Ticarcillin and piperacillin adsorption on to polyethersulfone haemodiafilter membranes in an ex-vivo circuit

Economou, Caleb J.P.; Ordoñez, Jennifer; Wallis, Steven C.; Richards, Brent; McWhinney, Brett; Lipman, Jeffrey; Roberts, Jason A.

doi:10.1016/j.ijantimicag.2020.106058

Cited by 5 publications

(6 citation statements)

References 7 publications

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“…Further studies are needed to demonstrate the direct evidence of VCM adsorption onto the hemofilter membrane. Third, the amount of adsorption and/or the adsorption rate of the drug onto the hemofilter membrane in the in vitro circuit model may vary according to the initial concentration of the drug and amount of drug added to the circuit 11,20,29 . We conducted the experiments at a single initial concentration of VCM that could occur in vivo, but we did not consider the effects of varying initial drug concentrations or additions.…”

Section: Discussionmentioning

confidence: 99%

“…However, antibiotics can be also removed by adsorption onto a hemofilter membrane. This adsorption may depend on factors such as the material and structure of the membrane, ionic interactions between the drug and the hemofilter membrane, and binding to the plasma proteins of the drug 8–11 . If the contribution of adsorption to CL CHDF is relatively large, then it is expected that the aforementioned calculations for estimating CL CHDF are not applicable.…”

Section: Introductionmentioning

confidence: 99%

“…This adsorption may depend on factors such as the material and structure of the membrane, ionic interactions between the drug and the hemofilter membrane, and binding to the plasma proteins of the drug. [8][9][10][11] If the contribution of adsorption to CL CHDF is relatively large, then it is expected that the aforementioned calculations for estimating CL CHDF are not applicable. It has been reported that hemofiltration clearance of certain proteins due to adsorption could exceed the theoretical amounts due to hemofiltration.…”

Section: Introductionmentioning

confidence: 99%

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Contribution of diafiltration and adsorption to vancomycin clearance in a continuous hemodiafiltration circuit model in vitro

et al. 2022

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Background: Vancomycin (VCM) is eliminated mainly by diafiltration under continuous hemodiafiltration (CHDF), but the contribution of adsorption to CHDF clearance (CL CHDF ) of VCM using a polyacrylonitrile and sodium methallyl sulfonate copolymer membrane coated with polyethylenimine (AN69ST) or a polymethylmethacrylate (PMMA) membrane is unknown. This study sought to investigate the contribution of diafiltration and adsorption to the CL CHDF of VCM using AN69ST and PMMA membranes in vitro.Methods: An in vitro CHDF circuit model was developed. The initial concentration of VCM was 50 μg/mL and human serum albumin (HSA) was prepared at a concentration of 0, 2.5, or 5.0 g/dL. The effluent flow rate (Qe) was set at 800, 1500, or 3000 mL/h. The CL CHDF , diafiltration rate, and adsorption rate of VCM were calculated.Results: Total CL CHDF of VCM using the AN69ST membrane increased and decreased with increasing Qe and HSA concentration, respectively. Diafiltration and adsorption rates were 82.1 ± 9.8% and 12.1 ± 6.1% under all conditions, respectively. Total CL CHDF using the PMMA membrane increased with increasing Qe. Diafiltration and adsorption rates were 89.2 ± 20.4% and 4.6 ± 17.0% under all conditions, respectively. The observed CL CHDF values significantly correlated with the predicted CL CHDF , calculated according to a previous study as the product of Qe and the plasma unbound fraction.Conclusions: Diafiltration predominantly contributed to CL CHDF of VCM using AN69ST and PMMA membranes. When diafiltration rather than adsorption mainly contributes to the CL CHDF of VCM, the CL CHDF could be predicted from the Qe and HSA concentration, at least in vitro.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Contribution of diafiltration and adsorption to vancomycin clearance in a continuous hemodiafiltration circuit model in vitro

et al. 2022

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“…This phenomenon depends on many factors such as electric charge of the filter membrane, membrane material as well as its structure, an electric charge of a drug molecule and the degree of plasma protein binding. The filter membrane charge is most likely to play a large role in the level of drug adsorption, as was demonstrated by recent papers by Wan et al and Economou et al Both groups used similar experimental design, but the first group used PAN membranes and observed that 46–48% of ticarcillin was adsorbed within 20 min of administration, while the second group using PES membranes observed a maximum level of ticarcillin adsorption not exceeding 15% [ 18 , 19 ]. In a study by Economou et al the level of piperacillin adsorption depended mostly the concentration of the drug in the experimental circuit and was irrespective of the blood flow rates used [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…The filter membrane charge is most likely to play a large role in the level of drug adsorption, as was demonstrated by recent papers by Wan et al and Economou et al Both groups used similar experimental design, but the first group used PAN membranes and observed that 46–48% of ticarcillin was adsorbed within 20 min of administration, while the second group using PES membranes observed a maximum level of ticarcillin adsorption not exceeding 15% [ 18 , 19 ]. In a study by Economou et al the level of piperacillin adsorption depended mostly the concentration of the drug in the experimental circuit and was irrespective of the blood flow rates used [ 19 ]. In the studies by Shiraishi et al an addition of albumins to the solution reduced the adsorption of teicoplanin on the filters of CRRT circuit despite significant interactions between albumin and filter membrane.…”

Section: Discussionmentioning

confidence: 99%

Adsorption of vancomycin, gentamycin, ciprofloxacin and tygecycline on the filters in continuous renal replacement therapy circuits: in full blood in vitro study

et al. 2020

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The aim of this study was to assess the in vitro adsorption of antibiotics: vancomycin, gentamicin, ciprofloxacin and tigecycline on both polyethyleneimine-treated polyacrylonitrile membrane of AN69ST filter and polysulfone membrane of AV1000 filter using porcine blood as a model close to in vivo conditions. The porcine blood with antibiotic dissolved in it was pumped into hemofiltration circuit (with AN69ST or AV1000 filter), ultrafiltration fluid was continuously returned to the reservoir containing blood with antibiotic. Blood samples to determine antibiotic concentrations were taken at minutes 0, 5, 15, 30, 45, 60, 90 and 120 from the pre- blood pump of the hemofiltration circuit. To assess possible spontaneous degradation of the drug in the solution there was an additional reservoir prepared for each antibiotic, containing blood with the drug, which was not connected to the circuit. In the case of vancomycin, ciprofloxacine and tigecycline, a statistically significant decrease in the drug concentration in the hemofiltration circuit in comparison to initial value as well as to the concentrations in the control blood was observed, both for polyacrylonitrile and plolysulfone membrane. In the case of gentamicin, significant adsorption was noted only on polyacrylonitrile membrane. Our studies demonstrated that in full blood adsorption of antibiotics may be big enough to be of clinical significance. In particular in the case of polyacrylonitrile membrane.

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Drug dosing optimization in critically ill children under continuous renal replacement therapy: from basic concepts to the bedside model informed precision dosing

Oualha,

Thy,

Bouazza

et al. 2024

Expert Opinion on Drug Metabolism & Toxicology

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Ticarcillin and piperacillin adsorption on to polyethersulfone haemodiafilter membranes in an ex-vivo circuit

Cited by 5 publications

References 7 publications

Contribution of diafiltration and adsorption to vancomycin clearance in a continuous hemodiafiltration circuit model in vitro

Contribution of diafiltration and adsorption to vancomycin clearance in a continuous hemodiafiltration circuit model in vitro

Adsorption of vancomycin, gentamycin, ciprofloxacin and tygecycline on the filters in continuous renal replacement therapy circuits: in full blood in vitro study

Drug dosing optimization in critically ill children under continuous renal replacement therapy: from basic concepts to the bedside model informed precision dosing

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