Thyroid Hormones and Their Relation to Weight Status

Reinehr, Thomas; Isa, Adelbert; Sousa, Gideon de; Dieffenbach, Rainer; Andler, Werner

doi:10.1159/000129678

Cited by 162 publications

(175 citation statements)

References 68 publications

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“…Contrasting results were reported by other authors who did not detect any association between TSH levels and HOMA-IR (5,14).…”

Section: δBmc-sdscontrasting

confidence: 99%

“…Leptin stimulates TSH production acting through the hypothalamic-pituitary axis (3,9,17). It has been recently reported that leptin signaling, mediated by JAK/STAT pathway, is mandatory for the maintenance of TRH expression in the hypothalamic paraventricular nucleus and thus, for normal production of TSH and thyroid hormones (9,11,14,17,28). This finding is corroborated by our results, as our obese patients with hyperthyrotropinemia showed significantly higher fT3 values.…”

Section: Discussionsupporting

confidence: 90%

“…This result may be the reason why the studied biochemical parameters remained unchanged overall (Table 4). Like several other studies (4,13,14,17,30) we did not find an association between BMI-SDS variation and TSH, even after substantial weight loss (BMI-SDS variation ≤ -0.5).…”

Section: δBmc-sdssupporting

confidence: 71%

“…Obese children may have moderately elevated TSH levels in association with normal or slightly elevated free thyroxine (fT4) and/or free triiodothyronine (fT3) levels, suggesting an adaptation process for increasing energy expenditure (1). Increased TSH levels, in obese children, have been reported to normalize after substantial weight loss, but no overall consensus has been reached (1,3,9,(14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

“…Some studies report that obese children with high TSH levels have more severe insulin resistance than obese children with normal TSH levels, with HOMA-IR positively correlating with TSH levels (5,16). Some authors attribute this relationship to weight variation and not to thyroid function (1,14).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Childhood obesity, thyroid function, and insulin resistance – is there a link? A longitudinal study

Santos

Limbert

Marquês

et al. 2015

Journal of Pediatric Endocrinology and Metabolism

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Background: Serum thyroid stimulating hormone (TSH) levels are frequently elevated in obese children and are most likely to be associated with insulin resistance. However, clinical relevance of this association remains unclear. Objectives: To assess the prevalence of hyperthyrotropinemia; to analyze the relationship between TSH and homeostasis model assessment -insulin resistance (HOMA-IR); and to verify whether TSH levels and HOMA-IR vary with weight loss in obese children. Subjects and Methods: Retrospective longitudinal study with data from baseline and 1 year after lifestyle intervention in a pediatric obese group (344 children were recruited and 100 among them completed follow-up). For postintervention analysis, three groups were considered according to body mass index-standard deviation score (BMI-SDS) variations: ≤ -0.5 (significant weight loss); 0.5-0 (weight loss); and > 0 (weight gain). Statistical analysis was performed using SPSS 19.0

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“…Contrasting results were reported by other authors who did not detect any association between TSH levels and HOMA-IR (5,14).…”

Section: δBmc-sdscontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 90%

Section: δBmc-sdssupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Childhood obesity, thyroid function, and insulin resistance – is there a link? A longitudinal study

Santos

Limbert

Marquês

et al. 2015

Journal of Pediatric Endocrinology and Metabolism

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Hypothyroidism due to Hashimoto's thyroiditis masked by anorexia nervosa

Smalls‐Mantey

Steinglass

Primack

et al. 2015

Intl J Eating Disorders

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Anorexia nervosa (AN) is typically associated with altered thyroid function tests, notably a low total and free T3 , and lower, but within normal range, free T4 and TSH. A 16-year-old girl with a four-year history of AN presented with elevated TSH that fluctuated with changes in weight. TSH was within normal limits (1.7-3.64 mIU/L) following periods of weight loss and elevated with weight gain (5.9-21.66 mIU/L). Antithyroperoxidase antibodies were markedly elevated, suggesting chronic Hashimoto's thyroiditis. Of note, the elevated TSH that would be expected in Hashimoto's thyroiditis was blunted by weight loss associated with AN. Physicians should be aware that AN may contribute to masking thyroid abnormalities in Hashimoto's thyroiditis.

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Body size and risk of differentiated thyroid carcinomas: Findings from the EPIC study

Rinaldi

Lise

Clavel‐Chapelon

et al. 2012

Intl Journal of Cancer

112

103

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Results from case-control and prospective studies suggest a moderate positive association between obesity and height and differentiated thyroid carcinoma (TC). Little is known on the relationship between other measures of adiposity and differentiated TC risk. Here, we present the results of a study on body size and risk of differentiated TC based on a large European prospective study (EPIC). During follow-up, 508 incident cases of differentiated TC were identified in women, and 58 in men. 78% of cases were papillary TC. Cox proportional hazard models were used to estimate hazard ratios (HRs). In women, differentiated TC risk was significantly associated with body mass index (BMI, kg/m 2 ) (HR highest vs lowest quintile 5 1.41, 95% CI: 1.03-1.94); height (HR 5 1.61; 95% CI: 1.18-2.20); HR highest vs lowest tertile waist (HR 5 1.34, 95% CI: 1.00-1.79) and waist-to-hip ratio (HR 5 1.42, 95% CI: 1.05-1.91). The association with BMI was somewhat stronger in women below age 50. Corresponding associations for papillary TC were similar to those for all differentiated TC. In men the only body size factors significantly associated with differentiated TC were height (non linear), and leg length (HR highest vs. lowest tertile 5 3.03, 95% CI: 1.30-7.07). Our study lends further support to the presence of a moderate positive association between differentiated TC risk and overweight and obesity in women. The risk increase among taller individuals of both sexes suggests that some genetic characteristics or early environmental exposures may also be implicated in the etiology of differentiated TC.

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Thyroid Hormones and Their Relation to Weight Status

Cited by 162 publications

References 68 publications

Childhood obesity, thyroid function, and insulin resistance – is there a link? A longitudinal study

Childhood obesity, thyroid function, and insulin resistance – is there a link? A longitudinal study

Hypothyroidism due to Hashimoto's thyroiditis masked by anorexia nervosa

Body size and risk of differentiated thyroid carcinomas: Findings from the EPIC study

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