Thyroid transcription factor 1—a new prognostic factor in lung cancer: a meta-analysis

Berghmans, Thierry; Paesmans, Marianne; Mascaux, Céline; Martin, Benoı̂t; Meert, Anne-Pascale; Haller, Annick; Lafitte, Jean-Jacques; Sculier, Jean-Paul

doi:10.1093/annonc/mdl287

Cited by 122 publications

(124 citation statements)

References 23 publications

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“…Two other studies (Haque et al, 2002;Tan et al, 2003), evaluated stages I-IIIA NSCLCs with long-term follow-up and found that patients with strong Nkx2-1 expression had significantly better survival than patients with no Nkx2-1 (P=0.0067). A meta-analysis (Berghmans et al, 2006) using ten related studies published in the lung cancer literature showed that Nkx2-1 positivity was indeed significantly associated with better survival in NSCLC patients, and especially with early and locally advanced stages and in ADC.…”

Section: Prognostic Role Of Nkx2-1 In Lung Cancermentioning

confidence: 99%

“…In the advanced tumor stage, negative Nkx2-1 expression was an independent and significant marker for poor prognosis (Hiramatsu et al, 2010). Several other studies also evaluated the prognostic role of Nkx2-1 expression in NSCLC (Haque et al, 2002;Au et al, 2004;Berghmans et al, 2006), especially in lung ADC (Stenhouse et al, 2004;Barlési et al, 2005).…”

Section: Prognostic Role Of Nkx2-1 In Lung Cancermentioning

confidence: 99%

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Nkx2-1: a novel tumor biomarker of lung cancer

Lin

Ruan

et al. 2012

J. Zhejiang Univ. Sci. B

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Nkx2-1 (Nkx homeobox-1 gene), also known as TTF-1 (thyroid transcription factor-1), is a tissue-specific transcription factor of the thyroid, lung, and ventral forebrain. While it has been shown to play a critical role in lung development and lung cancer differentiation and morphogenesis, molecular mechanisms mediating Nkx2-1 cell-and tissue-specific expression in normal and cancerous lungs have yet to be fully elucidated. The recent identification of prognostic biomarkers in lung cancer, particularly in lung adenocarcinoma (ADC), and the different reactivity of patients to chemotherapeutic drugs have opened new avenues for evaluating patient survival and the development of novel effective therapeutic strategies. The function of Nkx2-1 as a proto-oncogene was recently characterized and the gene is implicated as a contributory factor in lung cancer development. In this review, we summarize the role of this transcription factor in the development, diagnosis, and prognosis of lung cancer in the hope of providing insights into the utility of Nkx2-1 as a novel biomarker of lung cancer.

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Section: Prognostic Role Of Nkx2-1 In Lung Cancermentioning

confidence: 99%

Section: Prognostic Role Of Nkx2-1 In Lung Cancermentioning

confidence: 99%

Nkx2-1: a novel tumor biomarker of lung cancer

Lin

Ruan

et al. 2012

J. Zhejiang Univ. Sci. B

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“…TTF-1 is highly sensitive and specific for the diagnosis of primary lung cancer. TTF-1 is a transcription factor that is specifically expressed in the thyroid and lungs, present in 60-70% of pulmonary adenocarcinomas; therefore, this marker is useful for distinguishing between primary and metastatic lesions [6,7]. ACC developing in the salivary glands is reported to exhibit a better prognosis than other pathological types of carcinoma occurring in the salivary glands, due to its slow growth and absence of metastasis until the late stages of tumor development [8].…”

Section: Discussionmentioning

confidence: 99%

Primary Adenoid Cystic Carcinoma of the Peripheral Lungs

Shinohara

Hanagiri

Takenaka

et al. 2015

J UOEH

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: We herein report a very rare case of adenoid cystic carcinoma of the peripheral lungs. A 77-year-old female visited a family physician for aortitis syndrome, diabetes mellitus and hyperlipidemia. A follow-up chest computed tomography scan for aortitis syndrome revealed a nodule in the middle lobe of the right lung. Although a transbronchial lung biopsy was attempted, a definitive diagnosis could not be made. Because the possibility of lung malignancy could not be ruled out, thoracoscopic wedge resection of the middle lobe was performed. The intraoperative pathological diagnosis revealed carcinoma of the lungs and we performed middle lobectomy under complete video-assisted thoracoscopic surgery. A histopathological examination demonstrated an adenoid cystic carcinoma with a characteristic cribriform structure.

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“…A peripheral tumor usually presents as a solitary pulmonary nodule/mass on plain films or chest CT. A rounded opacity with an irregular border (lobulation, notching and infiltrating edges) and cavitation within the mass are the signs of peripheral primary carcinoma [6]. Serum tumor markers, e.g., NKX2-1 (NKX homeobox-1 gene), also known as TTF-1 (thyroid transcription factor-1) can be considered as a transcription factor for development, diagnosis and prognosis of lung cancer [7]. Risk factors for the development of acute spontaneous tumor lysis syndrome in patients with nonhematological solid tumors include large tumor burden ([10 cm) with necrosis, rapidly proliferating tumor, extensive bone marrow involvement, hepatic metastasis, elevated white cell count ([50000/ll), elevated lactate dehydrogenase level, use of potentially nephrotoxic drugs and drugs which inhibit uric acid excretion, elevated uric acid level, impaired renal function, extrinsic compression of the urinary tract by the tumor, underlying problems such as dehydration, infection or urinary obstruction.…”

Section: Discussionmentioning

confidence: 99%

Concurrent acute spontaneous tumor lysis syndrome complicated with multiple organ failure in a patient with pre-existing undiagnosed lung cancer

Amiri

2015

CEN Case Rep

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Acute kidney injury, a common complication associated with malignancy, occurs in various clinical situations for numerous reasons. Acute tumor lysis syndrome (TLS) is possibly the most significant cause of acute kidney injury in cancer patients, because it is fulminant at onset and associated with severe metabolic derangements. Acute spontaneous tumor lysis syndrome is rare and most of the related malignancies belong to hematologic malignancies but it has seldom been investigated as bulky or advanced metastatic non-hematologic malignancies. TLS comprises a clinical laboratory derangement of cellular metabolism which can lead to acute renal impairments, cardiac arrhythmia, seizures and patient demise. Prevention and treatment of tumor lysis syndrome depends on early recognition of at-risk patients, volume repletion and xanthin oxidase inhibitors. In addition, in patients with high risk tumor types, prophylactic use of rasburicase before chemotherapy is required. If dialysis is required, continuous modalities may be favored, particularly in patients with more severe TLS. This case report discusses a 79-year-old man with controlled Alzheimer's disease presented with picture of septic shock and multiorgan dysfunction (acute kidney injury, acute lung injury, acute brain injury) pulmonary suppuration in the right lung field due to aspiration pneumonia with infection-induced systemic inflammatory response (SIRS) was diagnosed. Further workup revealed lung cancer on chest CT scan. Antibiotic, respirator and hemodialysis treatment improved his condition but died several days later. Acute spontaneous TLS may present in association with infectious SIRS and multiple organ failure, the combination of which results in significant mortality.

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Thyroid transcription factor 1—a new prognostic factor in lung cancer: a meta-analysis

Abstract: TTF-1 is a good prognostic factor for survival in NSCLC. Its effect appears also significant when the analysis is restricted to patients with adenocarcinoma. This study supports the fact that TTF-1 could be included in further prospective trials studying prognostic factors in NSCLC.

Cited by 122 publications

References 23 publications

Nkx2-1: a novel tumor biomarker of lung cancer

Nkx2-1: a novel tumor biomarker of lung cancer

Primary Adenoid Cystic Carcinoma of the Peripheral Lungs

Concurrent acute spontaneous tumor lysis syndrome complicated with multiple organ failure in a patient with pre-existing undiagnosed lung cancer

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