Tick-Borne Encephalitis sequelae at long-term follow-up: a self-reported case-control study

Abstract

At the long-term follow-up, the patients scored significantly lower in a diversity of neurocognitive and motor symptoms, in comparison with controls. These sequelae and their pathogenesis should be further explored and specific neurocognitive assessment tests are needed.

Mental fatigue and impaired cognitive function after an acquired brain injury

“…Mental fatigue is a common symptom following traumatic brain injury (TBI) (Cantor, Gordon, & Gumber, 2013), stroke (Staub & Bogousslavsky, 2001), meningitis or encephalitis (Veje et al., 2016), and neurological diseases (Penner & Paul, 2017). In the case of long‐lasting mental fatigue, even once a person has recovered, they still may have difficulty returning to work and pursuing social activities.…”

Estimating costs and health outcomes of publicly funded tick-born encephalitis vaccination: A cost-effectiveness analysis

“…Neurological sequelae is reported in 30-40% of cases, ranging from concentration disabilities to tremor and paresis. [1,[6][7][8][9][10][11][12] In Europe two inactivated vaccines are presently registered, FSME-immune (available in Sweden since 1980s, Pfizer) and Encepur (GSK). The immunogenicity of any of those vaccines is 95-100%.…”

“…The probabilities of events after the incidence year were derived from several follow-up studies on TBE-infection. [1,[6][7][8][9][10][11][12]…”

“…The probabilities of dying due to TBE in the incidence year were derived from clinical follow up studies on TBE. [1,[6][7][8][9][10][11][12] There is no available data regarding the increased risk of death from TBE after the incidence year and therefore it was assumed that these probabilities are the same as for the incident year. As patients with severe sequelae have a higher risk of dying from other causes like infections and respiratory insufficiency this appears to be a plausible assumption.…”

Vaccinations for Neuroinfectious Disease: A Global Health Priority

“…Of the three known subtypes, the Siberian and Far-Eastern subtypes are associated with comparatively more severe disease than the European subtype [13]. Clinical manifestations range from fever, headache and nausea to encephalitis with or without altered consciousness [14]. One study of the Polish health registry reported that TBE presents as meningitis in about 50 % patients, meningoencephalitis in about 40 % and meningoencephalomyelitis in about 10 % [13].…”