Tight glycaemic control is a key factor in wound healing enhancement strategies in an experimental diabetes mellitus model

O’Sullivan, John B.; Hanson, R.; Chan, Fuan Chiang; Bouchier‐Hayes, David

doi:10.1007/s11845-010-0630-z

Cited by 9 publications

(3 citation statements)

References 16 publications

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“…These findings imply that oral Aloe vera which combines with HUVEC transplantation helps lower blood glucose, thus improving wound angiogenesis and blood flow through an increase in VEGF and a subsequent wound healing promotion. The findings also support earlier reports that good glycemic control is associated with improved wound healing in diabetic animal models and patients with diabetic foot ulcers [35,36,37,38]. Another possible explanation for Aloe vera increasing HUVEC transplantation efficacy is the direct beneficial effect of oral Aloe vera on transplanted [21,22].…”

Section: Discussionsupporting

confidence: 89%

The effects of oral Aloe vera on the efficacy of transplanted human endothelial cells and the expression of matrix metalloproteinases in diabetic wound healing

Kaewsrisung¹,

Sukpat²,

Issarasena³

et al. 2021

Heliyon

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Background: Diabetic wounds are characterized by delayed healing and impaired angiogenesis. Aloe vera and human umbilical vein endothelial cells (HUVECs) are reported to facilitate wound healing, and the former also has hypoglycemic property. Matrix metalloproteinases are enzymes that play a role in diabetic wound pathogenesis. Objective: To investigate whether oral Aloe vera can enhance the efficacy of HUVEC transplantation and inhibit the expression of matrix metalloproteinases in wound healing of diabetic mice. Materials and methods: BALB/c nude mice were randomly assigned into five groups: normal control group, diabetic group (DM), DM transplanted with HUVECs, DM treated with oral Aloe vera, and DM treated with combined HUVECs and oral Aloe vera. Diabetes was induced by streptozotocin. Bilateral full-thickness excision cutaneous wounds were created. At days 7 and 14 post-wounding, the following parameters were determined: blood glucose, wound area, wound perfusion, capillary vascularity, re-epithelialization rate and tissue VEGF levels. Tissue expressions of MMP-2 and MMP-9 were compared between the DM mice and those treated with oral Aloe vera. Results: Over days 7 and 14, Aloe vera exerted glucose-lowering effect in diabetic mice. Higher wound closure rate, blood flow and capillary vascularity, and lower MMP-2 and MMP-9 expressions were observed at both time points in DM treated with Aloe vera group compared with DM group (P < 0.05). Moreover, combined therapy of HUVECs and oral Aloe vera was more effective than Aloe vera or HUVECs alone in increasing VEGF levels, capillary vascularity and wound perfusion. Blood glucose levels were negatively correlated with angiogenesis (P ¼ 0.000. Conclusion: It is suggested that oral Aloe vera enhances the efficacy of HUVEC transplantation on diabetic wound angiogenesis, partly through improving glycemic control. Oral Aloe vera also promotes diabetic wound healing via inhibition of MMP-2 and MMP-9 expressions.

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Section: Discussionsupporting

confidence: 89%

The effects of oral Aloe vera on the efficacy of transplanted human endothelial cells and the expression of matrix metalloproteinases in diabetic wound healing

Kaewsrisung¹,

Sukpat²,

Issarasena³

et al. 2021

Heliyon

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show abstract

“…It is reported that tight glycemic control is a key factor in wound healing in other experimental diabetic models ( 25 ). In the Goto-Kakizaki rat, a non-obese type 2 diabetic model, a glycemic control with metformin-treatment improved the peri-implant wound healing ( 26 ).…”

Section: Discussionmentioning

confidence: 99%

Effects on Glycemic Control in Impaired Wound Healing in Spontaneously Diabetic Torii (SDT) Fatty Rats

Miyajima¹,

S²,

Yamashiro³

et al. 2018

Med Arch

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Introduction: Impaired diabetic wound healing is an important issue in diabetic complications. The present study aims to evaluate the protective eff ect on glycemic control against impaired diabetic wound healing using a diabetic rat model. We investigated the wound healing process and eff ect on the impaired wound repair by glycemic control in the Spontaneously Diabetic Torii (SDT) fatty rat, which is a new animal model of obese type 2 diabetes and may be a good model for study impaired wound healing. Material and methods: Male SDT fatty rats at 15 weeks of age were administered orally with sodium glucose co-transporter (SGLT) 2 inhibitor for 3 weeks. Wounds were induced at 2 weeks after SGLT 2 inhibitor treatment, and the wound areas were periodically examined in morphological and histological analyses. Results:The SDT fatty rats showed a delayed wound healing as compared with the normal rats, but a glycemic control improved the impaired wound healing. In histological analysis in the skin of SDT fatty rats showed severe infi ltration of infl ammatory cell, hemorrhage and many bacterial masses in the remaining and slight fi brosis of crust on skin tissue. Thought that this results skin performance to be a delay of crust formation and regeneration of epithelium; however, these fi ndings were ameliorated in the SGLT 2 inhibitor treated group. Conclusion: Glycemic control is eff ective for treatment in diabetic wounds and the SDT fatty rat may be useful to investigate pathophysiological changes in impaired diabetic wound healing.

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“…In many studies, OH-P levels were measured to assess wound healing and fibrosis (1,16,17). In the study by O'Sullivan et al (18), higher OH-P levels were observed in subjects showing improved wound healing. In studies of intestinal anastomoses, Yamaguchi et al (16) reported elevated levels of OH-P in subjects with better wound healing.…”

Section: Discussionmentioning

confidence: 99%

Investigation of wound healing in rat lung tissues in the postpartum period

Karadayı¹,

Şahin²,

Nadir³

et al. 2012

Experimental and Therapeutic Medicine

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Abstract. To assess the wound healing capabilities of damaged lung tissue in the postpartum period, we investigated the parameters related to wound healing in a rat model of lung damage. Rats were divided into six groups: IA, IB, II, IIIA, IIIB and IV (n=7 in each group). Group IA included rats not in the postpartum period that were sacrificed on the third day after lung injury, group IB included rats not in the postpartum period that were sacrificed on the tenth day after lung injury, group II included rats not in the postpartum period that did not receive lung injury, group IIIA included rats in the postpartum period that were sacrificed on the third day after lung injury, group IIIB included rats in the postpartum period that were sacrificed on the tenth day after lung injury and group IV included rats in the postpartum period without lung injury. Wound healing was evaluated histopathologically and measurements of hydroxyproline levels, serum alanine and glutamine were taken. A significant difference in serum alanine levels was evident between groups IA and IIIA. Significant differences were also observed between serum alanine and glutamine levels in groups IB and IIIB. In conclusion, we demonstrated that serum alanine levels were reduced in the postpartum period following lung injury, which may be expected to negatively impact wound healing in this period. The administration of exogenous alanine for traumatic events occurring during the postpartum period may thus contribute positively to wound healing capabilities during this period.

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Tight glycaemic control is a key factor in wound healing enhancement strategies in an experimental diabetes mellitus model

Cited by 9 publications

References 16 publications

The effects of oral Aloe vera on the efficacy of transplanted human endothelial cells and the expression of matrix metalloproteinases in diabetic wound healing

The effects of oral Aloe vera on the efficacy of transplanted human endothelial cells and the expression of matrix metalloproteinases in diabetic wound healing

Effects on Glycemic Control in Impaired Wound Healing in Spontaneously Diabetic Torii (SDT) Fatty Rats

Investigation of wound healing in rat lung tissues in the postpartum period

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