Tigroid background in fine‐needle aspiration cytology of clear cell sarcoma

Rau, Aarathi R.; Kini, Hema; Verghese, R.

doi:10.1002/dc.20368

Cited by 22 publications

(18 citation statements)

References 7 publications

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“…The available reports of ALK1 LBCL in the cytology literature focus on potential pitfalls of diagnosis such as the possibility of mistakenly diagnosing this disease as a carcinoma secondary to epithelioid morphology with cohesiveness/clustering, pseudo-acinar or pseudo-papillary formations, and abundant cytoplasm. [31][32][33][34][35][36][37] To our knowledge, the current case represents the first reported FNA of ALK1 LBCL with tigroid backgrounds. [28][29][30] Tigroid backgrounds are classically present in smears and scrape preparations made from seminomatous germ cell tumors and are described as having delicate, blue-gray, frothy background material dispersed in a pattern of interlacing ribbons, felt reminiscent of a tiger's coat pattern.…”

Section: Discussionmentioning

confidence: 99%

“…This phenomenon has been previously reported in tumor types other than seminoma, including other malignancies such as clear cell carcinomas of the female genital tract, glycogen-rich squamous cell carcinomas, fetal adenocarcinomas of the lung, clear cell carcinomas of the salivary glands, and clear cell sarcomas. [31][32][33][34][35][36][37] To our knowledge, the current case represents the first reported FNA of ALK1 LBCL with tigroid backgrounds. Out of interest, Periodic Acid Schiff (PAS) and Periodic Acid Schiff with diastase (DPAS) stains were performed on tissue sections from the biopsy specimen in this case.…”

Section: Discussionmentioning

confidence: 99%

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Anaplastic lymphoma kinase positive large B‐cell lymphoma: Literature review and report of an endoscopic fine needle aspiration case with tigroid backgrounds mimicking seminoma

Sakr

Cruise

Chahal

et al. 2016

Diagnostic Cytopathology

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Anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK+ LBCL) is a rare distinct type of non-Hodgkin's lymphoma that arises in association with alterations of the ALK gene. This distinct disease entity is typically associated with an aggressive clinical course and appears in light microscopic preparations as a monomorphic population of large, immunoblast-like cells. In this report, we describe a case of ALK+ LBCL diagnosed by transgastric endoscopic ultrasound-guided fine needle aspiration (EUS FNA) of splenic hilar lymph nodes. Modified Giemsa stained direct smears from the FNA sample demonstrated large lesional cells with foamy cytoplasm and macronucleoli admixed with small lymphocytes in tigroid backgrounds, mimicking the cytologic appearance of seminoma. Ancillary immunohistochemical studies subsequently confirmed the diagnosis of ALK+ LBCL with the lesional cells being immunoreactive for CD138, VS38c, MUM1, ALK1, and lambda light chain. The cohesiveness of the cells, the cellular morphology, and the tigroid backgrounds were all pitfalls for accurate diagnosis of this rare specific type of lymphoid malignancy by cytology. To our knowledge this is the first case report detailing the diagnosis of ALK+ LBCL by EUS FNA and the first report describing a glycogen-rich tigroid background in direct FNA smears. Establishing a refined diagnosis in cases of this rare form of LBCL is necessary, as therapies targeting ALK may be of value in clinical management. Diagn. Cytopathol. 2017;45:148-155. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Anaplastic lymphoma kinase positive large B‐cell lymphoma: Literature review and report of an endoscopic fine needle aspiration case with tigroid backgrounds mimicking seminoma

Sakr

Cruise

Chahal

et al. 2016

Diagnostic Cytopathology

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“…4 However, this lacy, reticulated, background is a well-known feature described as ''tiger-striped or astrakhan'' in aspirates of seminoma due to the disruption of glycogen-rich cytoplasm. 5 ''Tigroid'' background is considered an extremely helpful morphologic feature for diagnosis of seminoma, 6,7 clear cell adenocarcinoma of the female genital tract, and glycogen-rich squamous cell carcinoma.…”

mentioning

confidence: 99%

Clear cell sarcoma: Cytopathologic finding of a “tigroid” background

Eluri

Ali

2010

Diagnostic Cytopathology

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“…There have been only a very small number of reports about cytologic features of soft tissue‐type CCS . These reports have noted rounded nuclei with a tendency for size imbalance, a prominent eosinophilic nucleolus, and polygonal or rarely fusiform cells with abundant clear cytoplasm.…”

Section: Discussionmentioning

confidence: 99%

Imprint cytology of clear cell sarcoma‐like tumor of the gastrointestinal tract in the small intestine: A case report

Kato

Ichihara

Gotoda

et al. 2017

Diagnostic Cytopathology

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Clear cell sarcoma-like tumor of the gastrointestinal tract (CCSLGT) is an extremely rare malignant neoplasm in the digestive tract. Its cytomorphologic features have never previously been reported. Here, we describe a case of CCSLGT, including its cytologic examination findings. A 47-year-old woman presented with a mass in the small intestine, which was resected and sent for imprint cytology. Imprint smears revealed tumor cells with light eosinophilic or clear cytoplasm in a necrotic background. Many of the tumor cells were arranged in a perivascular growth with a pseudopapillary formation, and there were some non-neoplastic osteoclast-like giant cells. Histological examination revealed solid nests and a pseudopapillary pattern of the tumor cells with clear or pale eosinophilic cytoplasm and large nuclei with small nucleoli. Immunohistochemistry showed positive for vimentin, S-100, and SOX-10, and negative for SMA, c-KIT, cytokeratin, HMB-45, and MelanA. The EWSR1 gene split signal was detected by reverse transcriptase fluorescence in situ hybridization, and EWSR1-CREB1 gene fusion was indicated by reverse transcriptase polymerase chain reaction analysis. From these findings, we diagnosed the tumor as CCSLGT. To best of our knowledge, this is the first description of the imprint cytology features of CCSLGT.

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Tigroid background in fine‐needle aspiration cytology of clear cell sarcoma

Cited by 22 publications

References 7 publications

Anaplastic lymphoma kinase positive large B‐cell lymphoma: Literature review and report of an endoscopic fine needle aspiration case with tigroid backgrounds mimicking seminoma

Anaplastic lymphoma kinase positive large B‐cell lymphoma: Literature review and report of an endoscopic fine needle aspiration case with tigroid backgrounds mimicking seminoma

Clear cell sarcoma: Cytopathologic finding of a “tigroid” background

Imprint cytology of clear cell sarcoma‐like tumor of the gastrointestinal tract in the small intestine: A case report

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