Time reproduction deficits in essential tremor patients

Pedrosa, David J.; Nelles, Christian; Maier, Franziska; Eggers, Carsten; Burghaus, Lothar; Fink, Gereon R.; Wittmann, Marc; Timmermann, Lars

doi:10.1002/mds.26630

Cited by 9 publications

(5 citation statements)

References 38 publications

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“…Yet the high representation of tremor related activity in more ventral recordings may be compatible with cerebellar input (Hirai and Jones, 1989; Hua and Lenz, 2005). Cerebellothalamic dysfunction underlying essential tremor has long been postulated and may parsimoniously explain many clinical signs encountered in essential tremor such as eye movement abnormalities, dysmetria or specific cognitive deficits such as verbal fluency reduction or disturbed time perception (Stoodley and Schmahmann, 2010; Pedrosa et al , 2014a, 2016). Alternatively, one may speculate about cortico-thalamic or cortico-baso-thalamic contributions as there exist extensive reciprocal connections with the thalamus (Buzsaki and Draguhn, 2004), and these candidates have already been variously implicated in essential tremor (Raethjen and Deuschl, 2012, Pedrosa et al , 2017).…”

Section: Discussionmentioning

confidence: 99%

A functional micro-electrode mapping of ventral thalamus in essential tremor

Pedrosa

Brown

Cagnan

et al. 2018

Brain

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Deep brain stimulation enables the delivery of therapeutic interventions to otherwise inaccessible areas of the brain while, at the same time, offering the unique opportunity to record from these same regions in awake patients. The posterior ventrolateral thalamus has become a reliable deep brain stimulation target for medically-refractory patients suffering from essential tremor. However, the contribution of the thalamus in essential tremor, and even whether posterior ventrolateral thalamus is the optimal target, remains a matter of ongoing debate. There are several lines of evidence supporting clusters of activity within the posterior ventrolateral thalamus that are important for tremor emergence. In this study we sought to map the functional properties of these clusters through microelectrode recordings during deep brain stimulation surgery. Data were obtained from 10 severely affected patients with essential tremor (12 hemispheres) undergoing deep brain stimulation surgery. Our results demonstrate power and coherence maxima located in the inferior posterior ventrolateral thalamus and immediate ventral region. Moreover, we identified distinct yet overlapping clusters of predominantly efferent (driving) and afferent (feedback) activity, with a preference for more efferent contributors, consistent with a net role in the driving of tremor output. Finally, we demonstrate that resolvable thalamic spiking activity directly relates to background activity and that the strength of tremor may be dictated by phase relationships between efferent and afferent pockets in the posterior ventrolateral thalamus. Taken together, these results provide important evidence for the role of the inferior posterior ventrolateral thalamus and its border region in essential tremor pathophysiology. Such results progress our mechanistic understanding and promote the adoption of next-generation therapies such as high resolution segregated deep brain stimulation electrodes.

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Section: Discussionmentioning

confidence: 99%

A functional micro-electrode mapping of ventral thalamus in essential tremor

Pedrosa

Brown

Cagnan

et al. 2018

Brain

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“…ALFF is an index used to characterize regional cerebral function (Wang et al, 2018). One study (Pedrosa et al, 2016) documents furthermore temporal underestimation in a reproduction task for both sub-second and supra-second durations in ET.…”

Section: Essential Tremormentioning

confidence: 99%

Time Processing, Interoception, and Insula Activation: A Mini-Review on Clinical Disorders

et al. 2020

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Time processing is a multifaceted skill crucial for managing different aspects of life. In the current work, we explored the relationship between interoception and time processing by examining research on clinical models. We investigated whether time processing deficits are associated with dysfunction of the interoceptive system and/or insular cortex activity, which is crucial in decoding internal body signaling. Furthermore, we explored whether insular activation predicts the subjective experience of time (i.e., the subjective duration of a target stimulus to be timed). Overall, our work suggests that alteration of the interoceptive system could be a common psychophysiological hallmark of mental disorders affected by time processing deficits.

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“…Recent meta-analyses 2 – 7 have demonstrated the strong involvement of the supplementary motor area (SMA) in time processing, which has traditionally been considered to contribute to the voluntary control of movement. Strong evidence has been provided by studies of patients with movement and motor system disorders such as Parkinson’s disease (PD) and tremor, which are characterized by dysfunctions in time processing 8 – 11 . Pastor et al 8 demonstrated that patients with PD underestimated the duration of a time interval in a verbal time estimation task, and exhibited overproduction of time intervals when required to reproduce a short time sample.…”

Section: Introductionmentioning

confidence: 99%

Subjective time compression induced by continuous action

Ueda

Shimoda

2021

Sci Rep

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Increasing evidence indicates that voluntary actions can modulate the subjective time experience of its outcomes to optimize dynamic interaction with the external environment. In the present study, using a temporal reproduction task where participants reproduced the duration of an auditory stimulus to which they were previously exposed by performing different types of voluntary action, we examined how the subjective time experience of action outcomes changed with voluntary action types. Two experiments revealed that the subjective time experience of action outcomes was compressed, compared with physical time, if the action was performed continuously (Experiment 1), possibly enhancing the experience of controlling the action outcome, or if the action was added an extra task-unrelated continuous action (Experiment 2), possibly reflecting different underlying mechanisms from subjective time compression induced by the task-related continuous action. The majority of prior studies have focused on the subjective time experience of action outcomes when actions were performed voluntarily or not, and no previous study has examined the effects of differences in voluntary action types on the subjective time experience of action outcomes. These findings may be useful in situations in which people wish to intentionally compress their own time experience of daily events through their voluntary actions.

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Time reproduction deficits in essential tremor patients

Abstract: Data suggest impaired temporal processing in essential tremor, corroborating evidence for specific cognitive deficits. © 2016 International Parkinson and Movement Disorder Society.

Cited by 9 publications

References 38 publications

A functional micro-electrode mapping of ventral thalamus in essential tremor

A functional micro-electrode mapping of ventral thalamus in essential tremor

Time Processing, Interoception, and Insula Activation: A Mini-Review on Clinical Disorders

Subjective time compression induced by continuous action

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