Thyroxine and propylthiouracil effects in vivo on alpha and beta adrenergic receptors in rat heart

Ciaraldi, Theodore P.; Marinetti, G.V.

doi:10.1016/0006-291x(77)91615-1

Cited by 199 publications

(54 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…40 However, the data presented in this paper are difficult to evaluate in terms of specific labeling of a-receptors, since no experiments documenting appropriate kinetics, stereospecificity, or order of agonist competition were reported.…”

Section: Previous Attempts To Identify Myocardial A-receptors By Radimentioning

confidence: 94%

Alpha-adrenergic receptors in rat myocardium. Identification by binding of [3H]dihydroergocryptine.

Williams¹,

Lefkowitz²

1978

Circulation Research

View full text Add to dashboard Cite

Section: Previous Attempts To Identify Myocardial A-receptors By Radimentioning

confidence: 94%

Alpha-adrenergic receptors in rat myocardium. Identification by binding of [3H]dihydroergocryptine.

Williams¹,

Lefkowitz²

1978

Circulation Research

View full text Add to dashboard Cite

“…Thyroid hormones modulate cardiac activity and the number of adrenoceptors and muscarinic receptors in heart: in cardiac membranes from hypothyroid rats, there is a moderate decrease in 13-adrenoceptors [1,2], an increase in nmscarinic receptors [3], and a slight increase [4] or no change [1] in a-adrenoceptors, By contrast, hyperthyroidism is characterized by an increase in the number of/3-adrenoceptors (quantified by [3H] dihydroalprenolol) [ 1,5 ] whereas the number ofmuscarinic receptors [3] and c~-adrenoceptors [1,2,6] decreases.…”

Section: Introductionmentioning

confidence: 99%

Decreased secretin and glucagon responsiveness of adenylate cyclase in cardiac membranes from hypothyroid rats

et al. 1981

View full text Add to dashboard Cite

“…It has been reported that there are different numbers of 13-adrenoceptors changed in adipose tissue and heart muscle of hyper and hypothyroid rats (8,9,27). Moreover, Correze et al (1) and Armstrong et al (11,12) observed that the activity of cyclic AMP phosphodies terase of adipocytes increased in hypothyroid rats.…”

Section: Discussionmentioning

confidence: 99%

“…This phenomenon may be explained by changes in number and affinity of the receptors (8,9), the reduced activity of adenylate cyclase (10) and the increased activity of low Km cyclic AMP phos phodiesterase (1l, 12), all of which have been observed in hypothyroid rat tissues. In our laboratory, the effects of adrenergic agonists on hypothyroid rat tissues were investigated by using the isolated atria and liver (13)(14)(15).…”

mentioning

confidence: 99%

Effect of thyroid hormone on cyclic AMP phosphodiesterase in rat kidney.

Hagino¹,

Uematsu²,

Tachibana³

et al. 1980

Jpn.J.Pharmacol

View full text Add to dashboard Cite

Abstract-The effect of thyroid hormone on the activity of low Km cyclic AMP phos phodiesterase of the particulate fraction from the kidney was investigated.This enzyme activity increased in the cortex from hypothyroid rats and reverted to the normal level after the subcutaneous administration of L-3,5,3'-triiodothyronine (T3) daily for 3 days. However, this hormone did not affect the enzymes from the normal rats. In vitro experiments revealed that T3 as well as various known phosphodiesterase inhibitors similarly inhibited the activity of low Km cyclic AMP phosphodiesterase from both normal and hypothyroid rat kidneys. The results of the present study suggest that the effect of thyroid hormone on cyclic AMP phosphodiesterase was not direct but was mediated by a modulation of the rate of protein synthesis and an unknown mecha nism in the kidney.Cyclic AMP phosphodiesterase is the only known enzyme which metabolizes cyclic AMP to 5'-AMP. This enzyme is distributed ubiquitously in various tissues and species.Moreover, the activity of this enzyme is regulated by hormones such as insulin, glucagon and catecholamines (1-4).Hypothyroid rats lose the ability to respond to epinephrine (5-7). This phenomenon may be explained by changes in number and affinity of the receptors (8, 9), the reduced activity of adenylate cyclase (10) and the increased activity of low Km cyclic AMP phos phodiesterase (1l, 12), all of which have been observed in hypothyroid rat tissues. In our laboratory, the effects of adrenergic agonists on hypothyroid rat tissues were investigated by using the isolated atria and liver (13-15).We examined the relationship between cyclic AMP phosphodiesterase and thyroid status in the rat kidney and our findings are reported herein. MATERIALS AND METHODSMale Wistar rats were made hypothyroidic by feeding a 0.15% propylthiouracil diet for more than 12 weeks. Concentrations of L-3,5,3'-triiodothyronine (T3) and thyroxine in the serum markedly decreased in these rats, as described previously (16). Hypothyroid rats were given 50 ,€g of T3 per 100 g body weight s.c., daily x 3 and sacrificed 48 h after the last administration of T3. T3 concentration in the plasma was restored to normal or slightly higher values at this point of time.Preparation of cyclic AMP phosphodiesterase:The soluble and particulate fractions

show abstract

Thyroxine and propylthiouracil effects in vivo on alpha and beta adrenergic receptors in rat heart

Cited by 199 publications

References 25 publications

Alpha-adrenergic receptors in rat myocardium. Identification by binding of [3H]dihydroergocryptine.

Alpha-adrenergic receptors in rat myocardium. Identification by binding of [3H]dihydroergocryptine.

Decreased secretin and glucagon responsiveness of adenylate cyclase in cardiac membranes from hypothyroid rats

Effect of thyroid hormone on cyclic AMP phosphodiesterase in rat kidney.

Contact Info

Product

Resources

About