Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques

Yang, Chengzhe; Lü, Ming; Chen, Wenbin; He, Zhao; Hou, Xu; Feng, Mei; Zhang, Hongjia; Tao, Bo; Zhou, Xiaoming; Yu, Yong; Zhang, Haiqing; Zhao, Meng; Wang, Laicheng; Yu, Chunxiao; Gao, Ling; Jiang, Wenjian; Zhang, Qunye; Zhao, Jiajun

doi:10.1084/jem.20181473

Cited by 34 publications

(16 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition to dyslipidemia, inflammation is another mechanism of SCH leading to atherosclerosis. TSH could directly bind to TSH receptors in macrophages, thereby aggravating vascular inflammation and contributing to atherogenesis [ 39 ]. Another previous study showed that the serum TSH level was positively associated with circulating retinol-binding protein 4 (RBP4) [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Characteristics of coronary artery disease in patients with subclinical hypothyroidism: evaluation using coronary artery computed tomography angiography

Zhou

Shi

Wang

et al. 2021

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background Subclinical hypothyroidism (SCH) has recently been acknowledged as an independent risk factor for coronary artery disease (CAD). However, the characteristics of CAD in patients with SCH are not fully understood. This study aims to evaluate the features of CAD in patients with SCH using coronary computed tomographic angiography (CCTA). Materials and methods From 1 April, 2018 to 30 June, 2020, 234 consecutive SCH patients with coronary plaques identified on CCTA were included retrospectively. They were further subdivided into different degree of SCH groups (mild SCH vs. moderate SCH vs. severe SCH: 143 vs 62 vs 28) and different gender groups (men with SCH vs. women with SCH:116 vs 118). The distributions and types of plaques, luminal narrowing, segment involvement scores (SIS) and segment stenosis scores (SSS) were evaluated and compared among the different groups. Results Patients with severe SCH had fewer calcified plaques (0.7 ± 0.9 vs. 2.0 ± 1.9, p < 0.001) and more non-calcified plaques (0.9 ± 1.0 vs. 0.3 ± 0.5, p < 0.001) than those with mild SCH. As the SCH condition worsened, the proportion of non-calcified plaques significantly increased. Whereas there were no significant discrepancies in SIS and SSS among patients with different grades of SCH (all p > 0.05). Men with SCH had higher SIS (3.9 ± 2.3 vs. 3.0 ± 2.3, p = 0.004) and SSS (7.8 ± 5.4 vs. 5.4 ± 3.0, p = 0.002) than women. Multivariate logistic and linear regression analysis demonstrated that grades of SCH (Moderate SCH, odds ratio [OR] 2.11; 95% CI 1.03–4.34, p = 0.042; severe SCH, OR: 10.00; 95% CI 3.82–26.20, p < 0.001, taken mild SCH as a reference) was independently associated with the presence of non-calcified plaques, whereas sex (B: 1.67; 95% CI 0.27–3.10, p = 0.009) was independently associated with SSS. Conclusions Severe SCH is associated with non-calcified plaques, and men with SCH have higher total plaque burden than women. We suggest that it is important to evaluate for coronary plaque in SCH patients, especially those with severe SCH and men with SCH.

show abstract

Section: Discussionmentioning

confidence: 99%

Characteristics of coronary artery disease in patients with subclinical hypothyroidism: evaluation using coronary artery computed tomography angiography

Zhou

Shi

Wang

et al. 2021

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“…In addition to dyslipidemia, in ammation is another mechanism of SCH leading to atherosclerosis. TSH could directly bind to TSH receptors in macrophages, thereby aggravating vascular in ammation and contributing to atherogenesis [34]. Another previous study showed that the serum TSH level was positively associated with circulating retinol-binding protein 4 (RBP4) [35].…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Coronary Artery Disease in Patients with Subclinical Hypothyroidism: Evaluation Using Coronary Artery Computed Tomography Angiography

Zhou

Shi

Wang

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Subclinical hypothyroidism (SCH) has recently been acknowledged as an independent risk factor for coronary artery disease (CAD). However, the characteristics of CAD in patients with SCH are not fully understood. This study aims to evaluate the features of CAD in patients with SCH using coronary computed tomographic angiography (CCTA).Materials and Methods: From 1 April, 2018 to 30 June, 2020, 234 consecutive SCH patients with coronary plaques identified on CCTA were included retrospectively. They were further subdivided into different degree of SCH groups (mild SCH vs. moderate SCH vs. severe SCH: 143 vs 62 vs 28) and different gender groups (men with SCH vs. women with SCH:116 vs 118). The distributions and types of plaques, luminal narrowing, segment involvement scores (SIS) and segment stenosis scores (SSS) were evaluated and compared among the different groups.Results: Patients with severe SCH had fewer calcified plaques (0.7 ± 0.9 vs. 2.0 ± 1.9, p < 0.001) and more non-calcified plaques (0.9 ± 1.0 vs. 0.3 ± 0.5, p < 0.001) than those with mild SCH. As the SCH condition worsened, the proportion of non-calcified plaques significantly increased. Whereas there were no significant discrepancies in SIS and SSS among patients with different grades of SCH (all p > 0.05). Men with SCH had higher SIS (3.9 ± 2.3 vs. 3.0 ± 2.3, p = 0.004) and SSS (7.8 ± 5.4 vs. 5.4 ± 3.0, p = 0.002) than women. Multivariate logistic and linear regression analysis demonstrated that grades of SCH (Moderate SCH, odds ratio [OR]: 2.11; 95% CI 1.03–4.34, p = 0.042; severe SCH, OR: 10.00; 95% CI 3.82–26.20, p < 0.001, taken mild SCH as a reference) was independently associated with the presence of non-calcified plaques, whereas sex (B: 1.67; 95% CI 0.27–3.10, p = 0.009) was independently associated with SSS. Conclusions: Severe SCH is associated with non-calcified plaques, and men with SCH have higher total plaque burden than women. We suggest that it is important to evaluate for coronary plaque in SCH patients, especially those with severe SCH and men with SCH.

show abstract

“…Ablation of thyroid-stimulating hormone receptor inhibits the formation of atherosclerosis by reducing vascular inflammation and macrophage burden [190].…”

Section: Signaling Pathways Involved In Macrophage Polarizationmentioning

confidence: 99%

Macrophage origin, phenotypic diversity, and modulatory signaling pathways in the atherosclerotic plaque microenvironment

Liu¹,

Zhang²,

Sun³

et al. 2021

View full text Add to dashboard Cite

show abstract

Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques

Cited by 34 publications

References 60 publications

Characteristics of coronary artery disease in patients with subclinical hypothyroidism: evaluation using coronary artery computed tomography angiography

Characteristics of coronary artery disease in patients with subclinical hypothyroidism: evaluation using coronary artery computed tomography angiography

Characteristics of Coronary Artery Disease in Patients with Subclinical Hypothyroidism: Evaluation Using Coronary Artery Computed Tomography Angiography

Macrophage origin, phenotypic diversity, and modulatory signaling pathways in the atherosclerotic plaque microenvironment

Contact Info

Product

Resources

About