Time to desaturation in the 6-min walking distance test predicts 24-hour oximetry in COPD patients with a PO2 between 60 and 70mmHg

García‐Talavera, Ignacio; García, Concepción Hernández; Macario, Ciro Casanova; de-Torres, Juan P.; Celli, Bartolomé R.; Aguirre‐Jaime, Armando

doi:10.1016/j.rmed.2008.02.004

Cited by 36 publications

(30 citation statements)

References 26 publications

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“…11,12 In a previous study we found that early desaturation is more important than non-early desaturation. 8 The walk time to S pO 2 Ͻ 90% is also valuable information, because early versus non-early desaturation status is prognostic. Early desaturation is associated with substantial desaturation during 24-hour oximetry, which means that early desaturators might desaturate during most of their activities of daily living.…”

Section: Discussionmentioning

confidence: 99%

“…Early desaturation is associated with substantial desaturation during 24-hour oximetry, which means that early desaturators might desaturate during most of their activities of daily living. 8 Early desaturation has true clinical importance in that early desaturators are more likely to need long-term home oxygen within 5 years, and therefore have a poorer prognosis. Our early desaturators desaturated more deeply (see Fig.…”

Section: Discussionmentioning

confidence: 99%

“…In a previous study in which we evaluated walk distance and oxygen saturation, we analyzed the walk-distance to S pO 2 Ͻ 90% and time to S pO 2 Ͻ 90%, and identified 2 groups of desaturators: early desaturators (S pO 2 dropped below 90% within the first minute of the 6-min walk), and non-early desaturators (S pO 2 did not drop below 90% within the first minute of the 6-min walk). 8 The early desaturators had greater desaturation during activities of daily living, as measured via 24-hour oximetry. However, the clinical consequences of early desaturation in the 6-min walk test are unknown.…”

Section: Introductionmentioning

confidence: 96%

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Time to Desaturation Less Than One Minute Predicts the Need for Long-Term Home Oxygen Therapy

et al. 2011

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BACKGROUND: Exercise desaturation in patients with COPD is a pathophysiological phenomenon that is not wholly understood and whose clinical consequences are still unclear. METHODS: Eighty-three patients with moderate to severe COPD and P aO 2 > 60 mm Hg who desaturated during the 6-min walk test were followed for 5 years. Forty-eight patients had early desaturation (S pO 2 fell below 90% less than one minute after starting the walk test). Spirometry, blood-gas measurements, and 6-min walk tests were performed every 6 months. We recorded 6-min walk distance, baseline S pO 2 , lowest S pO 2 , and the time to S pO 2 < 90%. In each control, stable patients with severe hypoxia at rest who required long-term oxygen therapy were identified. RESULTS: Upon completion of the study, 65% of the early desaturators had developed severe hypoxemia and required long-term home oxygen, versus 11% in the non-early desaturators (P < .001). CONCLUSIONS: In patients with moderate to severe COPD, desaturation within the first minute of the 6-min walk test predicts the need for long-term home oxygen at 5-year follow-up.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Time to Desaturation Less Than One Minute Predicts the Need for Long-Term Home Oxygen Therapy

et al. 2011

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“…Only the patients who exhibit desaturation within the first minute of the walk test, the so-called early desaturators, also experience desaturation during their daily activities [10]. Those who desaturate past 3.5 min, the late desaturators, do not undergo desaturation in their daily life activities.…”

Section: Short Communicationmentioning

confidence: 99%

Ambulatory Oxygen Therapy in COPD Patients with Oxygen Desaturation during Exercise

García‐Talavera¹,

Figueira‐Gonçalves²

2017

Chron Obstruct Pulmon Dis

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Desaturation during exercise is no longer an anecdote or medical curiosity but has converted into a marker of poor prognosis. Patients with COPD who undergo rapid or early desaturation during the six-minute walking test will have major clinical repercussions than those with late-onset desaturation. Only the patients who exhibit desaturation within the first minute of the walk test, the so-called early desaturators, also experience desaturation during their daily activities. Those who desaturate past 3.5 min, the late desaturators, do not undergo desaturation in their daily life activities. Moreover, the former will require longterm oxygen therapy sooner than the late-onset group.

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“…Garcia-Talavera et al showed that COPD patients with moderate hypoxemia at rest did not have important desaturations during daytime activities if they did not desaturate during the first 3.5 min of a 6-min walk test. 34 Predicting Which Patients May Have Exercise Desaturation. Patients with predominantly an emphysematous phenotype and a lower diffusion capacity are more likely to desaturate during exertion, compared to patients with a similar degree of air-flow obstruction but an airway predominant rather than emphysema predominant phenotype.…”

Section: Exercisementioning

confidence: 99%

Ambulatory Home Oxygen: What Is the Evidence for Benefit, and Who Does It Help?

Criner

2012

Respir Care

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The beneficial effects of ambulatory home oxygen have been demonstrated since the 1950s, when Cotes and Gibson gave oxygen to ambulatory COPD patients from small portable high pressures cylinders in the United Kingdom. Over the ensuing 7 decades, oxygen has been prescribed to millions of COPD patients in the home setting. Additionally, it is common clinical practice to prescribe supplemental oxygen when chronic hypoxemic respiratory failure not due to COPD (eg, interstitial lung disease, pulmonary hypertension, kyphoscoliosis, and cystic fibrosis) is present or in patients with hypoxemia at hospital discharge following flares of their underlying chronic respiratory disorder, without any substantial evidence. Despite the importance of long-term oxygen therapy in clinical home management, there are many gaps in our current knowledge regarding its mechanisms of action, indications for prescription, and its effects on important patient outcomes. Research conducted in the 1970s and 1980s still provides the basis for clinical decision making and insurance coverage policies regarding long-term oxygen administration. Remarkably, little current research is being conducted to extend our knowledge regarding the indications, mechanisms, and benefits of long-term oxygen therapy. This review will focus on our current knowledge of the end points for supplemental oxygen at home, such as mortality, effects on functional performance, sensation of dyspnea, cognitive function, and quality of life, and highlight areas where future research is needed.

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Time to desaturation in the 6-min walking distance test predicts 24-hour oximetry in COPD patients with a PO2 between 60 and 70mmHg

Cited by 36 publications

References 26 publications

Time to Desaturation Less Than One Minute Predicts the Need for Long-Term Home Oxygen Therapy

Time to Desaturation Less Than One Minute Predicts the Need for Long-Term Home Oxygen Therapy

Ambulatory Oxygen Therapy in COPD Patients with Oxygen Desaturation during Exercise

Ambulatory Home Oxygen: What Is the Evidence for Benefit, and Who Does It Help?

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