Thyrotropin-Induced Hyperthyroidism. A four years follow up study in a 10 year old girl with goiter

Krawczyńska, H; Wójcik, Kinga; Małunowicz, E; Chmura, M

doi:10.1203/00006450-198101000-00088

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1991

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“…As presented in part at the 19th and 26th Annual Meeting of ESPE in 1980 [12] and 1987 [13], we have treated this girl with the biologically less active dextro-isomer of thy roxine (DT4) in an attempt to suppress TSH secretion [14][15][16]. In the present paper we describe the favorable long-term effect of this treatment which led to a normal ization of the thyroid status and the disappearance of the goiter.…”

Section: Introductionmentioning

confidence: 99%

10 Years of Successful Treatment with Dextrothyroxine in a Girl with TSH-Induced Hyperthyroidism

Krawczyńska

Wójcik-Musiałek²,

Illig³

1991

Horm Res

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14 years ago, a 5.7-year-old healthy girl was treated with desiccated thyroid for a goiter and elevated TSH levels. The goiter disappeared and TSH levels were normalized. However, hyperthyroidism appeared. Without therapy, the goiter reappeared and hyperthyroidism aggravated. Based on hormone values, TSH-induced hyperthyroidism was diagnosed. After exclusion of neoplastic TSH secretion, treatment with dextrothyroxine (DT₄) was initiated at age of 10 years and continued during the last 10 years (except for short periods). The girl became euthyroid, has no goiter and normal TSH values. Since thyrotrophs and peripheral tissues are probably normally sensitive to T₄, we postulate that her hypothalamopituitary-thyroid control is operating on a higher set point level for T₄.

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Section: Introductionmentioning

confidence: 99%

10 Years of Successful Treatment with Dextrothyroxine in a Girl with TSH-Induced Hyperthyroidism

Krawczyńska

Wójcik-Musiałek²,

Illig³

1991

Horm Res

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Thyrotropin-Induced Hyperthyroidism. A four years follow up study in a 10 year old girl with goiter

Abstract: H.KRAwczY~KA K.W6JCWE.ULWOWICTY.CUW 71 Endocrine Unit and the 1.Depsrtaent of Ped i a t r i c a , C h i l d r e n c s Hospital i n

Cited by 1 publication

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10 Years of Successful Treatment with Dextrothyroxine in a Girl with TSH-Induced Hyperthyroidism

10 Years of Successful Treatment with Dextrothyroxine in a Girl with TSH-Induced Hyperthyroidism

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