TIMP-1 Expression in Human Colorectal Cancer Is Associated with SMAD3 Gene Expression Levels: A Pilot Study

Braicu, Elena Ioana; Ionescu, Călin; Chiorean, Roxana; Cojocneanu, Roxana; Neagoe, E.; Pop, Laura; Chira, Sergiu; Berindan‐Neagoe, Ioana

doi:10.15403/jgld.2014.1121.234.smad

Cited by 19 publications

(17 citation statements)

References 30 publications

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“…These adhesion molecules are retrieved in the circulatory system and not only at tumor sites, especially in advanced stages [ 49 , 50 , 51 ]. These adhesion effectors and angiogenic markers could thus be used as biomarkers of invasion and metastasis [ 49 , 50 , 52 , 53 , 54 , 55 ]. Immune and inflammation-related genes may provide a better understanding of the mechanisms through which tobacco smoking causes disease [ 56 ], as well as the possible benefits of immune agonist therapy.…”

Section: Discussionmentioning

confidence: 99%

Differential Effect of Smoking on Gene Expression in Head and Neck Cancer Patients

Irimie

Braicu

Cojocneanu

et al. 2018

IJERPH

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Smoking is a well-known behavior that has an important negative impact on human health, and is considered to be a significant factor related to the development and progression of head and neck squamous cell carcinomas (HNSCCs). Use of high-dimensional datasets to discern novel HNSCC driver genes related to smoking represents an important challenge. The Cancer Genome Atlas (TCGA) analysis was performed in three co-existing groups of HNSCC in order to assess whether gene expression landscape is affected by tobacco smoking, having quit, or non-smoking status. We identified a set of differentially expressed genes that discriminate between smokers and non-smokers or based on human papilloma virus (HPV)16 status, or the co-occurrence of these two exposome components in HNSCC. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways classification shows that most of the genes are specific to cellular metabolism, emphasizing metabolic detoxification pathways, metabolism of chemical carcinogenesis, or drug metabolism. In the case of HPV16-positive patients it has been demonstrated that the altered genes are related to cellular adhesion and inflammation. The correlation between smoking and the survival rate was not statistically significant. This emphasizes the importance of the complex environmental exposure and genetic factors in order to establish prevention assays and personalized care system for HNSCC, with the potential for being extended to other cancer types.

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Section: Discussionmentioning

confidence: 99%

Differential Effect of Smoking on Gene Expression in Head and Neck Cancer Patients

Irimie

Braicu

Cojocneanu

et al. 2018

IJERPH

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“…The coalescent response of integrin–ECM–GF interactions inside the tumor microenvironment promotes the activation and localization of RAS to the inner membrane. Moreover, ECM regulates intercellular communication, cell junction plasticity, and cell adhesion molecules that interact with a wide range of cytokines/chemokine or growth factors [5,69,72,73]. Among the most studied integrin-mediated signaling effectors in cancer cells are the non-receptor tyrosine kinases focal adhesion kinase (FAK) and Src integrins that are linked to downstream signaling effectors such as the Rac1 GTPase and MAPK [74].…”

Section: Implications Of the Tumor Microenvironment In Regulating mentioning

confidence: 99%

A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer

Braicu

Buse

Busuioc

et al. 2019

Cancers

649

444

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The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch from extracellular signals to intracellular responses. Alterations of signaling cascades are found in various diseases, including cancer, as a result of genetic and epigenetic changes. Numerous studies focused on both the homeostatic and the pathologic conduct of MAPK signaling; however, there is still much to be deciphered in terms of regulation and action models in both preclinical and clinical research. MAPK has implications in the response to cancer therapy, particularly the activation of the compensatory pathways in response to experimental MAPK inhibition. The present paper discusses new insights into MAPK as a complex cell signaling pathway with roles in the sustenance of cellular normal conduit, response to cancer therapy, and activation of compensatory pathways. Unfortunately, most MAPK inhibitors trigger resistance due to the activation of compensatory feed-back loops in tumor cells and tumor microenvironment components. Therefore, novel combinatorial therapies have to be implemented for cancer management in order to restrict the possibility of alternative pathway activation, as a perspective for developing novel therapies based on integration in translational studies.

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“…Evidence suggests that MUC expression is involved in the invasion and metastasis of various malignancies, including gallbladder cancer [19], breast cancer [20], ovarian cancer [21], gastric carcinoma [22,23], pancreatic carcinoma [24][25][26], ampullary cancer [27,28], lung cancer [16,29], prostate cancer [30], renal cell carcinoma [31], and appendiceal carcinoma [32]. However, the prognostic value of MUC expression in CRC remains controversial [33][34][35][36][37]. To clarify the inconsistent findings from previously published studies investigating the role of MUC in CRC, this meta-analysis was conducted to assess the association between MUC expression levels and prognosis in CRC and investigate the associations between MUC expression levels and several CRC clinicopathological characteristics.…”

Section: Introductionmentioning

confidence: 99%

Prognostic and Clinicopathological Significance of MUC Family Members in Colorectal Cancer: A Systematic Review and Meta-Analysis

Zuo

Liu

et al. 2019

Gastroenterology Research and Practice

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Objective. To assess the association between MUC expression levels in colorectal cancer (CRC) tissues and prognosis and investigate the associations between MUC expression levels and CRC clinicopathological characteristics. Methods. The PubMed, Embase, Cochrane Library, and Web of Science databases were searched from inception through September 13, 2019, to identify studies investigating the association between MUC expression levels in CRC tissues and prognosis. Pooled hazard ratios (HRs) or odds ratio (ORs) with 95% confidence intervals (CIs) were used to evaluate associations between MUC expression levels and prognosis or clinicopathological characteristics, respectively. The heterogeneity between studies was assessed by the I2 values, whereas the likelihood of publication bias was assessed by Egger’s linear regression and Begg’s rank correlation test. Results. Among 33 included studies (n=6032 patients), there were no associations between combined MUC phenotype expression levels and overall survival (OS) or disease-free survival (DFS)/relapse-free survival (RFS) in patients with CRC. In subgroup analyses, the upregulated MUC1 expression (HR=1.50; 95% CI, 1.29–1.74; P<0.00001) was associated with poor OS. However, the upregulated MUC2 expression (HR=0.64; 95% CI, 0.52–0.79; P<0.00001) was associated with better OS. Furthermore, a high level of MUC1 expression (HR=1.99; 95% CI, 0.99–3.99; P=0.05) was associated with shorter DFS/RFS. However, patients with a low level of MUC2 tumors showed better DFS/RFS than patients with a high level of MUC2 tumors (HR=0.71; 95% CI, 0.49–1.04; P=0.08; P=0.0.009, I2=67%) and MUC5AC expression (HR=0.56; 95% CI, 0.38–0.82; P=0.003) was associated with longer DFS/RFS. In addition, a high level of MUC1 expression was associated with CRC in the rectum, deeper invasion, lymph node metastasis, distant metastasis, advanced tumor stage, and lymphatic invasion. A high level of MUC2 expression had a protective effect. High secretion of MUC5AC is associated with colon cancer compared with rectal cancer. Conclusion. The protein expression of MUC1 might be a poor biomarker in colorectal cancer and might play a role in tumor transformation and metastasis. However, the protein expression of MUC2 expression might have a protective effect. Furthermore, randomized controlled trials (RCTs) of large patients are needed to confirm the results.

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TIMP-1 Expression in Human Colorectal Cancer Is Associated with SMAD3 Gene Expression Levels: A Pilot Study

Cited by 19 publications

References 30 publications

Differential Effect of Smoking on Gene Expression in Head and Neck Cancer Patients

Differential Effect of Smoking on Gene Expression in Head and Neck Cancer Patients

A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer

Prognostic and Clinicopathological Significance of MUC Family Members in Colorectal Cancer: A Systematic Review and Meta-Analysis

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