Tickborne Encephalitis Vaccines

Hombach, Joachim; Barrett, Alan D.T.; Kollaritsch, Herwig

doi:10.1016/b978-0-323-35761-6.00059-6

Cited by 11 publications

(14 citation statements)

References 137 publications

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“…Transmission of TBE usually occurs between March and November (temperature >8°C) at altitudes below 2100 m in the habitat of small rodents who are the main hosts and reservoirs for the virus [6,7]. Thus, the main risk areas are forested and agricultural lands, but also gardens of private homes and occasionally public parks in cities.…”

Section: Epidemiologymentioning

confidence: 99%

“…This includes maintenance of water and electrolyte balance, sufficient caloric intake, and medication to suppress pain, seizures, agitation, and fever. Physio-and ergotherapy are usually indicated [6]. Neurosurgical interventions are indicated on rare occasions.…”

Section: Diagnostics and Treatmentmentioning

confidence: 99%

“…In Europe, two inactivated vaccines are marketed, both in an adult and in a half-dose pediatric formulation (additional vaccines in Russia [2,6,14]). The route of application is intramuscular injection (in exceptional cases, subcutaneously):…”

Section: Vaccinationmentioning

confidence: 99%

“…Some studies initiated by the respective vaccine producers suggested that their product was superior to that of their competitor. However, as neither reviewers, nor the World Health Organization position paper, nor the authors in the TBE chapter the latest edition of the Plotkin textbook expressed a preference for either of the two vaccines, there is apparently general agreement that both are very similarly effective and well tolerated [6,14]. There is limited clinical and more research evidence that both vaccines induce protective immunity not only against the homologous European TBE virus subtype, but also against the Siberian and Far Eastern strains [14,21].…”

Section: Vaccinationmentioning

confidence: 99%

“…It is the only country with official universal TBE vaccination recommendation. The immunization coverage of 85% (2011) and 82% (2013), respectively, has resulted in an overall reduction of TBE to 16% as compared to the pre-vaccination era [6,23,24]. In children aged 0-14 years, field effectiveness rates for the vaccine of 94.0% (95% confidence interval, 88.0-97.0) and 88.6% (95% confidence interval, 63.3-96.5), respectively, have been recorded.…”

Section: Vaccinationmentioning

confidence: 99%

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Tick-borne Encephalitis—Need to know for Professionals outside Endemic Areas

Steffen¹

2019

DSAHMJ

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Tick-borne Encephalitis (TBE) is an arboviral infection widespread in Europe and northern parts of Asia. Ticks transmit the associated flavivirus usually between March and November to people with outdoor activities in the countryside, in gardens or, rarely, in urban parks. The clinical picture of TBE has two phases: after an uncharacteristic febrile illness and a brief interval in which neurological symptoms occur in a minority of the infected patients. In children, meningitis is the predominant syndrome, whereas the proportion of patients with more severe encephalitis and encephalomyelitis increases with growing age. Consequently, children may suffer from cognitive defects and adults from neurological defects after the acute phase. As there is no therapy for TBE, prevention is of paramount importance. The first line of defense is to avoid tick "bites" (actually stings). Various effective and well-tolerated vaccines are marketed in Europe, all parts of Russia, and in China.

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Section: Epidemiologymentioning

confidence: 99%

Section: Diagnostics and Treatmentmentioning

confidence: 99%

Section: Vaccinationmentioning

confidence: 99%

Section: Vaccinationmentioning

confidence: 99%

Section: Vaccinationmentioning

confidence: 99%

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Tick-borne Encephalitis—Need to know for Professionals outside Endemic Areas

Steffen¹

2019

DSAHMJ

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Can the booster interval for the tick-borne encephalitis (TBE) vaccine ‘FSME-IMMUN’ be prolonged? — A systematic review

Steffen

Erber

2021

Ticks and Tick-borne Diseases

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Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination

et al. 2019

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Flaviviruses have an increasing global impact as arthropod-transmitted human pathogens, exemplified by Zika, dengue, yellow fever (YF), West Nile, Japanese encephalitis, and tick-borne encephalitis (TBE) viruses. Since all flaviviruses are antigenically related, they are prone to phenomena of immunological memory (‘original antigenic sin’), which can modulate immune responses in the course of sequential infections and/or vaccinations. In our study, we analyzed the influence of pre-existing YF vaccine-derived immunity on the antibody response to TBE vaccination. By comparing samples from YF pre-vaccinated and flavivirus–naive individuals, we show that YF immunity not only caused a significant impairment of the neutralizing antibody response to TBE vaccination but also a reduction of the specific TBE virus neutralizing activities (NT/ELISA-titer ratios). Our results point to a possible negative effect of pre-existing cross-reactive immunity on the outcome of flavivirus vaccination that may also pertain to other combinations of sequential flavivirus infections and/or vaccinations.

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Tickborne Encephalitis Vaccines

Cited by 11 publications

References 137 publications

Tick-borne Encephalitis—Need to know for Professionals outside Endemic Areas

Tick-borne Encephalitis—Need to know for Professionals outside Endemic Areas

Can the booster interval for the tick-borne encephalitis (TBE) vaccine ‘FSME-IMMUN’ be prolonged? — A systematic review

Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination

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