2021
DOI: 10.3389/fimmu.2021.688961
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TIGIT Induces (CD3+) T Cell Dysfunction in Colorectal Cancer by Inhibiting Glucose Metabolism

Abstract: T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) is an immunosuppressive receptor expressed on the surface of immune cells, suppressing immune responses by activating the intracellular negative regulatory signals. TIGIT plays an important role in the pathogenesis of various tumors, but its immune escape in colorectal cancer remains unclear. We found that the proportion of CD3+TIGIT+ T cells was increased in peripheral blood and cancer tissue in colorectal cancer patients … Show more

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Cited by 27 publications
(18 citation statements)
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“…TIGIT overexpression has been found in the cellular microenvironment of several tumors, including lung ( 111 ), kidney ( 112 ), liver ( 113 ), glioma ( 114 , 115 ), melanoma ( 116 ), colorectal carcinomas ( 117 ), gastric cancer ( 118 ), and neuroblastomas ( 119 ). TIGIT expression was found to be strongly associated with poor prognosis in colorectal cancer and positively correlated with pathological stages in renal clear cell carcinoma ( 120 ), kidney renal papillary cell carcinoma, and uveal melanoma ( 121 , 122 ).…”
Section: Tigit In Cancer Progressionmentioning
confidence: 99%
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“…TIGIT overexpression has been found in the cellular microenvironment of several tumors, including lung ( 111 ), kidney ( 112 ), liver ( 113 ), glioma ( 114 , 115 ), melanoma ( 116 ), colorectal carcinomas ( 117 ), gastric cancer ( 118 ), and neuroblastomas ( 119 ). TIGIT expression was found to be strongly associated with poor prognosis in colorectal cancer and positively correlated with pathological stages in renal clear cell carcinoma ( 120 ), kidney renal papillary cell carcinoma, and uveal melanoma ( 121 , 122 ).…”
Section: Tigit In Cancer Progressionmentioning
confidence: 99%
“…Furthermore, high TIGIT expression was linked to advanced disease, early recurrence, and lower survival rates ( 156 ), and with advanced TNM stage and better disease-free survival (DFS) in colorectal cancer patients with mismatch repair deficiency ( 157 ). Another study discovered a higher TIGIT + CD3 + T cell subpopulation in the peripheral blood and cancer tissue of colorectal cancer patients than in healthy donors ( 121 ). TIGIT + CD3 + T cells were exhausted cells with decreased proliferation, cytokine production, and glucose metabolism ( 121 ).…”
Section: Tigit In Cancer Progressionmentioning
confidence: 99%
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“…In addition, MYC/PVT1 signaling induced immune surveillance via CD8 + TILs and peripheral blood mononuclear cells in CRCs [ 49 ]. As for G2M checkpoint, in-vitro co-culture assays of T cells and HCT-116 colorectal cancer cells reflected that immune checkpoint TIGIT blockade suppressed G2M transit [ 50 ]. Overall, these tumor proliferation-related pathways might also exert tumor immunity associated effects on the TIME of CRC, and the underlying mechanism deserved future investigation.…”
Section: Resultsmentioning
confidence: 99%
“…Besides, the overexpression of TIGIT in infiltrating lymphocytes exhibited functional failure and hyporesponsive state, which was associated with the advanced stage of tumor ( 51 ). High expression of TIGT could lead to impaired glucose metabolism of T cells, and blocking TIGIT restored T cell activity and function ( 101 ). Furthermore, the interaction between TIGIT and CD155 participated in regulating CD8+ T cell effector via the activation of the NF-κB signaling pathway ( 102 ).…”
Section: Role Of Cd155/tigit In Digestive System Cancersmentioning
confidence: 99%