Time to see: How temporal identity factors specify the developing mammalian retina

Santos-França, Pedro L.; David, Luke Ajay; Kassem, Fatima; Meng, Xiang Qi; Cayouette, Michel

doi:10.1016/j.semcdb.2022.06.003

Cited by 7 publications

(3 citation statements)

References 76 publications

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“…The retina constitutes an excellent model to examine an isolated neural network that is separated from the rest of the central nervous system (CNS), and to investigate the basic concepts of developmental biology. Abundant studies have shown that numerous genes, transcription factors, and neurotrophic factors are involved in the differentiation and formation of the vertebrate retina, acting at specific stages of the development [ 1 , 2 , 3 , 4 , 5 , 6 ]. The retinal neurons and Müller glia are generated in sequential but overlapping waves [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Retinal Development in a Precocial Bird Species, the Quail (Coturnix coturnix, Linnaeus 1758)

Álvarez-Hernán

Mera-Rodríguez

Calle-Guisado

et al. 2023

Cells

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The quail (Coturnix coturnix, Linnaeus 1758), a notable model used in developmental biology, is a precocial bird species in which the processes of retinal cell differentiation and retinal histogenesis have been poorly studied. The purpose of the present research is to examine the retinogenesis in this bird species immunohistochemically and compare the results with those from previous studies in precocial and altricial birds. We found that the first PCNA-negative nuclei are detected at Stage (St) 21 in the vitreal region of the neuroblastic layer, coinciding topographically with the first αTubAc-/Tuj1-/Isl1-immunoreactive differentiating ganglion cells. At St28, the first Prox1-immunoreactive nuclei can be distinguished in the vitreal side of the neuroblastic layer (NbL), but also the first visinin-immunoreactive photoreceptors in the scleral surface. The inner plexiform layer (IPL) emerges at St32, and the outer plexiform layer (OPL) becomes visible at St35—the stage in which the first GS-immunoreactive Müller cells are distinguishable. Newly hatched animals show a well-developed stratified retina in which the PCNA-and pHisH3-immunoreactivies are absent. Therefore, retinal cell differentiation in the quail progresses in the stereotyped order conserved among vertebrates, in which ganglion cells initially appear and are followed by amacrine cells, horizontal cells, and photoreceptors. Müller glia are one of the last cell types to be born. Plexiform layers emerge following a vitreal-to-scleral gradient. Finally, our results suggest that there are no significant differences in the timing of different events involved in retinal maturation between the quail and the chicken, but the same events are delayed in an altricial bird species.

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Section: Introductionmentioning

confidence: 99%

Retinal Development in a Precocial Bird Species, the Quail (Coturnix coturnix, Linnaeus 1758)

Álvarez-Hernán

Mera-Rodríguez

Calle-Guisado

et al. 2023

Cells

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“… 16 , 17 Pioneering studies in model organisms have yielded fundamental insights into transcriptional networks that control the development of retinal cells, especially photoreceptors. 18 – 25 Remarkable spatiotemporal coordination of differentiation and stratification of retinal cell types are undoubtedly more complex in humans and other primates that include a distinct avascular central region, called fovea, which is designed for high visual acuity. 26 , 27 Notably, the fovea and its surrounding macula develop more rapidly compared with the peripheral retina in humans.…”

Section: Introductionmentioning

confidence: 99%

Stage-specific dynamic reorganization of genome topology shapes transcriptional neighborhoods in developing human retinal organoids

Qu,

Batz,

Singh

et al. 2023

Cell Reports

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“…Although omics studies revealed the cellular heterogeneity of adult and developmental retina, the specific temporal and topographic patterning of the generation of their different cell types from RPCs is still under study. It was recently discovered that specific temporal factors in RPCs ensured the generation of different cell types at a given time point [ 55 ]. However, those works were performed in the whole retina or in the central and peripheral retina, but the cell potency of RPCs was not focused on the CM.…”

Section: Introductionmentioning

confidence: 99%

Cell Fate of Retinal Progenitor Cells: In Ovo UbC-StarTrack Analysis

Olmos-Carreño

Figueres-Oñate

Scicolone

et al. 2022

IJMS

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Clonal cell analysis outlines the ontogenic potential of single progenitor cells, allowing the elucidation of the neural heterogeneity among different cell types and their lineages. In this work, we analyze the potency of retinal stem/progenitor cells through development using the chick embryo as a model. We implemented in ovo the clonal genetic tracing strategy UbC-StarTrack for tracking retinal cell lineages derived from individual progenitors of the ciliary margin at E3.5 (HH21-22). The clonal assignment of the derived-cell progeny was performed in the neural retina at E11.5-12 (HH38) through the identification of sibling cells as cells expressing the same combination of fluorophores. Moreover, cell types were assessed based on their cellular morphology and laminar location. Ciliary margin derived-cell progenies are organized in columnar associations distributed along the peripheral retina with a limited tangential dispersion. The analysis revealed that, at the early stages of development, this region harbors multipotent and committed progenitor cells.

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Time to see: How temporal identity factors specify the developing mammalian retina

Cited by 7 publications

References 76 publications

Retinal Development in a Precocial Bird Species, the Quail (Coturnix coturnix, Linnaeus 1758)

Retinal Development in a Precocial Bird Species, the Quail (Coturnix coturnix, Linnaeus 1758)

Stage-specific dynamic reorganization of genome topology shapes transcriptional neighborhoods in developing human retinal organoids

Cell Fate of Retinal Progenitor Cells: In Ovo UbC-StarTrack Analysis

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