Time Course of Changes in Leptin Levels and their Relationships with Oxidant Status Biomarkers in Pregnant Women with Obesity

Malti, Nassima; Merzouk, Hafida; Bouhmama, Loubna; Saker, Meriem; Elhabiri, Mourad; Cherrak, Sabri

doi:10.7860/jcdr/2020/43475.13640

Cited by 2 publications

(4 citation statements)

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“…Leptin The present review demonstrated that levels of leptin are elevated in obese women and correlate positively with BMI at both systemic and local levels throughout the periconceptional period [35,40,42,45,50,51,62,65,66,68,71,74,[76][77][78]. The results are consistent with other studies, confirming the effect of obesity on increasing leptin levels [91,92].…”

Section: Adipokinessupporting

confidence: 91%

“…First trimester: The levels of leptin were higher in obese (five studies) and overweight/obese (three studies) women compared to women of normal weight [58,65,66,68,71,74,77,78]. Also, BMI positively correlated with maternal leptin levels in five studies [35,58,62,66,76].…”

Section: Adipokinesmentioning

confidence: 91%

“…First trimester: Higher levels of insulin were observed in obese (four studies) and overweight/obese (one study) women compared to normal weight or overweight women [67,[69][70][71]78]. HOMA-IR and HOMA2-IR scores (used to assess insulin resistance) were higher in obese women compared to normal weight or overweight women in three studies; whereas the ISHOMA score, which assesses insulin sensitivity, was lower [58,65,67,70].…”

Section: Insulinmentioning

confidence: 95%

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Periconceptional biomarkers for maternal obesity: a systematic review

Hojeij

Rousian

Sinclair

et al. 2022

Rev Endocr Metab Disord

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Periconceptional maternal obesity is linked to adverse maternal and neonatal outcomes. Identifying periconceptional biomarkers of pathways affected by maternal obesity can unravel pathophysiologic mechanisms and identify individuals at risk of adverse clinical outcomes. The literature was systematically reviewed to identify periconceptional biomarkers of the endocrine, inflammatory and one-carbon metabolic pathways influenced by maternal obesity. A search was conducted in Embase, Ovid Medline All, Web of Science Core Collection and Cochrane Central Register of Controlled Trials databases, complemented by manual search in PubMed until December 31st, 2020. Eligible studies were those that measured biomarker(s) in relation to maternal obesity, overweight/obesity or body mass index (BMI) during the periconceptional period (14 weeks preconception until 14 weeks post conception). The ErasmusAGE score was used to assess the quality of included studies. Fifty-one articles were included that evaluated over 40 biomarkers. Endocrine biomarkers associated with maternal obesity included leptin, insulin, thyroid stimulating hormone, adiponectin, progesterone, free T4 and human chorionic gonadotropin. C-reactive protein was associated with obesity as part of the inflammatory pathway, while the associated one-carbon metabolism biomarkers were folate and vitamin B12. BMI was positively associated with leptin, C-reactive protein and insulin resistance, and negatively associated with Free T4, progesterone and human chorionic gonadotropin. Concerning the remaining studied biomarkers, strong conclusions could not be established due to limited or contradictory data. Future research should focus on determining the predictive value of the optimal set of biomarkers for their use in clinical settings. The most promising biomarkers include leptin, adiponectin, human chorionic gonadotropin, insulin, progesterone and CRP.

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Section: Adipokinessupporting

confidence: 91%

Section: Adipokinesmentioning

confidence: 91%

Section: Insulinmentioning

confidence: 95%

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Periconceptional biomarkers for maternal obesity: a systematic review

Hojeij

Rousian

Sinclair

et al. 2022

Rev Endocr Metab Disord

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“…Studies in obese individuals have shown a correlation between leptin levels and oxidative stress parameters such as nitric oxide (NO), superoxide anion (O 2 − . ), peroxynitrite, MDA , hydroperoxides, protein carbonyl (PC) contents, GSH, and SOD [106][107][108]. Studies in which hyperleptinemia was induced by the administration of exogenous leptin in nonobese animals suggest that leptin increases the level of systemic oxidative stress [109,110].…”

Section: Leptin Signaling Pathways Pomc;pro-opiomelanocortin Socs3; Intracellular Suppressor Of Cytokine Signal 3 Ptp1b; Protein Tyrosinementioning

confidence: 99%

Leptin and Its Role in Oxidative Stress and Apoptosis: An Overview

Gelen¹,

Kükürt²,

Şengül³

et al. 2021

Role of Obesity in Human Health and Disease

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Adipose tissue (AT) in the body plays a very important role in the regulation of energy metabolism. AT regulates energy metabolism by secreting adipokines. Some of the adipokines released are vaspin, resistin, adiponectin, visfatin and omentin, and leptin. In addition to regulating energy metabolism, leptin plays a role in the regulation of many physiological functions of the body such as regulation of blood pressure, inflammation, nutrition, appetite, insulin and glucose metabolism, lipid metabolism, coagulation, and apoptosis. Among all these physiological functions, the relationship between leptin, oxidative stress, and apoptosis has gained great importance recently due to its therapeutic effect in various types of cancer. For this reason, in this study, the release of leptin, its cellular effects and its effect on oxidative stress, and apoptosis are discussed in line with current information.

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Time Course of Changes in Leptin Levels and their Relationships with Oxidant Status Biomarkers in Pregnant Women with Obesity

Cited by 2 publications

References 0 publications

Periconceptional biomarkers for maternal obesity: a systematic review

Periconceptional biomarkers for maternal obesity: a systematic review

Leptin and Its Role in Oxidative Stress and Apoptosis: An Overview

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