Tinea capitis in children: a systematic review of management

Gupta, Aditya K.; Mays, Rachel; Versteeg, Sarah G.; Piraccini, Bianca Maria; Shear, Neil H.; Piguet, Vincent; Tosti, Antonella; Friedlander, Sheila Fallon

doi:10.1111/jdv.15088

Cited by 109 publications

(129 citation statements)

References 49 publications

(164 reference statements)

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“…Terbinafine was the only agent to have a higher complete cure rate of 92% [16]. However, griseofulvin was superior in treating infections caused by Microsporum species [16, 17]. Hence, longer courses of griseofulvin sometimes were required to cure infections caused by M. canis [1].…”

Section: Griseofulvinmentioning

confidence: 99%

“…According to a recent systematic review, griseofulvin maintains a high complete cure rate of 72% [16]. Terbinafine was the only agent to have a higher complete cure rate of 92% [16].…”

Section: Griseofulvinmentioning

confidence: 99%

“…Terbinafine was the only agent to have a higher complete cure rate of 92% [16]. However, griseofulvin was superior in treating infections caused by Microsporum species [16, 17].…”

Section: Griseofulvinmentioning

confidence: 99%

“…It comes in three formulations: oral solution, capsule, and tablets. The recommended dose for tinea capitis is 5 mg/kg/day (Table 4), and the duration varies based on causative agent: 2–4 weeks for T. tonsurans and 4–6 weeks for M. canis [1, 16]. For young children, the capsule can be opened or chewed.…”

Section: Itraconazolementioning

confidence: 99%

“…According to a systemic review and a meta-analysis, itraconazole and terbinafine are the most effective agents in treating Trichophyton infections and have a similar efficacy [16, 40]. A study has found terbinafine for 2 weeks to be superior in treating T. tonsurans when compared to 2 weeks of itraconazole (91.1 vs 80%) [50], while in another study, 2 weeks of itraconazole was found to be superior in treating T. violaceum than 2 weeks of terbinafine [51].…”

Section: Itraconazolementioning

confidence: 99%

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Treatment of Tinea Capitis

Alkeswani

Cantrell²,

Elewski

2019

Skin Appendage Disord

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Tinea capitis is a common fungal infection of the hair of the scalp affecting predominately prepubertal children. In the US, griseofulvin has been considered a first-line therapy agent for tinea capitis since the 1960s. However, it has been falling out of favor due to significant treatment failure, high cost, and long duration of treatment. Other antifungal agents have been researched as an alternative to griseofulvin. This paper will review the relevant pharmacologic properties, dosing, cost, efficacy, and adverse events profile for griseofulvin, terbinafine, itraconazole, fluconazole, and some adjuvant therapy options such as selenium sulfide shampoos and topical ketoconazole.

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Section: Griseofulvinmentioning

confidence: 99%

“…According to a recent systematic review, griseofulvin maintains a high complete cure rate of 72% [16]. Terbinafine was the only agent to have a higher complete cure rate of 92% [16].…”

Section: Griseofulvinmentioning

confidence: 99%

“…Terbinafine was the only agent to have a higher complete cure rate of 92% [16]. However, griseofulvin was superior in treating infections caused by Microsporum species [16, 17].…”

Section: Griseofulvinmentioning

confidence: 99%

Section: Itraconazolementioning

confidence: 99%

Section: Itraconazolementioning

confidence: 99%

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Treatment of Tinea Capitis

Alkeswani

Cantrell²,

Elewski

2019

Skin Appendage Disord

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Tinea capitis (Favus) in a 8‐year‐old child: Case report

Akbari,

Parhiz,

Sabzi

2024

Clinical Case Reports

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Key Clinical MessageIn examining any scalp itch or skin lesions, especially in children with long hair, fungal lesions under the hair may not be diagnosed in a timely manner. Additionally, fungal infection of the scalp, known as tinea capitis, is considered a chronic condition and if left untreated, it can lead to alopecia (hair loss) and permanent scarring.AbstractTinea capitis (TC) is a common cutaneous fungal infection in childhood. In this report, we describe the case of an 8‐year‐old child presenting with erythematous scalp lesions accompanied by hair loss. Upon examination, palpation revealed a swollen and tender left parotid gland. Notably, the frontal region of the scalp exhibited erythematous lesions and scaly red plaques resembling yellowish paste‐like dough. Subsequent clinical evaluation and culture analysis confirmed the diagnosis of TC. The patient received treatment with Terbinafine 125 mg for a duration of 8 weeks. Follow‐up examinations conducted after 3 months showed no signs of recurrence. Accurate diagnosis and timely treatment, along with adherence to medication regimens, are crucial in cases of TC, and differential diagnoses should be considered. Treatment should commence promptly upon diagnosis to prevent complications such as scalp baldness and transmission to others. This case report underscores the significance of establishing a precise diagnosis and effective treatment for this dermatophytosis to mitigate the risk of recurrences or therapeutic shortcomings, particularly in infants.

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