Timothy grass pollen major allergen Phl p 1 activates respiratory epithelial cells by a non‐protease mechanism

Röschmann, Kristina; Farhat, Katja; König, Peter; Suck, Roland; Ulmer, Artur J.; Petersen, Arnd

doi:10.1111/j.1365-2222.2009.03291.x

Cited by 34 publications

(32 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, microarray analysis revealed that Timothy grass pollen extract induces elevation of IL-8 expression in NCI-H292 cells, a mucoepidermoid carcinoma cell line derived from human lungs [25]. Human airway epithelial cell secrete IL-8 following incubation timothy grass pollen allergen [26], and this IL-8 secretion in bronchial epithelial cells from not only subjects with uncontrolled asthma, but healthy volunteers [27]. Allergenic pollens have intrinsic NADPH oxidases, and these NADPH oxidases raised oxidized glutathione (GSSG) and 4-hydroxynonenal (4-HNE) in BAL fluids of challenged mice.…”

Section: Pollen Allergenic Extracts Stimulate Cxcl Chemokines and Recmentioning

confidence: 99%

Neutrophil recruitment by allergens contribute to allergic sensitization and allergic inflammation

Hosoki

Itazawa

Boldogh

et al. 2016

Current Opinion in Allergy &Amp; Clinical Immunology

View full text Add to dashboard Cite

Purpose of review To discuss the presence and role of neutrophils in asthma and allergic diseases, and outline importance of pollen and cat dander-induced innate neutrophil recruitment in induction of allergic sensitization and allergic inflammation. Recent findings Uncontrolled asthma is associated with elevated numbers of neutrophils, and levels of neutrophil-attracting chemokine IL-8 and IL-17 in BAL fluids. These parameters negatively correlate with lung function. Pollen allergens and cat dander recruit neutrophils to the airways in a TLR4, MD2 and CXCR2-dependent manner. Repeated recruitment of activated neutrophils by these allergens facilitates allergic sensitization and airway inflammation. Inhibition of neutrophil recruitment with CXCR2 inhibitor, disruption of TLR4, or siRNA against MD2 also inhibits allergic inflammation. The molecular mechanisms by which neutrophils shift the inflammatory response of the airways to inhaled allergens to an allergic phenotype is an area of active research. Summary Recent studies have revealed that neutrophil recruitment is important in development of allergic sensitization and inflammation. Inhibition of neutrophils recruitment may be strategy to control allergic inflammation.

show abstract

Section: Pollen Allergenic Extracts Stimulate Cxcl Chemokines and Recmentioning

confidence: 99%

Neutrophil recruitment by allergens contribute to allergic sensitization and allergic inflammation

Hosoki

Itazawa

Boldogh

et al. 2016

Current Opinion in Allergy &Amp; Clinical Immunology

View full text Add to dashboard Cite

show abstract

“…Remarkably, pathogenesis of birch pollen allergy was associated with the hypo-responsiveness of EC derived from allergic donors [73]. Natural purified major timothy grass pollen allergen Phl p 1 was able to induce pro-inflammatory cytokines secretion from alveolar A549 cells [74]. The authors excluded any proteolytic activity and speculated the induction of TGF-ß and p38 MAPK to have an indirect effect on epithelial integrity.…”

Section: Interaction Of Non-proteases With Ecmentioning

confidence: 99%

What makes an allergen?

Scheurer

Toda

Vieths

2015

Clin Experimental Allergy

View full text Add to dashboard Cite

SummaryAllergic diseases are an immune disorder reacting to certain type of allergen(s). Remarkably only a small number of proteins of the plant and animal proteome act as allergens. Therefore, allergens have been clustered according to their common structural, biochemical and functional features. Evidence has accumulated that some allergens possess intrinsic adjuvant properties to stimulate the innate immunity. The adjuvant properties appear to contribute to the allergenicity of the respective proteins, namely the ability to cause allergic sensitization in susceptible subjects or allergic reactions in sensitized individuals. Here, we discuss how allergens interact with the innate immune cells, in particular dendritic cells and epithelial cells, via binding to pattern recognition receptors, exhibiting proteolytic activities and/or inducting type 2 innate lymphoid cells (ILC2), thereby contributing to the sensitization and development of allergic diseases.

show abstract

“…Interleukin-8 is a major neutrophil chemoattract chemokine. Phl p 1 induces interleukin-8 secretion from human airway epithelial cells independently of its protease activity [46]. Likewise, timothy grass pollen extracts induce interleukin-8 secretion in bronchial epithelial cells from healthy volunteers and patients with severe asthma [31].…”

Section: Innate Immune Responses Induced By Pollen Extractsmentioning

confidence: 99%

Innate responses to pollen allergens

Hosoki

Boldogh

Sur

2015

Current Opinion in Allergy &Amp; Clinical Immunology

View full text Add to dashboard Cite

Purpose of review The aim of the present review was to discuss the effects of pollen components on innate immune responses. Recent findings Pollens contain numerous factors that can stimulate an innate immune response. These include intrinsic factors in pollens such as nicotinamide adenine dinucleotide phosphate oxidases, proteases, aqueous pollen proteins, lipids, and antigens. Each component stimulates innate immune response in a different manner. Pollen nicotinamide adenine dinucleotide phosphate oxidases induce reactive oxygen species generation and recruit neutrophils that stimulate subsequent allergic inflammation. Pollen proteases damage epithelial barrier function and increase antigen uptake. Aqueous pollen extract proteins and pollen lipids modulate dendritic cell function and induce Th2 polarization. Clinical studies have shown that modulation of innate immune response to pollens with toll-like receptor 9- and toll-like receptor 4-stimulating conjugates is well tolerated and induces clear immunological effects, but is not very effective in suppressing primary clinical endpoints of allergic inflammation. Summary Additional research on innate immune pathways induced by pollen components is required to develop novel strategies that will mitigate the development of allergic inflammation.

show abstract

Timothy grass pollen major allergen Phl p 1 activates respiratory epithelial cells by a non‐protease mechanism

Cited by 34 publications

References 37 publications

Neutrophil recruitment by allergens contribute to allergic sensitization and allergic inflammation

Neutrophil recruitment by allergens contribute to allergic sensitization and allergic inflammation

What makes an allergen?

Innate responses to pollen allergens

Contact Info

Product

Resources

About