Time-Course of Changes in Choroidal Thickness after Complete Mydriasis Induced by Compound Tropicamide in Children

Li, Zhouyue; Zeng, Junwen; Jin, Wei�; Wen, Lin; Lan, Weizhong; Yang, Xiao

doi:10.1371/journal.pone.0162468

Cited by 16 publications

(18 citation statements)

References 37 publications

(44 reference statements)

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“…During the mydriasis induced by topical use of muscarinic antagonists, both the thickness and curvature of the lens decrease, the anterior chamber depth increases and the axial length decreases in humans 21 – 23 , resulting in a hyperopic shift of the eye. Changes in choroidal thickness (ChT) during the topical administration of muscarinic antagonists was also observed in previous studies of human trials 21 , 24 – 26 with some studies reporting a thickening choroid 21 , 26 and others demonstrating a thinning choroid 24 , 25 . These results indicate that posterior segment of the eye undergoes dimensional changes after treatment with muscarinic antagonists, which may contribute to the refractive changes during the mydriasis.…”

Section: Introductionsupporting

confidence: 57%

The effect of topical administration of cyclopentolate on ocular biometry: An analysis for mouse and human models

Huang

Xie

et al. 2017

Sci Rep

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Mydriasis with muscarinic antagonists have been used routinely prior to retinal examination and sometimes prior to refractive measurements of the mouse eye. However, biometric changes during topical administration of muscarinic antagonists have not been fully investigated in mice and humans. We found that the mouse eyes treated with cyclopentolate developed a hyperopia with a reduction in both the vitreous chamber depth and axial length. In humans, prior to the cyclopentolate treatment, a 6D accommodative stimulus produced a myopic shift with a reduced anterior chamber depth, choroidal thickness and anterior lens radius of curvature and an increase in lens thickness. After the cyclopentolate treatment, human eyes developed a hyperopic shift with an increased anterior chamber depth and anterior lens radius of curvature and a reduced lens thickness. Therefore, the biometric changes associated with this hyperopic shift were mainly located in the posterior segment of the eye in mice. However, it is the anterior segment of the eye that plays a main role in the hyperopic shift in human subjects. These results further indicate that mouse eyes do not have accommodation which needs to be taken into account when they are used for the study of human refractive errors.

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Section: Introductionsupporting

confidence: 57%

The effect of topical administration of cyclopentolate on ocular biometry: An analysis for mouse and human models

Huang

Xie

et al. 2017

Sci Rep

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“…; Li et al. ,b). It is found that the change of a relative peripheral myopic defocus after OK lens wear in most myopic eyes might act as a possible mechanism for myopia control (Kang & Swarbrick ), but the underlying mechanism is stilled unknown.…”

Section: Discussionmentioning

confidence: 99%

“…; Li et al. ,b). However, as observed in current and previous studies, great individual variation in response exists (Cho & Cheung ; Swarbrick et al.…”

Section: Discussionmentioning

confidence: 99%

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Change in subfoveal choroidal thickness secondary to orthokeratology and its cessation: a predictor for the change in axial length

Cui

et al. 2018

Acta Ophthalmologica

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Purpose: To investigate changes in subfoveal choroidal thickness (SFChT) during orthokeratology (Ortho-K) lens wear and after its cessation and the association of short-term change in SFChT with the long-term eye elongation in Ortho-K subjects. Design: A prospective clinical trial. Methods: Fifty myopic children aged between 9 and 14 years were enrolled. Twenty-nine subjects continuously wore Ortho-K lens for 12 months and discontinued for 1 month. Twenty-one subjects wearing single vision distance spectacles for 12 months were included as the control group. SFChT was assessed using optical coherence tomography. Ocular parameters, including axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT) and apical corneal power (ACP), were also measured. Results: After 12 months of follow-up, AL elongation was larger and SFChT change was smaller in the control group compared to the Ortho-K group (both p < 0.001). In the Ortho-K group, SFChT increased by 16 lm from baseline at the 1-month visit (p < 0.001), and the magnitude of choroidal thickening remained unchanged at the 6-and 12-month visit (p = 0.289). One month after discontinuation of Ortho-K lens, SFChT and ocular parameters of the anterior segment, including ACP, CCT and ACD recovered to baseline level (All p > 0.05), and AL increased by 0.23 AE 0.18 mm compared to baseline (p = 0.018). SFChT change at 1-month was negatively associated with AL change at 13-month (standard b, À0.581, p = 0.001) after adjusting for other influencing factors, including baseline age and the ocular parameters. Conclusion: Subfoveal ChT (SFChT) significantly increased after short-term Ortho-K lens treatment and the increase maintained throughout the period of treatment. One month after Ortho-K lens cessation, SFChT, ACP, CCT and ACD returned to baseline. Short-term response in SFChT is associated with long-term change in AL in children undergoing Ortho-K lens and may be a predictor for the effectiveness of the treatment.

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“…Ultimately, we have to take into consideration that the choroid has intrinsic dynamic changes that can influence its thickness. CT variation upon mannitol infusion [42], mydriasis induced by tropicamide [43], single administration of coffee [12], after water drinking tests [7], and after hemodialysis [18, 19] has already been reported. Also, studies have shown that the choroid can change its volume and thereby its thickness over a few days by five possible mechanisms [32]: changes in osmotic gradient [44], changes in vascular permeability [45], shift of aqueous humor flow from the anterior chamber to the choroid [46], moving retinal fluid across the retinal pigment epithelium into the choroid [47], and changes in the tonus of nonvascular smooth muscle cells that are controlled by both sympathetic and parasympathetic inputs [48].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Glycemia on Choroidal Thickness in Different Stages of Diabetic Retinopathy

et al. 2020

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Objective: The purpose of this study was to evaluate the influence of renal and glycemic parameters on choroidal thickness (CT) in patients with diabetes with and without diabetic retinopathy (DR). Methods: This cross-sectional study included patients with and without diabetes. Patients underwent comprehensive ocular examination. CT was obtained using spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging (EDI) mode. Clinical parameters were body mass index, mean arterial pressure, glycated hemoglobin, fasting plasma glucose, estimated glomerular filtration rate, and capillary plasma glucose (CPG) a few minutes before EDI-SD-OCT. Results: The study included 275 participants: 42 with diabetes and no DR, 43 with mild nonproliferative diabetic retinopathy (NPDR), 46 with moderate NPDR, 39 with severe NPDR, 24 with proliferative diabetic retinopathy (PDR), 40 with previous panretinal photocoagulation (PRP) treatment for DR, and 41 without diabetes. The diabetic patients had thinner subfoveal CT than the nondiabetic participants (280.5 ± 83.4 vs. 327.1 ± 48.8 µm, p < 0.001). After multivariable adjustment, CT was significantly correlated with age, DR stage, and CPG. In patients with mild and moderate NPDR, a higher level of CPG was associated with thicker CT. This relationship was not found in patients with PDR. Conclusion: CPG had the strongest correlation with CT in patients with NPDR (mild, moderate, and severe), but not in PDR and PRP PDR patients. Our study suggests that the glucose level at the time of the test should be aggregated to other systemic and ocular parameters, such as age and axial length, when studying the choroid using SD-OCT.

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Time-Course of Changes in Choroidal Thickness after Complete Mydriasis Induced by Compound Tropicamide in Children

Cited by 16 publications

References 37 publications

The effect of topical administration of cyclopentolate on ocular biometry: An analysis for mouse and human models

The effect of topical administration of cyclopentolate on ocular biometry: An analysis for mouse and human models

Change in subfoveal choroidal thickness secondary to orthokeratology and its cessation: a predictor for the change in axial length

The Effect of Glycemia on Choroidal Thickness in Different Stages of Diabetic Retinopathy

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