Time-Domain Quantification of Multiple-Quantum-Filtered 23Na Signal Using Continuous Wavelet Transform Analysis

Serrai, Haçène; Borthakur, Arijitt; Senhadji, Lotfi; Reddy, Ravinder; Bansal, Navin

doi:10.1006/jmre.1999.1947

Cited by 8 publications

(3 citation statements)

References 14 publications

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“…The water is suppressed by about a factor of 10.000. The SNR of the NAA peak (in vivo data) in the CWT water suppressed spectrum is about 17:1, which is well above the SNR of MRS signals quantified elsewhere (21,26,27).…”

Section: Resultsmentioning

confidence: 94%

Water Modeled Signal Removal and Data Quantification in Localized MR Spectroscopy Using a Time-Scale Postacquistion Method

Serrai

Senhadji

Clayton

et al. 2001

Journal of Magnetic Resonance

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Section: Resultsmentioning

confidence: 94%

Water Modeled Signal Removal and Data Quantification in Localized MR Spectroscopy Using a Time-Scale Postacquistion Method

Serrai

Senhadji

Clayton

et al. 2001

Journal of Magnetic Resonance

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“…Sodium MRI can be used in anatomical imaging applications in brain, tumors and cardiac cycle (25)(26)(27)(28)(29). Special attention was focused on achieving intracellular sodium images.…”

Section: Clinical Sodium Mri Trialsmentioning

confidence: 99%

Contrast enhancement methods in sodium MR imaging: a new emerging technique

Sharma¹,

Sharma²,

Kwon³

et al. 2009

JBiSE

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Background: In the last decade, sodium mag-netic resonance imaging was investigated for its potential as a functional cardiac imaging tool for ischemia. Later interest was developed in contrast enhancement for intracellular sodium. Little success was reported to suppress extracellular sodium resulting in the intracellular sodium MRI image acquisition using quantum filters or sodium transition states as contrast properties. Now its clinical application is ex-panding as a new challenge in brain and other cancer tumors. Contrast enhancement: We highlight the physical principles of sodium MRI in three different pulse sequences using filters (single quantum, multiple quantum, and triple quantum) meant for sodium contrast enhancement. The optimization of scan parameters, i.e. times of echo delay (TE), inversion recovery (TI) periods, and utility of Dysprosium (DyPPP) shift contrast agents, enhances contrast in sodium MRI images. Inversion recovery pulse sequence without any shift reagent measures the intracellular sodium concentration to evaluate ischemia, apoptosis and membrane integrity. Membrane integrity loss, apoptosis and malignancy are results of growth factor loss and poor epithelial capability related with MRI visible intracellular sodium concentration. Applications and limitations: The sodium MR imaging technical advances reduced scan time to distinguish intracellular and extracellular sodium signals in malignant tumors by use of quantum filter techniques to generate 3D sodium images without shift regents. We observed the association of malignancy with increased TSC, and reduced apoptosis and epithelial growth factor in breast cancer cells. The validity is still in question. Conclusion: Different modified sodium MRI pulse sequences are research tools of sodium contrast enhancement in brain, cardiac and tumor imaging. The optimized MRI scan pa-rameters in quantum filter techniques generate contrast in intracellular sodium MR images without using invasive contrast shift agents. Still, validity and clinical utility are in quest

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“…Serrai et al 14 consider an FID as a noisy sum of damped complex sinusoids and quantify it by an iterative procedure: (1) a spectral line is extracted from the time-scale plane by the method of Delprat et al, 11 using the CWT with a Morlet wavelet; (2) 16 In all cases, the results are accurate, even in the presence of broad resonances and overlapping peaks. However, no independent validation of the accuracy is available, and the VARPRO comparison is made on a single real-world example, without using any prior knowledge and no validation of precision.…”

Section: Quantitationmentioning

confidence: 99%

Wavelets and related time‐frequency techniques in magnetic resonance spectroscopy

2001

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Time-Domain Quantification of Multiple-Quantum-Filtered 23Na Signal Using Continuous Wavelet Transform Analysis

Cited by 8 publications

References 14 publications

Water Modeled Signal Removal and Data Quantification in Localized MR Spectroscopy Using a Time-Scale Postacquistion Method

Water Modeled Signal Removal and Data Quantification in Localized MR Spectroscopy Using a Time-Scale Postacquistion Method

Contrast enhancement methods in sodium MR imaging: a new emerging technique

Wavelets and related time‐frequency techniques in magnetic resonance spectroscopy

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