Time Cells in the Hippocampus Are Neither Dependent on Medial Entorhinal Cortex Inputs nor Necessary for Spatial Working Memory

Sabariego, Marta; Schonwald, Antonia; Boublil, Brittney L.; Zimmerman, David T.; Ahmadi, Siavash; Gonzalez, Nailea; Leibold, Christian; Clark, Robert E.; Leutgeb, Jill K.; Leutgeb, Stefan

doi:10.1016/j.neuron.2019.04.005

Cited by 56 publications

(96 citation statements)

References 77 publications

(122 reference statements)

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“…A number of spiking parameters (spike amplitude and ISI during bursts) and spatial firing parameters (information content, spatial coherence, field size) were altered whereas others (spike peak-to-trough duration, infield mean firing rates, peak firing rate) were unaffected. These effects are similar to those reported in previous studies ( Brun et al, 2008 ; Hales et al, 2014 ; Kanter et al, 2017 ; Sabariego et al, 2019 ; Schlesiger et al, 2018 ) indicating that place cell firing does not exclusively depend on MEC inputs. Overdispersion, a parameter that reflects the excess variance inherent to place cell discharge ( Fenton and Muller, 1998 ) was found to be higher in MEC rats.…”

Section: Discussionsupporting

confidence: 91%

Medial entorhinal cortex lesions induce degradation of CA1 place cell firing stability when self-motion information is used

Philippe

Cauter

Poucet

et al. 2020

Brain and Neuroscience Advances

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The entorhinal–hippocampus network plays a central role in navigation and episodic memory formation. To investigate these interactions, we examined the effect of medial entorhinal cortex lesions on hippocampal place cell activity. Since the medial entorhinal cortex is suggested to play a role in the processing of self-motion information, we hypothesised that such processing would be necessary for maintaining stable place fields in the absence of environmental cues. Place cells were recorded as medial entorhinal cortex–lesioned rats explored a circular arena during five 16-min sessions comprising a baseline session with all sensory inputs available followed by four sessions during which environmental (i.e. visual, olfactory, tactile) cues were progressively reduced to the point that animals could rely exclusively on self-motion cues to maintain stable place fields. We found that place field stability and a number of place cell firing properties were affected by medial entorhinal cortex lesions in the baseline session. When rats were forced to rely exclusively on self-motion cues, within-session place field stability was dramatically decreased in medial entorhinal cortex rats relative to SHAM rats. These results support a major role of the medial entorhinal cortex in processing self-motion cues, with this information being conveyed to the hippocampus to help anchor and maintain a stable spatial representation during movement.

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Section: Discussionsupporting

confidence: 91%

Medial entorhinal cortex lesions induce degradation of CA1 place cell firing stability when self-motion information is used

Philippe

Cauter

Poucet

et al. 2020

Brain and Neuroscience Advances

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“…One recent study did not find evidence for time cell sequences during a 60s-delay (Sabariego et al, 2019). In our task, one lap of the route took approximately 4.5 minutes on average; comparable to the 250s-duration of a trial in Tsao et al (2018).…”

Section: Discussionmentioning

confidence: 45%

Structuring Time in Human Lateral Entorhinal Cortex

Bellmund

Deuker

Doeller

2018

Preprint

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Remembering event sequences is central to episodic memory and presumably supported by the hippocampal-entorhinal region. We previously demonstrated that the hippocampus maps spatial and temporal distances between events encountered along a route through a virtual city , but the content of entorhinal mnemonic representations remains unclear. Here, we demonstrate that multi-voxel representations in the anterior-lateral entorhinal cortex (alEC) -the human homologue of the rodent lateral entorhinal cortex -specifically reflect the temporal event structure after learning. Holistic representations of the sequence structure related to memory recall and the timeline of events could be reconstructed from entorhinal multi-voxel patterns. Our findings demonstrate representations of temporal structure in the alEC; dovetailing with temporal information carried by population signals in the lateral entorhinal cortex of navigating rodents and alEC activations during temporal memory retrieval. Our results provide novel evidence for the role of the alEC in representing time for episodic memory.

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“…Time cell ensembles change over minutes and days (Mau et al, 2018), but their firing has been investigated predominantly in the context of short delays in the range of seconds. One recent study did not find evidence for time cell sequences during a 60s-delay (Sabariego et al, 2019). In our task, one lap of the route took approximately 4.5 min on average; comparable to the 250s-duration of a trial in Tsao et al (2018).…”

Section: Discussionmentioning

confidence: 98%

Mapping sequence structure in the human lateral entorhinal cortex

Bellmund

Deuker

Doeller

2019

eLife

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Remembering event sequences is central to episodic memory and presumably supported by the hippocampal-entorhinal region. We previously demonstrated that the hippocampus maps spatial and temporal distances between events encountered along a route through a virtual city (Deuker et al., 2016), but the content of entorhinal mnemonic representations remains unclear. Here, we demonstrate that multi-voxel representations in the anterior-lateral entorhinal cortex (alEC) — the human homologue of the rodent lateral entorhinal cortex — specifically reflect the temporal event structure after learning. Holistic representations of the sequence structure related to memory recall and the timeline of events could be reconstructed from entorhinal multi-voxel patterns. Our findings demonstrate representations of temporal structure in the alEC; dovetailing with temporal information carried by population signals in the lateral entorhinal cortex of navigating rodents and alEC activations during temporal memory retrieval. Our results provide novel evidence for the role of the alEC in representing time for episodic memory.

show abstract

Time Cells in the Hippocampus Are Neither Dependent on Medial Entorhinal Cortex Inputs nor Necessary for Spatial Working Memory

Cited by 56 publications

References 77 publications

Medial entorhinal cortex lesions induce degradation of CA1 place cell firing stability when self-motion information is used

Medial entorhinal cortex lesions induce degradation of CA1 place cell firing stability when self-motion information is used

Structuring Time in Human Lateral Entorhinal Cortex

Mapping sequence structure in the human lateral entorhinal cortex

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