Ticarcillin plus clavulanic acid versus moxalactam in the treatment of skin and soft tissue infections

Assessment of Antibiotic Treatment of Cellulitis and Erysipelas

“…The use of a cephalosporin rather than a penicillin was not supported despite trials that showed equivalence. [23][24][25]54 Similarly, glycopeptide, 37,38 oxazolidinone, 44 and daptomycin 41 did not show superiority to the other antibiotics. The use of combination therapy was not supported, as the trials with combination therapy did not demonstrate better outcomes.…”

“…One study 54 (n = 18) compared ticarcillin and clavulanic acid with moxalactam. No difference between the groups was found (RR = 1.00; 95% CI, 0.82-1.22) (eFigure 9.5 in the Supplement).…”

“…A number of studies did not adequately explain the process of allocation concealment or blinding (Figure 2), and only more recent studies provided sample size calculations. Eleven studies 15,19,24,[29][30][31]40,44,54,58 were described as open, with 5 additional studies presumed to be not blinded (their design was not specified). 25,27,28,50,56 This lack of blinding, in combination with a lack of objective outcome measures, could increase the risk of bias.…”

Ampicillin‐Sulbactam and Ticarcillin‐Clavulanic Acid: A Comparison of Their In Vitro Activity and Review of Their Clinical Efficacy

“…In the comparative studies, no major differences were noted with respect to the types of infections treated, and concomitant medical problems including diabetes.! ": 116,118 hypertenston.!" and drug depencency.!"…”

“…although statistical comparisons generally were not provided."? 116,118 The duration of parenteral therapy with each combination ranged from 4-18 days; wound care, debridement, incision, and drainage of the infected site were performed as necessary.l": 118,119 Culture of the infected sites frequently revealed Streptococcus sp, S. aureus, anaerobic cocci, P. mirabilis, Klebsiella sp, and other Enterobacteriaceae.…”