Time-Course Changes in Optic Nerve Head Blood Flow and Retinal Nerve Fiber Layer Thickness in Eyes with Open-angle Glaucoma

Kiyota, Naoki; Shiga, Yukihiro; Omodaka, Kazuko; Pak, Kyongsun; Nakazawa, Toru

doi:10.1016/j.ophtha.2020.10.010

Cited by 35 publications

(29 citation statements)

References 55 publications

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“…Decreased ocular blood flow was also shown to be correlated with structural glaucomatous progression, as indicated by retinal and optic nerve changes [33]. A recent retrospective longitudinal study revealed that reduced blood flow in the ONH precedes glaucomatous neurodegeneration in POAG patients [34]. The vascular hypothesis is thus based on the reduced perfusion pressure, faulty vascular autoregulation or loss of neurovascular coupling, which leads to optic nerve degeneration in glaucoma [35].…”

Section: Vascular Hypothesismentioning

confidence: 99%

Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update

et al. 2022

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Glaucoma is one of the leading causes of irreversible blindness. It is generally caused by increased intraocular pressure, which results in damage of the optic nerve and retinal ganglion cells, ultimately leading to visual field dysfunction. However, even with the use of intraocular pressure-lowering eye drops, the disease still progresses in some patients. In addition to mechanical and vascular dysfunctions of the eye, oxidative stress, neuroinflammation and excitotoxicity have also been implicated in the pathogenesis of glaucoma. Hence, the use of natural products with antioxidant and anti-inflammatory properties may represent an alternative approach for glaucoma treatment. The present review highlights recent preclinical and clinical studies on various natural products shown to possess neuroprotective properties for retinal ganglion cells, which thereby may be effective in the treatment of glaucoma. Intraocular pressure can be reduced by baicalein, forskolin, marijuana, ginsenoside, resveratrol and hesperidin. Alternatively, Ginkgo biloba, Lycium barbarum, Diospyros kaki, Tripterygium wilfordii, saffron, curcumin, caffeine, anthocyanin, coenzyme Q10 and vitamins B3 and D have shown neuroprotective effects on retinal ganglion cells via various mechanisms, especially antioxidant, anti-inflammatory and anti-apoptosis mechanisms. Extensive studies are still required in the future to ensure natural products’ efficacy and safety to serve as an alternative therapy for glaucoma.

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Section: Vascular Hypothesismentioning

confidence: 99%

Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update

et al. 2022

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“…The authors found older age, high pulse rate, and whether the damaged quadrant was superior or temporal to be risk factors for faster perfusion parameter deterioration. When two or more risk factors were obtained, MT decrease preceded RNFLT decrease [ 62 ]. This finding indicates that in a subgroup of glaucoma patients, reduced ONH perfusion is part of the pathogenesis.…”

Section: Hemodynamic Alterations In Glaucoma Patientsmentioning

confidence: 99%

Vascular Aspects in Glaucoma: From Pathogenesis to Therapeutic Approaches

Mursch‐Edlmayr

Bolz

Strohmaier

2021

IJMS

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Glaucomatous optic neuropathies have been regarded as diseases caused by high intraocular pressure for a long time, despite the concept of vascular glaucoma dating back to von Graefe in 1854. Since then, a tremendous amount of knowledge about the ocular vasculature has been gained; cohort studies have established new vascular risk factors for glaucoma as well as identifying protective measures acting on blood vessels. The knowledge about the physiology and pathophysiology of the choroidal, retinal, as well as ciliary and episcleral circulation has also advanced. Only recently have novel drugs based on that knowledge been approved for clinical use, with more to follow. This review provides an overview of the current vascular concepts in glaucoma, ranging from novel pathogenesis insights to promising therapeutic approaches, covering the supply of the optic nerve head as well as the aqueous humor production and drainage system.

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“…Glaucoma is an irreversible, chronic cause of visual field (VF) impairment worldwide, 1 and is considered as a multifactorial disease: high intraocular pressure (IOP), 2 age, 3 myopia, 3 low ocular perfusion, 4 , 5 and oxidative stress. 6 , 7 These factors are believed to lead to damage of the optic nerve fibers of the retinal ganglion cells (RGCs) at the site of the lamina cribrosa.…”

Section: Introductionmentioning

confidence: 99%

Correlation Between Enlargement of Retinal Nerve Fiber Defect Angle in En Face Imaging and Visual Field Progression

Takahashi

Omodaka

Nakazawa

et al. 2022

Trans. Vis. Sci. Tech.

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Time-Course Changes in Optic Nerve Head Blood Flow and Retinal Nerve Fiber Layer Thickness in Eyes with Open-angle Glaucoma

Cited by 35 publications

References 55 publications

Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update

Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update

Vascular Aspects in Glaucoma: From Pathogenesis to Therapeutic Approaches

Correlation Between Enlargement of Retinal Nerve Fiber Defect Angle in En Face Imaging and Visual Field Progression

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