Thyroxine Prophylaxis after Bilateral Subtotal Thyroidectomy for Multinodular Goiter.

Kulaçoğlu, Hakan; Dener, Cenap; Zıraman, İpek; Kama, Nuri Aydın

doi:10.1507/endocrj.47.349

Cited by 7 publications

(7 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Transient increase in Thyroid stimulating hormone (TSH), with peak levels 3 to 6 months after the operation, has been detected after thyroidectomy (19) . In some patients early transient hypothyroidism is developed and subsides after some months.…”

Section: Discussionmentioning

confidence: 99%

Response of Bone Mineral Density to Physical Exercises after Thyroidectomy

Mohamady¹

2015

View full text Add to dashboard Cite

Introduction: Thyroidectomy could be associated with bone loss because of an endogenous excess of thyroxin, over enthusiastic thyroid replacement therapy following surgery, deregulation of bone resorption as consequence of calcitonin deficiency or some combination of these factors. The aim was to investigate the effect of weight bearing exercises on Improving bone mineral density in post thyroidectomy patients suffering from osteoporosis. Subjects and methods: Thirty osteoporotic patients were assigned randomly into two equal groups; their ages ranged from 20-45 years. The study group received weight bearing exercises program in addition to routine medical treatment. Control group received medical treatment only. Study group received two sessions per week for two successful months. The data were collected before and after the same period of treatment for both groups. Evaluation procedures were carried out to evaluate the bone mineral density using Dual Energy X-ray Absorptiometry. Results: Post treatment both groups showed a variant improvement in bone mineral density, but a significant improvement difference was recorded between the two groups in favor of the study group. Percentage of improvement of bone mineral density in the study group was 10.69%, while it was 2.8% in the control group. Conclusion: Weight bearing exercises were considered to be an effective modality for improving bone mineral density in subjects suffering from osteoporosis following thyroidectomy.

show abstract

Section: Discussionmentioning

confidence: 99%

Response of Bone Mineral Density to Physical Exercises after Thyroidectomy

Mohamady¹

2015

View full text Add to dashboard Cite

show abstract

“…The prevention of goitre recurrence is of great clinical concern, especially in iodine‐deficient areas (Gaitan et al ., 1991; Miccoli et al ., 1993; Feldkamp et al ., 1997; Kulacoglu et al ., 2000; Rotondi et al ., 2000). In cases of goitre recurrence, a second surgical intervention is often required, with increased risk of serious complications (Reeve et al ., 1988).…”

Section: Discussionmentioning

confidence: 99%

“…In iodine‐deficient areas L‐T4 therapy has been advocated as a useful tool to hinder the recurrence of nontoxic nodular goitre (Ibis et al ., 1991; Miccoli et al ., 1993; Kulacoglu et al ., 2000). Because of the high sensitivity to TSH of the iodine‐depleted thyroid gland (Bray, 1968; Brabant et al ., 1992), suppressive L‐T4 therapy is needed for the prevention of postintervention goitre recurrence (Ibis et al ., 1991; Miccoli et al ., 1993).…”

Section: Discussionmentioning

confidence: 99%

“…Many factors contribute to goitre recurrence and the prophylactic efficacy of postsurgery l ‐thyroxine (L‐T4) therapy is controversial (Gharib & Mazzaferri, 1998). Most studies from iodine‐sufficient areas deny the effectiveness of L‐T4 therapy (Persson et al ., 1982; Geerdsen & Frolund, 1984; Berghout et al ., 1989; Berglund et al ., 1990; Bistrup et al ., 1994), whereas other studies regarding endemic areas are fairly uniform in assessing the need for this treatment (Ibis et al ., 1991; Miccoli et al ., 1993; Kulacoglu et al ., 2000). Iodine supplementation has been compared with L‐T4 therapy in the prevention of goitre recurrence (Feldkamp et al ., 1997), without, however, taking into account that the effectiveness of L‐T4 varies according to both the extent of the surgical resection and the degree of TSH suppression (Rotondi et al ., 2000).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Iodized salt improves the effectiveness of l‐thyroxine therapy after surgery for nontoxic goitre: a prospective and randomized study

Carella¹,

Mazziotti²,

Rotondi³

et al. 2002

Clinical Endocrinology

View full text Add to dashboard Cite

Our short-term prospective and randomized study leads us to conclude that, in patients living in a moderate iodine-deficient area and undergoing thyroid surgery for nontoxic goitre: (1) the iodine prophylaxis improves the effects of postsurgery nonsuppressive L-T4 therapy on thyroid remnant size. (2) In patients treated with L-T4 alone the therapeutic effectiveness decreases in the presence of a large postsurgery thyroid remnant. With the addition of iodine, the L-T4 maintains a similar efficacy in patients with either a large or a small remnant. (3) During treatment with L-T4 alone the highest therapeutic effectiveness is attained by lowering the plasma TSH concentration. With the addition of iodized salt to the daily diet the effects of L-T4 on remnant size are relevant independently of the TSH levels.

show abstract

“…Seu emprego tem relação com a eficácia na diminuição dos nódulos de origem adenomatosa (Bartalena et al, 1991;Bennedbaek et al, 1999;Gharib e Mazzaferri, 1998;Gharib et al, 1987;Samuels, 2001;Wémeau et al, 2002). O uso deste tipo de terapia é defendido por vários autores, especialmente nos estudos com populações de áreas onde há carência de iodo (Miccoli et al, 1993;Kulacoglu et al, 2000;Niepomniscze et al, 2001;Basili et al, 2003).…”

Section: Revisão Anatomopatológica -Agregados Linfocitários E Folículunclassified

Função tireóidea após lobectomia total por bócio não tóxico

Junior¹,

de²

View full text Add to dashboard Cite

Descritores: 1.Bócio nodular/cirurgia 2.Tireoidectomia/métodos 3.Hipotireoidismo/diagnóstico 4.Tireoidite auto-imune/diagnóstico 5. Tireoidite auto-imune/imunologia 6. Tireoidite auto-imune/patologia APÊNDICE Lista de FigurasFigura 1 Grau 0 -Ausência de infiltrado ou folículos Figura 2 Grau I -até três agregados linfocitários Figura 3Grau II -Três a oito agregados Figura 4Grau III -mais de oito agregados Figura 5Grau IV -Hashimoto Figura 6Grau III -Intensa presença de folículos linfóides Figura 7Variação TSH pré-operatório e pós-operatório (n=186) diferença média estimada de 4,82, com intervalo de confiança de 95% de 3,09 a 6,54 (p<0,001). Figura 8Variação TSH pré-operatório e pós-operatório grupo eutireóideo (n=125) diferença média estimada de 1,69, com intervalo de confiança de 95% de 1,49 a 1,90 (p<0,001). Figura 9Distribuição dos casos segundo sexo (p=0,228). Figura 10Distribuição conforme a idade (p=0,200). Figura 11Indicação da operação (p=0,192). Figura 12Diagnóstico anatomopatológico (p=0,759). Figura 13Classificação semiquantitativa dos agregados linfóides. Figura 14Classificação semiquantitativa de folículos linfóides. Figura 15Valores de TSH pré-operatório entre os grupos estudados. Figura 16Relação do lobo tireóideo removido. Figura 17Distribuição dos volumes (cm 3 ) dos cotos remanescentes. Figura 18Relação do volume do lobo remanescente com os grupos. Figura 19Distribuição de anticorpos antitireoglobulina (AcTg). Figura 20Distribuição de anticorpos antiperoxidase (AcTPO). Figura 21Relação do lobo removido com o volume do coto remanescente (p=0,020). Figura 22Relação lobo removido, volume do coto remanescente e hipotireoidismo. Figura 23Relação de anticorpos antiperoxidase e a quantidade de agregados linfocitários. Figura 24Relação de anticorpos antiperoxidase e presença de folículos linfóides. Lista de TabelasTabela 1 Análise do tempo de seguimento em meses desde a data da operação até a última avaliação. Tabela 2Indicação da operação e diagnóstico anatomopatológico. Tabela 3Valores de Índice de Massa Corpórea. Tabela 4 Distribuição das variáveis com valor de p referente ao testeQui-quadrado de Pearson significante (p<0,05). Tabela 5Medidas descritivas com valor de p <0,05, significante para hipotireoidismo. Tabela 6Valores correspondentes ao TSH (mU/L) pós-operatório precoce, até 2 meses, TSH no momento do início da terapêutica com levotiroxina e tempo de seguimento e intervalo livre de doença, em meses, para os casos com hipotireoidismo diagnosticado após 2 meses. Tabela 7Estudo comparativo entre agregados linfocitários e folículos linfóides. Lista de Abreviaturas

show abstract

Thyroxine Prophylaxis after Bilateral Subtotal Thyroidectomy for Multinodular Goiter.

Cited by 7 publications

References 4 publications

Response of Bone Mineral Density to Physical Exercises after Thyroidectomy

Response of Bone Mineral Density to Physical Exercises after Thyroidectomy

Iodized salt improves the effectiveness of l‐thyroxine therapy after surgery for nontoxic goitre: a prospective and randomized study

Função tireóidea após lobectomia total por bócio não tóxico

Contact Info

Product

Resources

About