1982
DOI: 10.1097/00000658-198211000-00001
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Thyroid Venous Catheterization in the Early Diagnosis of Familial Medullary Thyroid Carcinoma

Abstract: In kindreds with familial medullary thyroid carcinoma (MTC), individuals are often detected whose peripheral plasma calcitonin (CT) levels are undetectable in the basal state but increase minimally following provocative testing. The proper management of such patients has been uncertain, but most investigators have advocated repeat testing and evaluation after an interval of several months. The present study was conducted to evaluate the diagnostic implications of these modest increases in plasma calcitonin. In… Show more

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Cited by 29 publications
(9 citation statements)
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“…However, because MTC is derived from neuroendocrine cells, it is unresponsive to radioiodine and TSH suppression, and it is unclear as to which is the most appropriate treatment for patients with residual or recurrent disease after primary surgery and for those with distant metastasis. Until recently, management of metastatic disease has primarily been oriented toward the relief of symptoms (Wells et al 1982, Giraudet et al 2007), but in the last few years, much effort has been devoted to developing clinical trials using targeted therapies.…”
Section: Introductionmentioning
confidence: 99%
“…However, because MTC is derived from neuroendocrine cells, it is unresponsive to radioiodine and TSH suppression, and it is unclear as to which is the most appropriate treatment for patients with residual or recurrent disease after primary surgery and for those with distant metastasis. Until recently, management of metastatic disease has primarily been oriented toward the relief of symptoms (Wells et al 1982, Giraudet et al 2007), but in the last few years, much effort has been devoted to developing clinical trials using targeted therapies.…”
Section: Introductionmentioning
confidence: 99%
“…For local or regional recurrence in the neck and mediastinum, reoperation is the main treatment. However, cure is achieved only in 5-35% of the reoperated patients, and the remainder of patients are at high risk of developing distant metastasis (Wells et al 1982, Giraudet et al 2007. Distant metastases that are observed at presentation in 7-23% of unselected patients with MTC are the main cause of MTC-related death with survival rates of 25% at 5 years after their detection (Bergholm et al 1997, Modigliani et al 1998.…”
Section: Introductionmentioning
confidence: 99%
“…CT determination is a specific and sensitive tool in the management of patients with MTC. CT assay coupled with SVC is a precise method for localization of small foci of MTC (14)(15)(16)(17), especially when morphologic investigations are negative or doubtful. Norton et al were able to localize MTC tissue correctly by SVC with PG stimulation in every one of their 7 patients.…”
Section: Discussionmentioning
confidence: 99%