Thyroid ultrasound volume, structure and function after long-term high exposure of large population to polychlorinated biphenyls, pesticides and dioxin

Langer, P; Tajtáková, M; Kočan, Anton; Petrı́k, Ján; Koška, Juraj; Kšinantová, L; Rádiková, Žofia; Ukropec, Jozef; Imrich, Richard; Hučková, Miloslava; Chovancová, Jana; Drobná, Beata; Jursa, Stanislav; Vlček, Miroslav; Bergman, Anders; Athanasiadou, María; Hovander, Lotta; Shishiba, Yoshimasa; Trnovec, T.; Seböková, E; Klimeš, I

doi:10.1016/j.chemosphere.2007.04.039

Cited by 51 publications

(49 citation statements)

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“…Circulating lipids might significantly influence transport and tissue distribution of POPs. We previously reported significant association of PCBs, p,p′-DDE and HCB with circulating triacylglycerol and of p,p′-DDE and HCB with total cholesterol [21]. Similar an association of PCBs (∼600 ng/g) with triacylglycerol and cholesterol was recently found [35].…”

Section: Discussionsupporting

confidence: 68%

“…The same is true for levels of dioxins, furans and dioxin-like PCBs [16], as well as for OH-and MeSO 2 -metabolites [17]. Moreover, in the population of this area increased thyroid volume, prevalence of thyroid antibodies, disruption of thyroid hormone level and pituitary-thyroid interrelations have been found [18][19][20][21][22]. More recently, an increase in adverse health signs has been reported in adults [23] as well as in newborns, infants and school children of this area, e.g.…”

Section: Introductionmentioning

confidence: 62%

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High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail

et al. 2010

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Aims/hypothesis A heavily polluted area of Eastern Slovakia was targeted by the PCBRISK cross-sectional survey to search for possible links between environmental pollution and both prediabetes and diabetes. Methods Associations of serum levels of five persistent organic pollutants (POPs), namely polychlorinated biphenyls (PCBs), 2,2′-bis(4-chlorophenyl)-1,1-dichloroethylene (p,p′-DDE), 2,2′-bis(4-chlorophenyl)-1,1,1-trichloro-ethane (p,p′-DDT), hexachlorobenzene (HCB) and β-hexachlorocyclohexane (β-HCH), with prediabetes and diabetes were investigated in 2,047 adults. Diabetes and prediabetes were diagnosed by fasting plasma glucose in all participants and by OGTT in 1,220 compliant participants. Results Our population was stratified in terms of individual POPs quintiles and associations between environmental pollution, prediabetes and diabetes were investigated. Prevalence of prediabetes and diabetes increased in a dose-dependent manner, with individuals in upper quintiles of individual POPs showing striking increases in prevalence of prediabetes as shown by OR and 95% CI for PCBs (2.74; 1.92-3.90), DDE (1.86; 1.17-2.95), DDT (2.48; 1.77-3.48), HCB (1.86; 1.7-2.95) and β-HCH (1.97; 1.28-3.04). Interestingly, unlike PCBs, DDT and DDE, increased levels of HCB and β-HCH seemed not to be associated with increased prevalence of diabetes. Nevertheless, individuals in the 5th quintile of the variable expressing the cumulative effect of all five POPs (sum of orders) had a more than tripled prevalence of prediabetes and more than six times higher prevalence of diabetes when compared with the 1st referent quintile. Conclusions/interpretation Increasing serum concentrations of individual POPs considerably increased prevalence of prediabetes and diabetes in a dose-dependent manner. Interaction of industrial and agricultural pollutants in increasing prevalence of prediabetes or diabetes is likely.

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Section: Discussionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 62%

High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail

et al. 2010

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“…In brief, our initial sample group of 2047 adults was drawn from a population living in the Michalovce, Svidnik, and Stropkov districts in eastern Slovakia, an area known to be contaminated by a mixture of organochlorines (Jursa et al, 2006; Langer et al, 2007; Petrik et al, 2006; Wimmerová et al, 2015). Of the 2047 adults, 320 were willing to provide 90 mL of blood for analysis of PCDDs, PCDFs, and PCBs.…”

Section: Methodsmentioning

confidence: 99%

Relative effect potency estimates of dioxin-like activity for dioxins, furans, and dioxin-like PCBs in adults based on cytochrome P450 1A1 and 1B1 gene expression in blood

Wimmerová

Berg

Chovancová

et al. 2016

Environment International

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Background In the risk assessment of PCDDs, PCDFs, and dioxin-like (DL) PCBs, regulatory authorities support the use of the toxic equivalency factor (TEF)-scheme derived from a heterogeneous data set of the relative effect potency (REPs) estimates. Objectives We sought to determine REPs for dioxin-like compounds (DLCs) using expression of cytochrome P450 (CYP) 1A1 and 1B1 mRNA in human peripheral blood mononuclear cells representing two different pathways. Methods We used a sex and age adjusted regression-based approach comparing the strength of association between each DLC and the cytochrome P450 (CYP) 1A1 and 1B1 mRNA expression in 320 adults residing in an organochlorine-polluted area of eastern Slovakia. Results We calculated REPs based on CYP1A1 expression for 4 PCDDs, 8 PCDFs, and 1 PCB congener, and based on CYP1B1 expression for 5 PCDFs and 11 PCB congeners. REPs from CYP1A1 correlated with REPs previously derived from thyroid volume (ρ = 0.85; p < 0.001) and serum FT4 (ρ = 0.77; p = 0.009). The 13 log REPs from CYP1A1 correlated with log WHO-TEFs (r = 0.63; p = 0.015) and 11 log PCB REPs with PCB consensus toxicity factors (CTFs) for compounds with WHO-TEFs (r = 0.80; p = 0.003). The complete set of derived 56 log REPs correlated with the log CTFs (r = 0.77; p = 0.001) and log WHO-TEFs (r = 0.81; p < 0.001). Conclusions REPs calculated from thyroid and cytochrome P450 endpoints realistically reflect human exposure scenarios because they are based on human chronic and low-dose exposures. While the CYP 1A1 seems more suitable for toxicity evaluation of PCDD/Fs, the CYP 1B1 is more apt for PCDFs and PCBs and reflects different pathways.

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“…Interactions with dietary iodine intake may also exist [46]. A high exposure to polychlorinated biphenyls is also related to an increase in thyroid volume [47]. …”

Section: Discussionmentioning

confidence: 99%

Thyroid Volume and Its Relation to Anthropometric Measures in a Healthy Cuban Population

Turcios¹,

Lence-Anta²,

Santana³

et al. 2015

Eur Thyroid J

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Objectives: The aim of this study was to describe the thyroid volume in healthy adults by ultrasound and to correlate this volume with some anthropometric measures and other differentiated thyroid cancer risk factors. Study Design: Thyroid volume and anthropometric measures were recorded in a sample of 100 healthy adults, including 21 men and 79 women aged 18-50 years, living in a non-iodine-deficient area of Havana city. Results: The average thyroid volume was 6.6 ± 0.26 ml; it was higher in men (7.3 ml) than in women (6.4 ml; p = 0.15). In the univariate analysis, thyroid volume was correlated with all anthropometric measures, but in the multivariate analysis, body surface area was found to be the only significant anthropometric parameter. Thyroid volume was also higher in current or former smokers and in persons with blood group AB or B. Conclusion: Specific reference values of thyroid volume as a function of body surface area could be used for evaluating thyroid volume in clinical practice. The relation between body surface area and thyroid volume is coherent with what is known about the relation of thyroid volume to thyroid cancer risk, but the same is not true about the relation between thyroid volume and smoking habit.

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Thyroid ultrasound volume, structure and function after long-term high exposure of large population to polychlorinated biphenyls, pesticides and dioxin

Cited by 51 publications

References 48 publications

High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail

High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail

Relative effect potency estimates of dioxin-like activity for dioxins, furans, and dioxin-like PCBs in adults based on cytochrome P450 1A1 and 1B1 gene expression in blood

Thyroid Volume and Its Relation to Anthropometric Measures in a Healthy Cuban Population

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