Tight junction modulation by chitosan nanoparticles: Comparison with chitosan solution

Development and evaluation of thymoquinone-encapsulated chitosan nanoparticles for nose-to-brain targeting: a pharmacoscintigraphic study

“…Similarly, one possible mechanism may be related to the tight junction permeability of the mucosal epithelial cells. 34 A justification for the least permeability of pure drug solution might be its hydrophobicity and possessing negative surface charge. Similarly, Richter and Keipert suggested that the drug should be lipophilic for better permeation through nasal mucosa.…”

The nasal delivery of nanoencapsulated statins – an approach for brain delivery

“…This was not observed for the controls, that is, simvastatin suspension and the solution of the radioisotope itself, where the radioactivity mainly localized in the lungs and GI tract of the animals, as often happens for rodents that are obligate nose breather. It can be hypothesized that the nanoparticle formulation is more effective through both chitosan-mediated mucoadhesion 77 and penetration enhancement via tight-junction opening, 78 but also most likely as a consequence of mucosal biodegradation of the nanoparticle structure. Overall, these processes are able to favor the transmucosal absorption of the radioactivity, independently from the form it may assume: isotopes linked to entire nanoparticles, particle fragments, polysaccharide chains or free from linkage to any of nanoparticle structures.…”

Sintesis Nanopartikel Ekstrak Kulit Manggis Merah Dan Kajian Sifat Fungsional Produk Enkapsulasinya

“…Kitosan lebih banyak dipilih karena memiliki sifat khas, yaitu kemampuan untuk membuka kait antar sel (tight junction) pada membran usus secara sementara (Masotti et al, 2007) sehingga sangat potensial dikembangkan sebagai bahan untuk pembuatan nanopartikel dalam aplikasi penghantar terkontrol suatu zat aktif. Selain itu, kitosan yang memiliki muatan positif pada gugus amonium dapat berinteraksi ionik dengan asam sialat pada membran intestinal saluran cerna (Vllasaliu et al, 2010). Kitosan juga bersifat biodegradable, biokompatibel, food grade, memiliki toksisitas yang rendah (alergi), dan metode preparasi yang sederhana.…”