Time-Kill Assay Results for a Linalool-Hinokitiol-Based Eyelid Cleanser for Lid Hygiene

Abstract

This linalool-hinokitiol-based eyelid cleanser may be helpful in the outpatient setting for patients with presurgical, blepharitis, punctal plug and dry eye, and in the inpatient setting for patients who are allergic to iodine, or as an adjunct to povidone-iodine.

Synthesis and Evaluation of Troponoids as a New Class of Antibiotics

“…The broad anti-bacterial activity of β-thujaplicin (Hinokitiol, 47 ) and γ-thujaplicin ( 48 ) was reported several decades ago. 8 , 28 , 29 Our results revealed modest inhibition of both Gram-positive bacteria ( S. aureus ) and Gram-negative rods ( E. coli and A. banmannii ), which is consistent with previous reports ( Table S1 ). Two α-HT, 261 and 262 , also showed broad inhibition against both Gram-positive and Gram-negative bacteria ( Table 2 ).…”

Prevention, diagnosis, and management of acute postoperative bacterial endophthalmitis

“…Recently, time-kill results for a linalool-hinokitiolbased eyelid skin cleanser proved superior to povidone-iodine 10% against S aureus and MRSA. 64 While bacteria may gain intraocular access during surgery, 65,66 it has been demonstrated that povidone-iodine conjunctival irrigation effectively prevents intracameral contamination during phacoemulsification. 67 An evidence-based assessment of endophthalmitis prophylaxis found that preoperative povidone-iodine antisepsis received the highest rating and was the only measure that gained a "B" grade (meaning moderately important to clinical outcome).…”

Hinokitiol, a tropolone derivative, inhibits mouse melanoma (B16-F10) cell migration and in vivo tumor formation

“…This major bioactive compound is used in certain health care products, such as safe preservatives for toothpaste, cosmetics, hair tonics, mouth care gel, eyelid cleanser, hair restorers, skin lotions, and body soap, because of its multiple biological activities (Gilbard et al, 2010;Nagao and Sata, 2011). Hinokitiol has also been reported to regulate immune cell function by inhibiting the production of tumor necrosis factor-α from lipopolysaccharide-stimulated macrophages through the inhibition of NF-κB activity (Byeon et al, 2008).…”