Radio Frequency Identification (RFID) is a key enabling technology of Internet of Things (IoTs) and has attracted much research attention in recent years. RFID can support automatic information tracing and management during the management process in many fields. A typical application of RFID is modern warehouse management, where products are attached with RFID tags and the inventory is managed by retrieving tag IDs. Many practical applications require searching a group of tags to determine whether they are in the system or not. The existing studies on tag searching have mainly focused on improving time efficiency and paid little attention to energy efficiency that is extremely important for active tags powered by built-in batteries. To fill in this gap, this paper investigates the tag searching problem from the angle of energy efficiency. We first propose an Energy-efficient tag Searching protocol in Multiple reader RFID systems, namely ESiM, which pushes per tag energy consumption to the limit as each tag needs to exchange only one bit