллеса). У женщин без нарушения менструального цикла и патологии щитовидной железы (ЩЖ) медиана ТТГ-1,49 [1,02; 2,06] МЕ/мл, ПРЛ-10,79 [5,92; 17,12] нг/мл, а при нарушении менструального цикла и/или патологии ЩЖ-1,43 [0,86; 2,63] МЕ/мл и 14,34 [8,54; 21,35] нг/мл соответственно; разница между показателями ПРЛ статистически значима (p = 0,001). Определена тенденция к повышению уровня ТТГ (в пределах нормальных значений) в квартилях ПРЛ, несмотря на значительный рост медианы ПРЛ от первого квартиля к четвертому (4,51 [3,56; 5,48]-24,38 [21,33; 30,45]): р = 0,078. Отмечена статистически значимая разница между показателями ТТГ в квартилях ПРЛ (Н-критерий Краскела-Уоллеса): р = 0,044. Во всей выборке обнаружена слабая корреляция между уровнями ТТГ и ПРЛ: коэффициент корреляции по Спирмену (r) составил 0,09, р = 0,067. Выявлен более высокий процент пациенток с повышенным содержанием ПРЛ и ТТГ среди женщин, указавших на нарушения менструального цикла, чем среди женщин без них, хотя разница оказалась статистически незначимой. Заключение. Среди женщин с нарушениями менструального цикла и без них процент пациенток с повышенным уровнем ПРЛ больше, чем с повышенным содержанием ТТГ. Можно отметить, что гиперпролактинемия нередка у молодых женщин с нарушениями менструального цикла. По результатам проведенного скринингового исследования планируется дальнейшее обследование женщин для выявления причин гиперпролактинемии и проведения соответствующего лечения. Ключевые слова: пролактин, тиреотропный гормон, нарушение менструального цикла.

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“…These findings are in accordance with the results of a study showed that there was a higher prevalence of hyperprolactinemia which positively correlated with thyroid disorder in infertile women (Goswami et al, 2009). In a recent study, Bassey et al (2015) concluded that hyperprolactinemia with thyroid dysfunction may be a major contributor hormonal factor in infertility among infertile women. In addition, both groups showed significant correlation between prolactin and other hormones, including LH, FSH, prolactin, testosterone, estradiol and progesterone (Table 4).…”

mentioning

confidence: 99%

Correlation of Prolactin With Thyroid-Stimulating Hormone and Female Sex Hormones in Infertile Women.

Atrooz¹,

Alghonmeen²,

Abukhalil.³

2017

IJAR

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Hormonal and biochemical disturbances play an important role in development of infertility cases. Therefore, this study was conducted to evaluate the prolactin level and to explore the association between prolactin and thyroid stimulating hormone (TSH) and other hormones in the diagnosed infertile women in Ma'an governorate. The study was performed on 151 women (age group 20-40 years) who visited the Gynecology and Obstetrics Department at Ma'an governmental hospital. The study sample was divided into three groups: fertile group (n= 27), primary infertile group (n= 82) and secondary infertile group (n= 42). The results showed high incidence of prolactin abnormalities in both primary and secondary infertile women (90% and 92%, respectively). Furthermore, TSH abnormalities were found in 90% of primary infertile and % 93 of secondary infertile women. In addition, the results revealed the positively significant correlation between TSH and the fertility. Positive correlations were found between the levels of prolactin and TSH in primary and secondary infertility. Also, there were positive correlations between the levels of prolactin and other hormones, including luteinizing hormone, follicle-stimulating hormone, testosterone, estradiol and progesterone. In conclusion, the present study revealed a significant correlation between prolactin and TSH and other hormones in infertile women. Therefore, assessment of serum TSH and prolactin levels are mandatory in the work up of all infertile women, especially those presenting with menstrual irregularities.

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Thyroid Hormones and Prolactin Levels in Infertile Women in Southern Nigeria

Cited by 13 publications

References 10 publications

Thyroid Disorders;

Thyroid Disorders;

Thyroid-Stimulating Hormone and Prolactin Levels in a Population-based Sample of Women Aged 25 to 45

Correlation of Prolactin With Thyroid-Stimulating Hormone and Female Sex Hormones in Infertile Women.

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