Thyroid Peroxidase and Thyroglobulin Antibodies and Ophthalmopathy in Patients with Graves’ Disease, Hashimoto Thyroiditis and Transient Thyroiditis

Wall, Jack R.

doi:10.24966/he-9640/100002

Cited by 1 publication

(2 citation statements)

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“…This model included several risk factors and showed that subjects who had elevated Anti-TG values had a 21-times-higher probability of developing IOP elevation. Thyroglobulin (Tg) has been proposed to play a role in GO [ 34 , 35 , 36 ]. Polymorphisms in Tg, along with a combination of iodine and the enzymatic activity of thyroid peroxidase required for thyroid hormone synthesis, may unintentionally trigger an autoimmune response in the thyroid [ 36 , 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…Thyroglobulin (Tg) has been proposed to play a role in GO [ 34 , 35 , 36 ]. Polymorphisms in Tg, along with a combination of iodine and the enzymatic activity of thyroid peroxidase required for thyroid hormone synthesis, may unintentionally trigger an autoimmune response in the thyroid [ 36 , 37 , 38 ]. The involvement of Anti-TG in GO pathogenesis and their role as risk factor for IOP remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

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Correlation between Structural and Functional Changes in Patients with Raised Intraocular Pressure Due to Graves’ Orbitopathy

Bagatin,

Prpić,

Škunca Herman

et al. 2024

Diagnostics

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This study explores the complication of secondary intraocular pressure (IOP) elevation and consequent glaucoma development in Graves’ orbitopathy (GO), an autoimmune disorder associated with hyperthyroidism. Utilizing Octopus 900 visual field testing and optical coherence tomography (OCT), the research established correlations between functional and structural changes in optic nerve regions in patients with GO and patients with GO with elevated IOP (GO IOP) groups. A comparison with primary open-angle glaucoma (POAG) was conducted in a cohort of 182 subjects. The study identifies optic nerve head parameters that effectively differentiate changes in GO and GO IOP groups. In the GO group, the strongest correlation between structural and functional changes was observed in sector 7, while in the GO IOP group, it was in sectors 1 and 7. For POAG, correlation was found in six sectors. Elevated IOP in GO correlates with structural and functional impairments similarly to early glaucoma. Risk factors for GO-related elevated IOP included older age, longer duration of thyroid disease, and higher anti-thyroglobulin values. The study highlights the significance of regular IOP measurements, visual field assessments, and OCT examinations in GO patients. Early antiglaucoma intervention is warranted when characteristic structural and functional changes and/or risk factors are identified.

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