Tiliacora triandra attenuates cisplatin triggered hepatorenal and testicular toxicity in rats by modulating oxidative inflammation, apoptosis and endocrine deficit

Abstract

Purpose: Cisplatin (CIS) is a platinum based anticancer drug that has demonstrated significant efficacy against various types of cancers. Unfortunately, this drug is also famous for its severe side effects on delicate organs. Herein this study examined the hepatorenal and testicular protective effects of TiTE against CIS-induced hepatorenal and testicular insults. Methods: Rats were administered with TiTE (250 and 500 mg/kg body weight) for 4 weeks, while a single dose of CIS (2.5 mg/kg body weight) was injected once per week from week 2 to week 4. Results: Treatment with TITE significantly attenuated CIS-induced increases in serum creatinine, blood urea nitrogen (BUN), uric acid, alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Furthermore, TiTE treatment also decreased oxidative stress (MDA) inflammations (TNF-α, IL-1β, IL-6, NF-κB) and apoptosis (caspase-3 activity) and restored hepatorenal and testicular antioxidant defense (SOD, CAT and GPx) in CIS treated rats. Additionally, the TiTE improved sperm count, motility and viability, and ameliorated the reduced serum levels of testosterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) in CIS-injected rats. TiTE also curtailed hepatorenal and testicular histological changes in CIS treated rats. Conclusion: The findings from the study indicated that TiTE displayed hepatorenal and testicular protective effects via inhibition of oxidative stress-mediated inflammation and endocrine imbalance in rats.

The antioxidant, anti-inflammatory, and anti-apoptotic effects of sesamin against cisplatin-induced renal and testicular toxicity in rats

“…Several studies have explored the mechanisms behind CP-induced toxicity. After entering tubular cells, CP undergoes a series of reactions that lead to the formation of more toxic metabolites [ 2 ]. It induces oxidative stress through tipping the balance between free radical production and elimination.…”

Melatonin Mitigates Cisplatin-Induced Ovarian Dysfunction via Altering Steroidogenesis, Inflammation, Apoptosis, Oxidative Stress, and PTEN/PI3K/Akt/mTOR/AMPK Signaling Pathway in Female Rats

“…Chemotherapeutic agents are extremely important in combating cancers; however, the prevalence of side effects associated with these drugs is worrisome. Cisplatin is a frontline choice for a variety of malignancies [23]. Only 15-20% of patients respond to its treatment owing to the activation of some survival signaling pathways and inactivation of cisplatin by the thiol-conjugation leading to CP resistance.…”

Study of Traditional Uses, Extraction Procedures, Phytochemical Constituents, and Pharmacological Properties of Tiliacora triandra

“…e authors reported that the rats' group treated just with cisplatin presented a higher body weight and lower kidney, liver, and testes weight compared with the control (normal saline) and with the group of T. triandra treatment. Meanwhile, the biochemical serum analysis revealed that the T. triandra treatment suppressed the increment in some biomarkers related to kidney, liver, and testicular damage such as creatinine, aspartate aminotransferase, luteinizing hormone (LH), and testosterone [34]. e mechanism involves improved sperm count, motility, and viability and ameliorated the reduced serum levels of testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH).…”

“…e mechanism involves improved sperm count, motility, and viability and ameliorated the reduced serum levels of testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH). It was reported that the phytochemicals phenolic and flavonoids from leaves were able to attenuate cisplatin triggered hepatorenal in cisplatin-injected male Wistar rats within four weeks' time [34] (Table 3). It is crucial to note that the extraction conditions could modify the antioxidant properties of T. triandra, and it is vital to evaluate the adequate conditions in terms of the concentration of the molecules [44].…”