THz spectroscopy with ultrahigh sensitivity

Brucherseifer, M.; Pellemans, H.P.M.; Bolívar, P. Haring; Kurz, H.

doi:10.1109/cleo.2000.907380

Cited by 3 publications

(2 citation statements)

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“…The problem of detecting the small signal from absorption, reflection and delay in a thin film can be solved by using what has been called differential THz timedomain spectroscopy [51] or ultra-high sensitivity spectroscopy [52]. DTDS measures a signal that comes purely from the difference caused by a thin film deposited on half of a sample holder; the other half is used as a reference.…”

Section: Proposed Solution: Double Modulated Dtdsmentioning

confidence: 99%

Noise Reduction in Terahertz Thin Film Measurements Using a Double Modulated Differential Technique

et al. 2002

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Differential terahertz (THz) time-domain spectroscopy (TDS) is a technique for decreasing noise levels in THz thin film characterization experiments. Characterizing thin films in the GHz to THz range is critical for the development of fast integrated circuits and photonic systems, and is potentially applicable to biosensors and proteomics. This paper shows how the differential technique, combined with double modulation, enables the study of thin films with noise reduction over normal TDS that improves at the film gets thinner. Double modulated differential THz-TDS has enabled the characterization of films with less than 1-μm thickness.

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Section: Proposed Solution: Double Modulated Dtdsmentioning

confidence: 99%

Noise Reduction in Terahertz Thin Film Measurements Using a Double Modulated Differential Technique

et al. 2002

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“…In this case, a pure avidin film acts as a reference to a film of biotin bound to avidin (figure 1). Double-modulated DTDS has been used for characterizing micron-thick films and is described elsewhere in detail (Jiang et al 2000, Brucherseifer et al 2000, Mickan et al 2002a. Figure 2 shows a schematic of a double-modulated DTDS spectrometer.…”

Section: Differential Thz-tds (Dtds)mentioning

confidence: 99%

Label-free bioaffinity detection using terahertz technology

et al. 2002

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We report the first use of differential terahertz time-domain spectroscopy for bioaffinity sensing. Binding is observed by measuring the transmission of a thin layer of biotin bound to the sensor protein avidin. We demonstrate the THz wave transmission of a sub-micron-thick film and sensitivity to 0.1 µg cm −2 of biotin. These results point the way for a host of biosensor applications using T-rays, or pulsed far-infrared (FIR) radiation.

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