Time Courses in the Blood and Antivasospasm Effects of Fasudil Hydrochloride and the Metabolite in Patients with Subarachnoid Hemorrhage

Chronologic changes of fasudil hydrochloride and hydroxyfasudil in cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage

“…The T 1/2 FH was 20 minutes in serum and 120 minutes in CSF, compared with 15 minutes in serum in healthy volunteers. 10 Kazuki et al 11 reported that T 1/2 FH was 16.9 minutes in the serum of patients with SAH. There seems to be no difference in T 1/2 FH in healthy people and the patients studied.…”