Time to conception and time to live birth in women with unexplained recurrent miscarriage

Kaandorp, Stef P.; Mens, Thijs E. van; Hutten, Barbara A.; Hof, Michel H.; Post, Joris A. M. van der; Veen, Fulco van der; Goddijn, Mariëtte

doi:10.1093/humrep/deu052

Cited by 32 publications

(24 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The association of maternal age and number of preceding miscarriages with further outcome has been addressed in several reviews [ 8 , 9 , 36 ] and recent studies [ 10 , 11 , 37 , 38 ]. Since inclusion and exclusion criteria and study designs differ, close comparison of the results is not possible.…”

Section: Discussionmentioning

confidence: 99%

“… 665/987 (67.4 %) (after 3rd mc 75 %) n.a. 20-29: 80 % 30–34:60–70 % 35–39: 60 % 40 +: 45 % Kaandorp et al [ 38 ] Additional evaluation Prospective ALIFE-trial 251 Cumulative 34 (22–43) 3 (2–15) No No Yes 13 % of couples 100 weeks + pregnancy outcome 213/251 (84.8 %) 139/251 (55.4 %) 139/213 (65.3 %) n.a. Kling et al [ 17 ] Observational cohort study 228 Cumulative 32 (21–39) 3 (3–7) Yes preclinical to 15th week Yes No 24 months + pregnancy outcome 206/228 (90.4 %) 174/228 (76.4 %) 174/206 (84.5 %) 21–29: 80 % 30–34: 80 % 35–39: 60 % n.a.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Two-year outcome after recurrent first trimester miscarriages: prognostic value of the past obstetric history

Kling

Magez

Hedderich

et al. 2016

Arch Gynecol Obstet

View full text Add to dashboard Cite

PurposeRecurrent miscarriage (RM) is a stressful condition which gives rise to extensive diagnostic evaluation and is seen as a potentially curable maternal disease. Nevertheless, epidemiological data have shown that outcome is related to fertility. In addition to maternal age and number of preceding miscarriages, further markers derived from the past history may support counselling.MethodsObservational trial comprising 228 couples who were referred between 1996 and 2003 for immunological evaluation at maternal ages 20–39 years after three or more spontaneously conceived primary first trimester miscarriages. They were interviewed in 2005, ongoing pregnancies were followed up until birth in 2006. Past obstetric history was correlated with 2 year cumulative pregnancy and delivery rates (CPR, CDR).ResultsCPR and CDR were 206/228 (90.4 %) and 174/228 (76.4 %). Duration of infertility was associated with lower CPR (up to 3/>3 years, p < 0.01), whereas age and number of preceding losses inversely correlated with CDR (<35 years/35–39 years, p < 0.002; 3/>3 miscarriages, p < 0.002). Detection of an embryonic heart beat in 2–3 of the first three miscarriages resulted in favourable outcome (CPR: p < 0.02, CDR: p < 0.002). Prognosis was excellent in younger fertile women after three miscarriages where vital signs had been detected; under less favourable conditions not only risks for further miscarriage, but also for secondary infertility were elevated.ConclusionSecondary infertility is a feature of RM. Embryonic vital signs in preceding pregnancies are prognostic markers and should be regarded as a strong confounding factor in trials on therapeutic interventions. Prevention may be more appropriate than treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Two-year outcome after recurrent first trimester miscarriages: prognostic value of the past obstetric history

Kling

Magez

Hedderich

et al. 2016

Arch Gynecol Obstet

View full text Add to dashboard Cite

show abstract

“…It affects 1-5 % of all couples trying to conceive (6,7) .The commonly accepted defi nition stipulates that the foetus or embryo should weigh 500 g or less, a stage that corresponds to a gestational age of up to 20 weeks (8). Although many different factors related to RM, including chromosomal, anatomical and endocrine aberrations, and infection, have been investigated, 50 % of RM cases are still without identifi able factors and labelled as unexplained (unexplained RM) (8).…”

Section: Introductionmentioning

confidence: 99%

Association of angiogenic cytokines (VEGF-A and VEGF-C) and clinical characteristic in women with unexplained recurrent miscarriage

Bagheri¹,

Kumar²,

Kamath³

et al. 2017

BLL

View full text Add to dashboard Cite

INTRODUCTION: Recurrent miscarriage (RM) defi ned as 2 or more spontaneous miscarriage before 20 weeks of gestation, affects at least 1 % of couples trying to conceive. In over 50 % of cases, the cause of the loss of pregnancy remains unexplained. Reduced expression of Angiogenic factors such as: vascular endothelial growth factor (VEGF-A) and VEGF-C has been linked with spontaneous miscarriage, likely due to defective foetal and placental angiogenesis. AIMS AND OBJECTIVES: To investigate the relationships between serum level of VEGF-A and VEGF-C with clinical characteristic in women with URM and compare to pregnant and healthy women. MATERIALS AND METHODS: A case-control study, which was conducted between 90 non-pregnant women with history of RM, age-matched with 70 non-pregnant women without history of recurrent abortion with at least one child (controls) and 70 pregnant women without history of recurrent abortion with at least one child (controls). Those with unexplained RM were eligible. Demographic and Anthropometric data were retrieved by pre-test questionnaire and serum level of VEGF-A and VEGF-C measured by ELISA kit. RESULTS: This study showeds that maternal levels of VEGF-A and VEGF-C were distinctly lower in RSA (189.87±88.1 vs 238.8±99.6) compared to healthy (239.1±99.7 vs 275.5±133.08) and pregnant (301.5±76.4 vs 402.5±128.6) women as control groups. Univariate analysis demonstrated that clinical characteristic factors were signifi cantly associated with concentration of VEGF-A and VEGF-C in cases and controls. CONCLUSIONS: Our fi ndings suggest that these molecules could be used as potential predictive markers of miscarriage in these women presenting with URM (Tab. 4, Fig. 5, Ref. 40). Text in PDF www.elis.sk.

show abstract

“…Indeed, in the ALIFE trial, women who were not pregnant at time of randomization were included in an analysis of time to conceive. 58 The median time to pregnancy for factor V Leiden carriers was shorter, at 11 weeks vs 23 weeks for noncarriers. This difference remained statistically significant after correction for potential confounders.…”

Section: Inherited Thrombophilia and Pregnancy Complicationsmentioning

confidence: 96%

Inherited thrombophilia: a double-edged sword

Middeldorp

2016

Hematology

View full text Add to dashboard Cite

Inherited thrombophilia is a blood coagulation disorder that increases the risk for venous thromboembolism (VTE). During the last decades, the practice of testing has evolved from testing selected populations, leading to high perceived risks, to broad testing for various conditions that included VTE, arterial thrombosis, and pregnancy complications. Because results of such tests usually do not guide treatment decisions, not testing patients with VTE for inherited thrombophilia is on the "Choosing Wisely" list endorsed by multiple specialty societies, including ASH. Inherited thrombophilia can be regarded a double-edged sword, as despite the rationale not to test, it is still being performed frequently. Another way of seeing inherited thrombophilia as a double-edged sword lies in its 2-sided association with reproduction, both in men and in women. Current areas of research are whether women with inherited thrombophilia and pregnancy complications benefit from anticoagulant therapy with regard to improving the chance of a successful pregnancy. Potential effects of inherited thrombophilia, most notably factor V Leiden, on improved embryo implantation in women and sperm counts in men are intriguing, but are currently poorly understood.

show abstract

Time to conception and time to live birth in women with unexplained recurrent miscarriage

Abstract: This cohort study was nested in the randomized controlled trial; ALIFE study (Current Controlled Trials number, ISRCTN 58496168).

Cited by 32 publications

References 23 publications

Two-year outcome after recurrent first trimester miscarriages: prognostic value of the past obstetric history

Two-year outcome after recurrent first trimester miscarriages: prognostic value of the past obstetric history

Association of angiogenic cytokines (VEGF-A and VEGF-C) and clinical characteristic in women with unexplained recurrent miscarriage

Inherited thrombophilia: a double-edged sword

Contact Info

Product

Resources

About