Time series analysis revealed prognostic value of continuous nasopharyngeal SARS-CoV-2 nucleic acid quantification for COVID-19: A retrospective study of &gt;3000 COVID-19 patients from 2 centers

Wu, Zhiyuan; Yang, Can; Shen, Yutao; Zhang, Qingyun; Tang, Xuemei; Wang, Di; Xu, Yu; Cao, Guojun; Song, Xiaodong; Ma, Yanchun; Fan, Huajie; Lu, Hailong; Li, Yaju; Li, Xiangyu; Shen, Yiqin; Zhang, Chen; Zhu, Min; Teng, Xiaoyan; Du, Yuchen; Guan, Ming

doi:10.1016/j.cca.2023.117227

Cited by 2 publications

(1 citation statement)

References 30 publications

(26 reference statements)

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“…Chest CT severity score (CT-SS) has been recognized as an important method to assess the severity of lung involvement and disease prognosis, but its predictive validity is equally unsatisfactory [9,14]. Third, reverse transcription-polymerase chain reaction (RT-PCR) for nasopharyngeal swab detection remains the diagnostic standard for COVID-19, and the dynamic alteration of cycling threshold (Ct) values of SARS-CoV-2 can be considered as a prognostic marker for COVID-19 pneumonia [15]. However, some COVID-19 patients have negative RT-PCR results at the early stage of disease onset despite the presence of typical viral pneumonia on chest CT [16], which means that CT values of SARS-CoV-2 are controversial for the prognosis prediction of such patients.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of SOFA combined with chest CT severity score in patients with critical COVID-19 pneumonia: a retrospective study

Fang,

Yu,

Zhao

et al. 2024

Preprint

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Background: Either sequential organ failure assessment (SOFA) score or chest CT severity score (CT-SS) is often used alone to evaluate the prognosis of patients with critical coronavirus disease 2019 (COVID-19), but each of them has intrinsic deficiency. Herein, we attempted to investigate the predictive value of the combination of SOFA and CT-SS for the prognosis of COVID-19. Materials and Methods: A single-center retrospective study was performed in the Second Affiliated Hospital of Zhejiang University School of Medicine from December 2022 to January 2023. Patients with critical COVID-19 pneumonia were divided into two groups of survival or non-survival of hospitalization. The data including clinical characteristics, CT-SS, SOFA score, laboratory results on admission day were collected and analyzed. In addition, the predictive value of SOFAscore, chest CT-SS, or their combination for in-hospital mortality of COVID-19 pneumonia were compared by receiver operating characteristic (ROC) curve. Results: A total of 424 patients with a mean age of 75.46 years and a major proportion of male (69.10%) were finally enrolled, and the total in-hospital mortality was 43.40% (184/424). In comparison with survival group, significant higher proportions of older age (>75 years), comorbidities including obesity, diabetes, and cerebrovascular disease, more needs of mechanical ventilation and continuous renal replacement therapy (CRRT) were observed in the non-survival group (all P﹤0.05). In addition, non-survival patients had a higher value of creatinine, procalcitonin, C-reactive protein, interleukin-6 , SOFA score , CT-SS (all P﹤0.05) on admission day. Multivariate logistic regression analysis further showed that older age, obesity, diabetes, SOFA score, CT-SS, mechanical ventilation, and lymphocytopenia (all P﹤0.05) were independently related with in-hospital mortality. Moreover, the area under the curve (AUC) of combination of SOFA score and chest CT-SS became significant higher than their respective alone (P＜0.01). Conclusion: A simple combination of SOFA scorewith chest CT-SS on admission elicits a better predictive value for in-hospital mortality of critical COVID-19 patients, which could also serve as a promising indicator for prognosis prediction of other severe lung diseases like severe pneumonia and acute lung injury.

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Section: Introductionmentioning

confidence: 99%

Prognostic value of SOFA combined with chest CT severity score in patients with critical COVID-19 pneumonia: a retrospective study

Fang,

Yu,

Zhao

et al. 2024

Preprint

View full text Add to dashboard Cite

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Testing for SARS-CoV-2: lessons learned and current use cases

Theel,

Kirby,

Pollock

2024

Clin Microbiol Rev

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SUMMARY The emergence and worldwide dissemination of SARS-CoV-2 required both urgent development of new diagnostic tests and expansion of diagnostic testing capacity on an unprecedented scale. The rapid evolution of technologies that allowed testing to move out of traditional laboratories and into point-of-care testing centers and the home transformed the diagnostic landscape. Four years later, with the end of the formal public health emergency but continued global circulation of the virus, it is important to take a fresh look at available SARS-CoV-2 testing technologies and consider how they should be used going forward. This review considers current use case scenarios for SARS-CoV-2 antigen, nucleic acid amplification, and immunologic tests, incorporating the latest evidence for analytical/clinical performance characteristics and advantages/limitations for each test type to inform current debates about how tests should or should not be used.

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Time series analysis revealed prognostic value of continuous nasopharyngeal SARS-CoV-2 nucleic acid quantification for COVID-19: A retrospective study of >3000 COVID-19 patients from 2 centers

Cited by 2 publications

References 30 publications

Prognostic value of SOFA combined with chest CT severity score in patients with critical COVID-19 pneumonia: a retrospective study

Prognostic value of SOFA combined with chest CT severity score in patients with critical COVID-19 pneumonia: a retrospective study

Testing for SARS-CoV-2: lessons learned and current use cases

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