Tibetan highland barley fiber improves obesity and regulates gut microbiota in high-fat diet-fed mice

Gan, Linyao; Han, Jing; Li, Chenyao; Tang, Jing; Wang, Xuebing; Ma, Yue; Chen, Yefu; Xiao, Dongguang; Guo, Xuewu

doi:10.1016/j.fbio.2023.102620

Cited by 17 publications

(1 citation statement)

References 37 publications

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“…Mucispirillum, a pathogen present throughout the GI tract, induces intestinal dysplasia, but the increase in its abundance due to HFD was reversed by AVN B [47] . Previous studies have also reported that HFD promotes the growth of harmful bacteria and fungi such as unclassified_f__Lachnospiraceae, Helicobacter, Lachnospiraceae_NK4A136_group, Enterorhabdus and Eurotium [48] .…”

Section: Discussionmentioning

confidence: 94%

Oat avenanthramide B alleviates high-fat diet-induced obesity via regulating fatty acid metabolism involved in gut bacteria and fungi remodeling

Liu,

Huang,

Guan

et al. 2024

Food Science and Human Wellness

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Section: Discussionmentioning

confidence: 94%

Oat avenanthramide B alleviates high-fat diet-induced obesity via regulating fatty acid metabolism involved in gut bacteria and fungi remodeling

Liu,

Huang,

Guan

et al. 2024

Food Science and Human Wellness

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Quinoa Peptides Alleviate Obesity in Mice Induced by a High‐Fat Diet via Regulating of the PPAR‐α/γ Signaling Pathway and Gut Microbiota

Li,

Feng,

et al. 2023

Molecular Nutrition Food Res

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ScopeThe obesity epidemic continues to be a major global public health threat with limited effective treatments. Peptides are a group of promising bioactive molecules. Both in vivo and in vitro studies have demonstrated that quinoa has potential prebiotic benefits. Thus, the present study aims to investigate the influence of quinoa peptides (QP) consumption on obesity and its underlying mechanisms in high‐fat diet (HFD)‐induced mice.Methods and resultsQP (1000 mg kg−1 day−1) is administered to HFD mice for 8 weeks, and is found to significantly reduce the body weight, and plasma levels of triacylglycerol (TG) and total cholesterol (TC) compare to the HFD group. In addition, QP significantly decreases lipid accumulation in the liver caused by HFD. The liver transcriptome analysis shows that the alleviation of QP on obesity is related to the PPAR signaling pathway. QP upregulates the expressions of PPAR‐α and its related genes and downregulates the expressions of PPAR‐γ and its downstream genes. Furthermore, QP remodels the community composition of gut microbiota by lowering the ratio of Firmicutes c Bacteroidetes (F/B).ConclusionThese findings suggest that QP consumption alleviates HFD‐induced obesity by regulating the PPAR‐α/γ signaling pathway in the liver and community structure of gut microbiota.

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In vitro conversion of ellagic acid to urolithin A by different gut microbiota of urolithin metabotype A

He,

Bian,

Zhao

et al. 2024

Appl Microbiol Biotechnol

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The metabolite urolithin A, a metabolite of the dietary polyphenol ellagic acid (EA), has significant health benefits for humans. However, studies on the gut microbiota involved in ellagic acid metabolism are limited. In this study, we conducted in vitro fermentation of EA using human intestinal microbiome combined with antibiotics (vancomycin, polymyxin B sulfate, and amphotericin B). Liquid chromatography-mass spectrometry (LC–MS/MS) analysis demonstrated that the production capacity of urolithin A by gut microbiota co-treated with polymyxin B sulfate and amphotericin B (22.39 µM) was similar to that of untreated gut microbiota (24.26 µM). Macrogenomics (high-throughput sequencing) was used to analyze the composition and structure of the gut microbiota. The results showed that the abundance of Bifidobacterium longum, Bifidobacterium adolescentis, and Bifidobacterium bifidum in the gut microbiota without antibiotic treatment or co-treated with polymyxin B sulfate and amphotericin B during EA fermentation was higher than that in other antibiotic treatment gut microbiota. Therefore, B. longum, B. adolescentis, and B. bifidum may be new genera involved in the conversion of EA to urolithin A. In conclusion, the study revealed unique interactions between polyphenols and gut microbiota, deepening our understanding of the relationship between phenolic compounds like EA and the gut microbiota. These findings may contribute to the development of gut bacteria as potential probiotics for further development. Key points • Intestinal microbiome involved in ellagic acid metabolism. • Gram-positive bacteria in the intestinal microbiome are crucial for ellagic acid metabolism. • Bifidobacterium longum, Bifidobacterium adolescentis, and Bifidobacterium bifidum participate in ellagic acid metabolism.

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Tibetan highland barley fiber improves obesity and regulates gut microbiota in high-fat diet-fed mice

Cited by 17 publications

References 37 publications

Oat avenanthramide B alleviates high-fat diet-induced obesity via regulating fatty acid metabolism involved in gut bacteria and fungi remodeling

Oat avenanthramide B alleviates high-fat diet-induced obesity via regulating fatty acid metabolism involved in gut bacteria and fungi remodeling

Quinoa Peptides Alleviate Obesity in Mice Induced by a High‐Fat Diet via Regulating of the PPAR‐α/γ Signaling Pathway and Gut Microbiota

In vitro conversion of ellagic acid to urolithin A by different gut microbiota of urolithin metabotype A

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