Timing of brain-derived neurotrophic factor exposure affects life expectancy of new neurons

Alvarez-Borda, Benjamı́n; Haripal, Bhagwattie; Nottebohm, Fernando

doi:10.1073/pnas.0308118101

Cited by 46 publications

(37 citation statements)

References 27 publications

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“…Rasika et al (22) found that T treatment of adult female canaries increases the synthesis of BDNF protein in HVC, and increased levels of HVC BDNF increase neuronal recruitment. In addition, the timing of BDNF exposure affects the life expectancy of new neurons (23). T withdrawal may thus decrease BDNF trophic support in HVC and lead to a decrease in HVC neuron number (A. M. Wissman and E.A.B., unpublished data).…”

Section: Discussionmentioning

confidence: 99%

Rapid seasonal-like regression of the adult avian song control system

Thompson

Bentley²,

Brenowitz

2007

Proc. Natl. Acad. Sci. U.S.A.

101

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We analyzed how rapidly avian song control nuclei regress after testosterone (T) withdrawal. Regression of neuronal attributes resulting from T withdrawal has been observed in several animal models. The time course over which regression occurs is not known, however. To address this issue, we castrated adult male white-crowned sparrows and rapidly shifted them to short-day photoperiods after being held under breeding conditions (longday photoperiod and systemic T exposure) for 3 weeks. We found that the volume of one song nucleus, HVC, regressed 22% within 12 h after T withdrawal. Changes in HVC neuron density after T withdrawal were dynamic; density increased at 12 h and then decreased by 4 days. HVC neuron number was reduced by 26% by 4 days. The volumes of Area X and the robust nucleus of the arcopallium (RA) were significantly regressed by 7 and 20 days, respectively. RA somatic area and neuronal spacing were significantly reduced by 2 days. The rapidity of HVC regression is unprecedented among vertebrate models of hormone-sensitive neural circuits. These results reveal that the rapid regression of the song control system provides a model for the important role sex steroid hormones play in mediating adult neural plasticity and in neuroprotection.birdsong ͉ neurodegeneration ͉ neuroprotection ͉ plasticity ͉ testosterone

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Section: Discussionmentioning

confidence: 99%

Rapid seasonal-like regression of the adult avian song control system

Thompson

Bentley²,

Brenowitz

2007

Proc. Natl. Acad. Sci. U.S.A.

101

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“…Infusion of rBDNF into HVC 14 -20 d after the birth of new neurons increased the number of neurons that survived for at least 8 mo. Birds that were infused with BDNF either 4 -10 or 24 -30 d after birth, however, showed the typical die-off of 50% of new HVC neurons by 4 mo Alvarez-Borda et al 2004). These observations suggest that T-induced expression of BDNF increases the survival of newly generated neurons in HVC, and that there is a sensitive period soon after new neurons first reach HVC when BDNF has this effect on neuronal survival.…”

Section: Interactions Of Steroid Hormones and Neurotrophinsmentioning

confidence: 99%

Neurogenesis in the Adult Avian Song-Control System

Brenowitz

Larson

2015

Cold Spring Harb Perspect Biol

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New neurons are added throughout the forebrain of adult birds. The song-control system is a model to investigate the addition of new long-projection neurons to a cortical circuit that regulates song, a learned sensorimotor behavior. Neuroblasts destined for the song nucleus HVC arise in the walls of the lateral ventricle, and wander through the pallium to reach HVC. The survival of new HVC neurons is supported by gonadally secreted testosterone and its downstream effectors including neurotrophins, vascularization, and electrical activity of postsynaptic neurons in nucleus RA (robust nucleus of the arcopallium). In seasonal species, the HVC!RA circuit degenerates in nonbreeding birds, and is reconstructed by the incorporation of new projection neurons in breeding birds. There is a functional linkage between the death of mature HVC neurons and the birth of new neurons. Various hypotheses for the function of adult neurogenesis in the song system can be proposed, but this remains an open question.

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“…However, it is not clear whether the ectopically recruited neurons also display a correct phenotype of the surrounding area or whether they are functionally integrated. Furthermore, administration of BDNF during a limited time window increases the lifetime expectancy of neurons in the HVC of adult canaries (Alvarez-Borda et al 2004).…”

Section: Induced Proliferation and Neurogenesis In The Adult Cnsmentioning

confidence: 99%

Proliferation, neurogenesis and regeneration in the non-mammalian vertebrate brain

Kaslin

Ganz

Brand

2007

Phil. Trans. R. Soc. B

319

302

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Post-embryonic neurogenesis is a fundamental feature of the vertebrate brain. However, the level of adult neurogenesis decreases significantly with phylogeny. In the first part of this review, a comparative analysis of adult neurogenesis and its putative roles in vertebrates are discussed. Adult neurogenesis in mammals is restricted to two telencephalic constitutively active zones. On the contrary, non-mammalian vertebrates display a considerable amount of adult neurogenesis in many brain regions. The phylogenetic differences in adult neurogenesis are poorly understood. However, a common feature of vertebrates (fish, amphibians and reptiles) that display a widespread adult neurogenesis is the substantial post-embryonic brain growth in contrast to birds and mammals. It is probable that the adult neurogenesis in fish, frogs and reptiles is related to the coordinated growth of sensory systems and corresponding sensory brain regions. Likewise, neurons are substantially added to the olfactory bulb in smell-oriented mammals in contrast to more visually oriented primates and songbirds, where much fewer neurons are added to the olfactory bulb. The second part of this review focuses on the differences in brain plasticity and regeneration in vertebrates. Interestingly, several recent studies show that neurogenesis is suppressed in the adult mammalian brain. In mammals, neurogenesis can be induced in the constitutively neurogenic brain regions as well as ectopically in response to injury, disease or experimental manipulations. Furthermore, multipotent progenitor cells can be isolated and differentiated in vitro from several otherwise silent regions of the mammalian brain. This indicates that the potential to recruit or generate neurons in non-neurogenic brain areas is not completely lost in mammals. The level of adult neurogenesis in vertebrates correlates with the capacity to regenerate injury, for example fish and amphibians exhibit the most widespread adult neurogenesis and also the greatest capacity to regenerate central nervous system injuries. Studying these phenomena in non-mammalian vertebrates may greatly increase our understanding of the mechanisms underlying regeneration and adult neurogenesis. Understanding mechanisms that regulate endogenous proliferation and neurogenic permissiveness in the adult brain is of great significance in therapeutical approaches for brain injury and disease.

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Timing of brain-derived neurotrophic factor exposure affects life expectancy of new neurons

Cited by 46 publications

References 27 publications

Rapid seasonal-like regression of the adult avian song control system

Rapid seasonal-like regression of the adult avian song control system

Neurogenesis in the Adult Avian Song-Control System

Proliferation, neurogenesis and regeneration in the non-mammalian vertebrate brain

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