Tight junction protein claudin 4 in gastric carcinoma and its relation to lymphangiogenic activity

Shareef, Mohamed; Radi, Dina M. Adel; Eid, Asmaa

doi:10.1016/j.ajg.2015.09.008

Cited by 8 publications

(6 citation statements)

References 34 publications

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“…Naso (2020) assessed claudin-4 immunoreactivity in surgical specimens of lung tumors, and reported positivity in 87% of lung adenocarcinomas. Furthermore, claudin-4 was reported by separate reports in most cases of endometrial, breast, gastric, prostatic and ovarian carcinomas (Pan et al, 2013;Abd-Elazeem and Abd-Elazeem, 2015;Shareef et al, 2015;Radi and Abd-Elazeem, 2016;Martín de la Fuente et al, 2018).…”

Section: Discussionmentioning

confidence: 93%

Diagnostic Value of Claudin-4 and EZH2 Immunohistochemistry in Effusion Cytology

Elhosainy

Hafez

Yassin

et al. 2022

Asian Pac J Cancer Prev

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Section: Discussionmentioning

confidence: 93%

Diagnostic Value of Claudin-4 and EZH2 Immunohistochemistry in Effusion Cytology

Elhosainy

Hafez

Yassin

et al. 2022

Asian Pac J Cancer Prev

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“…For example, CLDN-4 expression decreased in GC tissues and was associated with tumor aggressiveness and survival. 17,36 In addition, downregulation of CLDN-18 was associated with the proliferative and invasive potential of GC. 37 In contrast, CLDN-7 was overexpressed in dysplasia and adenocarcinoma tissues but not in the surrounding epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

“…In the case of GC, the expression of TJPs changes to unusual patterns, which affects prognosis or metastasis. For example, CLDN1, 3, and 4 are strongly expressed in intestinal‐type adenocarcinoma, and the strong expression of CLDN4 is associated with decreased survival 16,17 . Moreover, compared to non‐neoplastic mucosal tissues, CLDN7 and 8 are upregulated in GC and are related to lymphatic metastasis 18 …”

Section: Introductionmentioning

confidence: 99%

“…For example, CLDN1, 3, and 4 are strongly expressed in intestinal-type adenocarcinoma, and the strong expression of CLDN4 is associated with decreased survival. 16,17 Moreover, compared to non-neoplastic mucosal tissues, CLDN7 and 8 are upregulated in GC and are related to lymphatic metastasis. 18 The tumor microenvironment (TME) consists of cancer cells and various other components, including infiltrating immune cells, blood vessels, signaling molecules, and extracellular matrix proteins.…”

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confidence: 99%

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Effect of Helicobacter pylori infection and its eradication on the expression of tight junction proteins in the gastric epithelium in relation to gastric carcinogenesis

et al. 2022

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Background Tight junction proteins (TJPs) play a role in epithelial defense mechanisms. However, the effect of Helicobacter pylori (Hp) on TJPs remains unclear. This study aimed to evaluate the expression of TJPs in relation to Hp infection and eradication in gastric carcinogenesis. Methods In total, 510 subjects (284 controls and 226 gastric cancer [GC] patients) were prospectively enrolled in the study. The expression of claudin‐1 and ‐2 (CLDN‐1, ‐2), occludin (OCLN), and tight junction protein 1 (TJP1) was measured based on their Hp infection status in normal corpus mucosa and evaluated following Hp eradication using quantitative real‐time polymerase chain reaction (qPCR) and immunohistochemistry (IHC). Results The expression of TJP1 in Hp+ controls was significantly lower than that in Hp− controls (p = 0.006), whereas it was higher in Hp+ than in Hp− GC patients (p = 0.001). Moreover, the increased expression of TJP1 in Hp+ GC patients was reduced to levels in Hp−within a year after Hp eradication and was maintained for more than 5 years. Furthermore, IHC results for TJP1 were similar to qPCR results. In particular, the higher IHC staining intensity of TJP1 in the cytosol of GC patients (p = 0.019) decreased after Hp eradication (p = 0.040). Conclusion Hp infection affects TJP expression. The high expression of TJP1 in Hp+ GC patients was restored to control levels after Hp eradication, suggesting that TJP1 plays a role in gastric carcinogenesis.

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“…Low expression of claudin 4 is related to lymphangiogenesis in gastric cancer. 6 Low claudin-4 expression is associated with poor prognosis in breast carcinoma in situ and breast cancer. 7 However, its expression does not correlate with staging in OSCC.…”

Section: Introductionmentioning

confidence: 99%

Differential Expression of Claudin in Odontogenic Cysts

Phattarataratip

Sappayatosok

2021

Eur J Dent

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Objective This study aimed to analyze claudin-1, -4, and -7 expression in different types of odontogenic cysts (odontogenic keratocysts [OKCs], dentigerous cysts [DCs], calcifying odontogenic cysts [COCs], and radicular cysts [RCs]) as well as its association with OKC recurrence. Materials and Methods Seventy samples of odontogenic cysts samples were immunohistochemically stained to detect claudin-1, -4, and -7 expression. Patient information and OKC recurrence data were recorded. The staining was analyzed semiquantitatively and categorized based on the pattern and percentage of positively stained cystic epithelial cells. Statistical Analysis Expression of different claudins between groups was analyzed using the Kruskal–Wallis test with Dunn's test, followed by post hoc pairwise comparison. The association between claudin expression and OKC recurrence was analyzed by the Mann–Whitney U test. Correlations among claudin expression were examined with Spearman's correlation coefficient. Level of significance was at p < 0.005. Results Claudin-1 was widely expressed in every odontogenic cyst. Most DCs (50%) expressed claudin-1 in more than 75% of cells, as did RCs (65%), while most OKCs (50%) expressed claudin-1 in 26 to 50% of cells. Most COCs (50%) expressed claudin-1 in 51 to 75% of cells. Every sample of OKC and RC was positive for claudin-4, but no sample showed staining in more than 51% of cells. Every odontogenic cyst was positive for claudin-7. DCs (35%), OKCs (55%), and RCs (40%) mostly showed staining in 26 to 50% of cells. High claudin-1 expression was shown in COCs, DCs, and RCs, while low expression of claudin-4 was shown in every odontogenic cyst. For claudin-7, the expression is high only in COCs. Claudin-1 and -4 was significantly different among each odontogenic cyst. High expression of claudin-1 was correlated with OKC recurrence. The correlations of claudin-1 with claudin-7 expression and claudin-4 with claudin-7 expression were significant in DCs. In COCs, claudin-1 and claudin-7 expression was significantly correlated. Conclusions The expression of claudin-1, -4, and -7 was present in every odontogenic cyst, but the proportion of positive staining cells was different. Expression of claudin-1 is associated with OKC recurrence. Dysregulation of claudin expression may play a pathogenic role in cyst pathogenesis.

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Tight junction protein claudin 4 in gastric carcinoma and its relation to lymphangiogenic activity

Cited by 8 publications

References 34 publications

Diagnostic Value of Claudin-4 and EZH2 Immunohistochemistry in Effusion Cytology

Diagnostic Value of Claudin-4 and EZH2 Immunohistochemistry in Effusion Cytology

Effect of Helicobacter pylori infection and its eradication on the expression of tight junction proteins in the gastric epithelium in relation to gastric carcinogenesis

Differential Expression of Claudin in Odontogenic Cysts

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