Timing temporal transitions during brain development

Rossi, Anthony; Fernandes, Vilaiwan M; Desplan, Claude

doi:10.1016/j.conb.2016.11.010

Cited by 85 publications

(72 citation statements)

References 55 publications

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“…Fourth, the Wnt7 ligand provides a feedback signal from newly-born neurons to cortical progenitors to trigger a switch from neurogenesis to gliogenesis [18]. Additional examples are reviewed elsewhere [19-22]. Thus, many aspects of vertebrate neural temporal patterning are regulated by extrinsic signals.…”

Section: Temporal Patterning In Mammalian and Drosophila Neural Progementioning

confidence: 99%

Playing Well with Others: Extrinsic Cues Regulate Neural Progenitor Temporal Identity to Generate Neuronal Diversity

2017

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During neurogenesis, vertebrate and Drosophila progenitors change over time as they generate a diverse population of neurons and glia. Vertebrate neural progenitors have long been known to use both progenitor-intrinsic and progenitor-extrinsic cues to regulate temporal patterning. In contrast, virtually all temporal patterning mechanisms discovered in Drosophila neural progenitors (neuroblasts) involve progenitor-intrinsic temporal transcription factor cascades. Recent results, however, have revealed several extrinsic pathways that regulate Drosophila neuroblast temporal patterning: nutritional cues regulate the timing of neuroblast proliferation/quiescence and a steroid hormone cue that is required for temporal transcription factor expression. Here we discuss newly discovered extrinsic cues regulating neural progenitor temporal identity in Drosophila, highlight conserved mechanisms, and raise open questions for the future.

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Section: Temporal Patterning In Mammalian and Drosophila Neural Progementioning

confidence: 99%

Playing Well with Others: Extrinsic Cues Regulate Neural Progenitor Temporal Identity to Generate Neuronal Diversity

2017

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“…Embryonic type I neuroblasts have short lineages averaging five neuroblast divisions, and they sequentially express five temporal transcription factors: Hunchback, Krüppel, Pdm (the co-expressed Nubbin and Pdm2 proteins), Castor (Cas), and Grainy head (reviewed in Kohwi and Doe [2013]; Maurange and Gould [2005]; Rossi et al [2017]). In addition, the orphan nuclear hormone receptor Seven-up (Svp) acts as a ‘switching factor’ required for a timely Hunchback-Krüppel transition (Kanai et al, 2005; Mettler et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Steroid hormone induction of temporal gene expression in Drosophila brain neuroblasts generates neuronal and glial diversity

Syed

Mark

Doe

2017

eLife

136

133

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An important question in neuroscience is how stem cells generate neuronal diversity. During Drosophila embryonic development, neural stem cells (neuroblasts) sequentially express transcription factors that generate neuronal diversity; regulation of the embryonic temporal transcription factor cascade is lineage-intrinsic. In contrast, larval neuroblasts generate longer ~50 division lineages, and currently only one mid-larval molecular transition is known: Chinmo/Imp/Lin-28+ neuroblasts transition to Syncrip+ neuroblasts. Here we show that the hormone ecdysone is required to down-regulate Chinmo/Imp and activate Syncrip, plus two late neuroblast factors, Broad and E93. We show that Seven-up triggers Chinmo/Imp to Syncrip/Broad/E93 transition by inducing expression of the Ecdysone receptor in mid-larval neuroblasts, rendering them competent to respond to the systemic hormone ecdysone. Importantly, late temporal gene expression is essential for proper neuronal and glial cell type specification. This is the first example of hormonal regulation of temporal factor expression in Drosophila embryonic or larval neural progenitors.DOI: http://dx.doi.org/10.7554/eLife.26287.001

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“…The temporal regulation of NB proliferation and progeny fate has been well studied in the embryo and larva, and many key factors have been identified (Li et al, 2013;Rossi et al, 2017). The developmental progression of larval NBs is characterised by the levels of two conserved RNA-binding proteins (RBPs), IGF2 mRNA-binding protein (Imp/IGF2BP2) and Imp in the brain and identify myc mRNA among the top 15 targets of Imp.…”

Section: Introductionmentioning

confidence: 99%

Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability

Samuels

Järvelin

Ish‐Horowicz

et al. 2019

Preprint

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The numerous neurons and glia that form the brain originate from tightly controlled growth and division of neural stem cells, regulated systemically by known extrinsic signals. However, the intrinsic mechanisms that control the characteristic proliferation rates of individual neural stem cells are unknown. Here, we show that the size and division rates of Drosophila neural stem cells (neuroblasts) are controlled by the highly conserved RNA binding protein Imp (IGF2BP), via one of its top binding targets in the brain, myc mRNA. We show that Imp stabilises myc mRNA leading to increased Myc protein levels, larger neuroblasts, and faster division rates. Declining Imp levels throughout development limit myc mRNA stability to restrain neuroblast growth and division, while heterogeneous Imp expression correlates with myc mRNA stability between individual neuroblasts in the brain. We propose that Imp-dependent regulation of myc mRNA stability fine-tunes individual neural stem cell proliferation rates.

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Timing temporal transitions during brain development

Cited by 85 publications

References 55 publications

Playing Well with Others: Extrinsic Cues Regulate Neural Progenitor Temporal Identity to Generate Neuronal Diversity

Playing Well with Others: Extrinsic Cues Regulate Neural Progenitor Temporal Identity to Generate Neuronal Diversity

Steroid hormone induction of temporal gene expression in Drosophila brain neuroblasts generates neuronal and glial diversity

Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability

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