Timelotem - an Antipsychotic Benzodiazepine Derivative

Lack of Antagonism by Ro 15-1788 on Timelotem (KC 7507) - a Benzodiazepine with Antipsychotic and Anxiolytic Properties

“…The findings of this study that neither the anxiolytic nor the antipsychotic or CNS depressant effects of TIM are elicited by direct interaction with central benzodiazepine receptors (no antagonism with Ro 15-1788) are in accordance with the lack of in vitro binding to benzodiazepine receptors (Ruhland et al, 1986) and with the absence of muscle relaxant or anticonvulsive properties for this class of compounds (Ruhland et al, 1985). Thus -although structurally a [1,4 ]benzodiazepine --it is most unlikely that TIM, a potential antipsychotic compound with additional anxiolytic activity is interacting directly with central benzodiazepine receptors.…”