Time course of liver lipid infiltration in ovariectomized rats: Impact of a high-fat diet

Paquette, Amélie; Shinoda, Motoo; Lhoret, R. Rabasa; Prud’homme, Denis; Lavoie, Jean‐Marc

doi:10.1016/j.maturitas.2007.08.002

Cited by 73 publications

(64 citation statements)

References 32 publications

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“…In the present study, comparisons between OVX and rats without estrogen deficiency (S-S, O-EX-E 2 , and O-E 2 ) revealed that serum TAG levels in S-S, O-EX-E 2 , and O-E 2 rats were higher than levels measured in O-S rats. The results were similar to those reported by Paquette et al (2007b) who found that plasma TAG levels in Sham and OVX-E 2 rats were higher than levels measured in OVX rats. In addition, 12 weeks of treadmill exercise training did not affect serum TAG levels in O-S and O-E 2 rats, but did lead to a decrease in S-S rats.…”

Section: Discussionsupporting

confidence: 91%

“…The change in serum lipids is directly decided by lipid synthesis and metabolism. Significant accumulation of liver TAG has been recently reported in female Sprague-Dawley rats 3-13 weeks after ovariectomy (Paquette et al 2007b). Corriveau et al (2008) reported that the addition of resistance training to the restrictive diet treatment synergistically resulted in an important decrease in liver TAG accumulation induced by OVX.…”

Section: Discussionmentioning

confidence: 98%

“…In addition, the effect of OVX on serum TAG levels is also controversial. Some studies have reported a reduction in serum TAG levels after OVX (Barsalani et al 2008;Paquette et al 2007b), while others have not observed any changes (Bitto et al 2009;Sanchez-Mateos et al 2007;Meli et al 2004). These contradictory results could be due to factors such as the diet, the subject's metabolic conditions and the duration of the study.…”

Section: Discussionmentioning

confidence: 99%

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Effects of treadmill exercise training on liver fat accumulation and estrogen receptor alpha expression in intact and ovariectomized rats with or without estrogen replacement treatment

Wang

Duan

et al. 2010

Eur J Appl Physiol

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To explore the mechanism(s) of exercise training on ovariectomized (OVX)-induced liver lipid disorder, we observed effects of treadmill training on liver fat accumulation and ER alpha expression in intact and ovariectomized rats. Sixty female rats were randomly assigned to six groups: Sham sedentary (S-S), Sham exercised (S-EX), ovariectomized sedentary (O-S), ovariectomized exercised (O-EX), ovariectomized injected subcutaneously with 17beta-estradiol (E(2)) (O-E(2)), and ovariectomized treated with E(2) and exercise (O-E(2)-EX). Twelve weeks after intervention, OVX resulted in significantly higher body weight gain, intra-abdominal fat mass, serum levels of total cholesterol (TC), and liver triacylglycerol (TAG) concentrations and ER alpha expression than S-S group, while the relative uterus and liver mass, serum levels of E(2), TAG, and the ratio of high density lipoprotein (HDL) to TC were markedly lower in O-S group. All of these changes were decreased in O-S rats after treatment with E(2) alone with the exception of serum TC and HDL-C levels and liver ER alpha expression. Exercise alone significantly reversed the effect of OVX on serum E(2), the ratio of HDL-C to TC and the liver and intra-abdominal fat accumulation in OVX rats. The addition of E(2) to exercise induced the same uterus and lipid profile as E(2) alone. Moreover, an additive effect of exercise and E(2) was observed on liver ER alpha expression in Sham or OVX rats. In conclusion, treadmill training alone could prevent liver fat accumulation in OVX rats and the regulation of exercise on liver ER alpha expression in both OVX and Sham rats needs the presence of physical estrogen levels.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of treadmill exercise training on liver fat accumulation and estrogen receptor alpha expression in intact and ovariectomized rats with or without estrogen replacement treatment

Wang

Duan

et al. 2010

Eur J Appl Physiol

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“…Control rats had an increment of 20% in body mass. Our results are in agreement with the literature, which defines body mass gain as a characteristic of gonadal function loss (18)(19)(20)(21) and indicates an important role for estradiol in controlling fat accumulation and obesity. However, the reason for the difference between the EB and control groups is not clear.…”

supporting

confidence: 93%

“…Among its many functions, adipocyte secretes cytokines, some of which are important for the homeostasis of glucose and lipid metabolism, and/or the maintenance of the vessel wall (21)(22)(23). A potent angiogenic peptide, VEGF circulating levels are positively correlated with fat mass in humans (24).…”

mentioning

confidence: 99%

Fat tissue morphology of long-term sex steroid deficiency and estrogen treatment in female rats

Carlos

Costa

Armada

et al. 2011

Fertility and Sterility

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Two weeks of high‐fat feeding disturb lipid and cholesterol molecular markers

Magri-Tomaz

Melbouci

Mercier

et al. 2018

Cell Biochemistry & Function

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Metabolic disorders are often associated with liver steatosis and increased plasma cholesterol levels. However, the link between excessive lipid accumulation and impairments in cholesterol metabolism remains uninvestigated in the liver. Short term of high‐fat diet (HFD) was previously shown to promote excessive lipid accumulation prior to the development of metabolic disorders. The present study intended to characterize how increases in liver fat alter the expression of several key regulators of hepatic cholesterol metabolism in response to a short‐term HFD. Wistar rats were randomly submitted either to HFD (n = 8) or a regular chow diet (n = 8) for 14 days. Increases in triglycerides were highly significant (P < 0.01) in the liver but marginal in the plasma of HFD rats. In contrast, the HFD resulted in higher (P < 0.01) cholesterol levels in plasma but not in liver samples. Gene expression of key markers involved in cholesterol uptake (LDL particles) including low‐density lipoprotein receptor‐related protein‐1 (LRP‐1) and protein convertase subtilisin/kexin type 9 (PCSK9) along with ATP‐binding cassette, superfamily G, member 5 (ABCG5) involved in cholesterol exportation via bile ducts was found to be higher (P < 0.05) in response to the HFD. In contrast, expression of 3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGCR), involved in cholesterol synthesis, was downregulated in the liver. The data support the concept that excessive accumulation of lipids promptly alters the expression of key genes regulating cholesterol metabolism in the liver. On a clinical point of view, this indicates that increases in plasma cholesterol occur after a short‐term HFD.

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Time course of liver lipid infiltration in ovariectomized rats: Impact of a high-fat diet

Cited by 73 publications

References 32 publications

Effects of treadmill exercise training on liver fat accumulation and estrogen receptor alpha expression in intact and ovariectomized rats with or without estrogen replacement treatment

Effects of treadmill exercise training on liver fat accumulation and estrogen receptor alpha expression in intact and ovariectomized rats with or without estrogen replacement treatment

Fat tissue morphology of long-term sex steroid deficiency and estrogen treatment in female rats

Two weeks of high‐fat feeding disturb lipid and cholesterol molecular markers

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