Thyrolipoma and thyrolipomatosis: 5 case reports and historical review of the literature

Ge, Yimin; Luna, Mario A.; Cowan, Daniel F.; Truong, Luan D.; Ayala, Alberto G.

doi:10.1016/j.anndiagpath.2009.08.003

Cited by 40 publications

(60 citation statements)

References 7 publications

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“…The mean age of these patients was 42 years (range: 11-76 years). The patients presented with either diffuse or nodular goiter with or without compression symptoms, similar to the presenting symptoms observed in our case (1). Three additional cases were later reported (8-10).…”

Section: Discussionsupporting

confidence: 56%

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Thyroid Lipomatosis

et al. 2012

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Thyroid lipomatosis is a rare condition characterized by the presence of abundant mature adipose tissue in the thyroid gland. We herein report the case of a 43-year-old man with chronic renal failure caused by amyloidosis presenting with an asymmetrically enlarging thyroid gland. The patient's thyroid hormone levels were normal, and test results for thyroid autoantibodies were negative. A thyroid scan showed diffuse uptake of the radioisotope with a cold area in the left lobe. The pathology of the thyroidectomy material indicated thyroid lipomatosis, and minimal amyloid staining was noted around the thyroid follicles. Thyroid lipomatosis should therefore be kept in mind when making a differential diagnosis of fatty infiltration of amyloid goiter.

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Section: Discussionsupporting

confidence: 56%

“…However, the presence of mature adipose tissue between the follicles in the central portion of the thyroid gland is extremely rare (1). We herein present a case of thyroid lipomatosis.…”

Section: Introductionmentioning

confidence: 93%

Thyroid Lipomatosis

et al. 2012

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“…Albeit extremely rare, diffuse mature adipose cell infiltration of the normal thyroid gland has been previously reported, referred to as thyrolipomatosis or diffuse lipomatosis of the thyroid gland (2). To the best of our knowledge, only 11 cases have been documented in the literature to date (2,(4)(5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 85%

“…To the best of our knowledge, only 11 cases have been documented in the literature to date (2,(4)(5)(6)(7)(8). We herein describe an additional case of thyrolipomatosis and review the fat-containing thyroid lesions.…”

Section: Introductionmentioning

confidence: 99%

“…Fat-containing thyroid lesions may be classified into two groups, namely neoplastic and non-neoplastic lesions. Thyrolipoma, also referred to as lipoadenoma, is the most common fat-containing lesion of the thyroid gland; it is considered to be a variant of follicular adenoma and is characterized by the presence of mature adipose cells interspersed throughout the follicular adenoma (2). Moreover, a few cases of papillary carcinoma and follicular carcinoma with adipose cells have been reported (1).…”

Section: Introductionmentioning

confidence: 99%

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Thyrolipomatosis: A case report with review of the literature

Ishida

Kashu²,

Morisaki³

et al. 2017

Molecular and Clinical Oncology

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Abstract. Fatty tissue is not usually present within the thyroid gland. Only a few fat-containing thyroid lesions have been reported to date, and thyrolipoma is the most common fat-containing lesion of the thyroid gland. Thyrolipomatosis is a condition characterized by diffuse mature adipose cell infiltration of the normal thyroid gland. In this report, we describe what is, to the best of our knowledge, the 12th documented case of thyrolipomatosis, and review the fat-containing lesions of the thyroid gland. A 68-year-old Japanese woman presented with a neck mass that had first been noticed ~7 years earlier.A computed tomography scan revealed diffuse thyroid gland enlargement and total thyroidectomy was performed. The histopathological examination revealed that mature fatty tissue was diffusely distributed throughout the thyroid gland, as well as among the hyperplastic follicles. Capsular formation or amyloid deposition were not observed. Nuclear grooves or intranuclear cytoplasmic inclusions were not observed. Accordingly, thyrolipomatosis was diagnosed. Albeit rare, various neoplastic and non-neoplastic thyroid lesions may contain mature fatty tissue. Therefore, thyrolipomatosis must be included in the differential diagnostic consideration of fat-containing lesions of the thyroid gland. IntroductionAlthough there is usually no mature fatty tissue within the thyroid gland, fat-containing thyroid lesions have been reported (1). Fat-containing thyroid lesions may be classified into two groups, namely neoplastic and non-neoplastic lesions. Thyrolipoma, also referred to as lipoadenoma, is the most common fat-containing lesion of the thyroid gland; it is considered to be a variant of follicular adenoma and is characterized by the presence of mature adipose cells interspersed throughout the follicular adenoma (2). Moreover, a few cases of papillary carcinoma and follicular carcinoma with adipose cells have been reported (1). Non-neoplastic fat-containing thyroid lesions include amyloid goiter and Hashimoto thyroiditis (1,3).Albeit extremely rare, diffuse mature adipose cell infiltration of the normal thyroid gland has been previously reported, referred to as thyrolipomatosis or diffuse lipomatosis of the thyroid gland (2). To the best of our knowledge, only 11 cases have been documented in the literature to date (2,4-8). We herein describe an additional case of thyrolipomatosis and review the fat-containing thyroid lesions. Case reportA 68-year-old Japanese woman with a past history of diabetes mellitus and angina pectoris presented at the Kusatsu General Hospital in August 2016 with a neck mass that had been noticed ~7 years earlier. A computed tomography scan revealed diffuse thyroid gland enlargement, compressing the trachea, with multiple calcifications in the bilateral lobes. The serum thyroid-stimulating hormone and free thyroxine (FT4) levels were within the normal range (0.63 µIU/ml, range 0.4-4.0 µIU/ml; and 1.01 ng/dl, range 0.8-1.7 ng/dl, respectively), but the free triiodothyronine (FT3) level was mildly d...

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Ultrasound‐guided fine‐needle aspiration biopsy of thyroid neoplasms with lipomatous stroma: Report of two cases

Toprak

Kashi

Hamele‐Bena

et al. 2021

Diagnostic Cytopathology

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Thyroid tumors with abundant adipose tissue component are rare, reportedly accounting for 0.98-2.8% of all thyroid nodules, and include entities such as thyroid lipoadenoma and thyroid carcinoma with lipomatous stroma (TCLS).They may be encountered on fine-needle aspiration biopsy (FNAB), which is widely used in evaluation of thyroid nodules. However, due to their relative rarity, adipose elements rarely are recognized preoperatively in these tumors. Herein, we report two cases of thyroid tumors with abundant adipose tissue, along with cytologic, histologic, and ultrasonographic features. Although an intermixture of adipose tissue and thyroid follicular cells is the key cytologic feature of thyroid tumors with adipose stroma, other cytologic findings, such as abundant fat droplets or isolated fragments of adipose tissue, also should raise the possibility of a fat-containing tumor, particularly when a biopsy is performed by a cytopathologist under ultrasonographic guidance and adequate radiologic-pathologic correlation.Cytopathologists should be aware that overlooking lesional adipose tissue within a thyroid neoplasm might give the false impression of a non-diagnostic or sparsely cellular FNAB specimen.

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Thyrolipoma and thyrolipomatosis: 5 case reports and historical review of the literature

Cited by 40 publications

References 7 publications

Thyroid Lipomatosis

Thyroid Lipomatosis

Thyrolipomatosis: A case report with review of the literature

Ultrasound‐guided fine‐needle aspiration biopsy of thyroid neoplasms with lipomatous stroma: Report of two cases

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