Ti3C2Tx-reduced graphene oxide nanocomposite-based electrochemical sensor for serotonin in human biofluids

Su, Mengjie; Lan, Haitian; Tian, Lei; Jiang, Mengyuan; Cao, Xiaoqing; Zhu, Cailing; Yu, Chunmei

doi:10.1016/j.snb.2022.132019

Cited by 32 publications

(21 citation statements)

References 33 publications

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“…Ni NPs-RGO NC has the potential to be used in sensors and catalysis because of its distinctive features [ 124 ]. ST in human biofluids can currently be detected using a new EC sensor based on Ti 3 C 2 T x -RGO/GCE see Figure 4 B [ 125 ]. Hydrazine reduction and self-assembly were used to create the Ti 3 C 2 T x -RGO nanocomposite, which was then studied using SEM, TEM, XRD, and Raman spectroscopy.…”

Section: Gr-based Ec Sensors For Bioanalytes Detectionmentioning

confidence: 99%

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The Roadmap of Graphene-Based Sensors: Electrochemical Methods for Bioanalytical Applications

et al. 2022

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Graphene (GR) has engrossed immense research attention as an emerging carbon material owing to its enthralling electrochemical (EC) and physical properties. Herein, we debate the role of GR-based nanomaterials (NMs) in refining EC sensing performance toward bioanalytes detection. Following the introduction, we briefly discuss the GR fabrication, properties, application as electrode materials, the principle of EC sensing system, and the importance of bioanalytes detection in early disease diagnosis. Along with the brief description of GR-derivatives, simulation, and doping, classification of GR-based EC sensors such as cancer biomarkers, neurotransmitters, DNA sensors, immunosensors, and various other bioanalytes detection is provided. The working mechanism of topical GR-based EC sensors, advantages, and real-time analysis of these along with details of analytical merit of figures for EC sensors are discussed. Last, we have concluded the review by providing some suggestions to overcome the existing downsides of GR-based sensors and future outlook. The advancement of electrochemistry, nanotechnology, and point-of-care (POC) devices could offer the next generation of precise, sensitive, and reliable EC sensors.

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Section: Gr-based Ec Sensors For Bioanalytes Detectionmentioning

confidence: 99%

“…( B ) Synthesis of Ti 3 C 2 T x -RGO NC and its EC response for ST detection using GCE. Reprinted with permission from [ 125 ]. ( C ) Schematic of ACC-RGO@Cu(BTC)@α-MnO 2 based flexible electrode prepared by anodic-induced electrodeposition and EC detection of Ach from biological matrices.…”

Section: Figures Scheme and Tablesmentioning

confidence: 99%

The Roadmap of Graphene-Based Sensors: Electrochemical Methods for Bioanalytical Applications

et al. 2022

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“…8 The concentration range of SER is about 101− 283 ng mL −1 in human blood, 0.57−2 μM in serum, nearly 0.295−0.687 μM in urine, and about 0.8−3.7 nmol L −1 in cerebrospinal fluid. 9 An increase or decrease in SER will lead to psychological and physical health problems. 10 Some of them include chronic psychological disorder, migraine, sudden infant death syndrome, depression, and Alzheimer's and Parkinson's disease due to the low level of SER produced in the body.…”

Section: ■ Introductionmentioning

confidence: 99%

“…The reflection of the activities of the sympathoadrenal system is more likely associated with the level of SER in body fluids . The concentration range of SER is about 101–283 ng mL –1 in human blood, 0.57–2 μM in serum, nearly 0.295–0.687 μM in urine, and about 0.8–3.7 nmol L –1 in cerebrospinal fluid . An increase or decrease in SER will lead to psychological and physical health problems .…”

Section: Introductionmentioning

confidence: 99%

Zinc Phosphate-Incorporated Niobium Carbide as an Effective Electrocatalyst for Ultrasensitive and Selective Monitoring of Monoamine Neurotransmitter

Santhan

Hwa

2023

ACS Sustainable Chem. Eng.

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The earth-abundant, cost-effective, easier preparation of zinc phosphate eases its diverse implications in recent applications. We have synthesized two-dimensional niobium carbide (NbC)-encapsulated zinc phosphate Zn2P2O7. The physicochemical characteristics were determined, which demonstrate pure crystallinity and good integration of the composite samples. To improve and develop a sustainable environment, the Zn2P2O7/NbC composite will be an efficient material. The detection of pharmaceutical compounds is highly preferable in clinical approaches. The importance of serotonin (SER) has empowered sensor development with the fabricated Zn2P2O7-based electrode. The synergistic action prevailing in the composite material endowed the active sites with improved electrocatalytic activity. The increased addition of SER was acquired with two linear ranges from 0.019 to 563.68 μM. The lower detection limit was obtained as 0.0055 μM toward the exposed SER addition at a lower concentration, and the sensitivity was about 7.72 μA μM–1 cm–2. Analyses of other parameters such as repeatability, reproducibility, and stability indicate the excellent performance of the electrode. The presence of SER in human urine and blood serum samples can be identified very easily, and hence, analysis of real samples was performed. The as-obtained recovery results stated the excellent performance of the fabricated sensor.

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“…Serotonin, which is a monoamine neurotransmitter, plays a significant role in biological, physical, and psychological processes, such as appetite control, sleep pattern, sexual activity, and aggression [ 1 , 2 ]. The amount of serotonin in the human body should be controlled, and the normal range of serotonin in serum lies between 0.57 and 2.0 µM, whereas its normal amount in urine is considered in the range of 0.295–0.687 µM [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Design and Fabrication of α-MnO2-Nanorods-Modified Glassy-Carbon-Electrode-Based Serotonin Sensor

Khan

Alsalme

et al. 2022

Biosensors

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Serotonin is a very important monoamine neurotransmitter, which takes part in biological and psychological processes. In the present scenario, design and fabrication of a serotonin electrochemical sensor is of great significance. In this study, we have synthesized α-MnO2 via a hydrothermal synthesis method using potassium permanganate as a precursor. The physiochemical properties, such as structural and phase-purity of the prepared α-MnO2, were investigated by various characterization techniques and methods (powder X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy). Furthermore, the serotonin sensor was fabricated using α-MnO2 as an electrode modifier or electro-catalyst. The bare glassy carbon electrode (GCE) was adopted as a working substrate, and its active carbon surface was modified with the synthesized α-MnO2. This modified GCE (α-MnO2/GCE = MGCE) was explored as a serotonin sensor. The electrochemical investigations showed that the MGCE has excellent electro-catalytic properties towards determination of serotonin. The MGCE exhibits an excellent detection limit (DL) of 0.14 µM, along with good sensitivity of 2.41 µAµM−1 cm−2. The MGCE also demonstrated excellent selectivity for determination of serotonin in the presence of various electro-active/interfering molecules. The MGCE also exhibits good cyclic repeatability, stability, and storage stability.

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Ti3C2Tx-reduced graphene oxide nanocomposite-based electrochemical sensor for serotonin in human biofluids

Cited by 32 publications

References 33 publications

The Roadmap of Graphene-Based Sensors: Electrochemical Methods for Bioanalytical Applications

The Roadmap of Graphene-Based Sensors: Electrochemical Methods for Bioanalytical Applications

Zinc Phosphate-Incorporated Niobium Carbide as an Effective Electrocatalyst for Ultrasensitive and Selective Monitoring of Monoamine Neurotransmitter

Design and Fabrication of α-MnO2-Nanorods-Modified Glassy-Carbon-Electrode-Based Serotonin Sensor

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