Tinea capitis: ringworm of the scalp

Seebacher, C; Abeck, Dietrich; Brasch, Jochen; Cornely, Oliver A.; Daeschlein, Georg; Effendy, Isaak; Ginter‐Hanselmayer, Gabriele; Haake, Norbert; Hamm, Gudrun; Hipler, C; Hof, Herbert; Körting, Hans Christian; Kramer, Axel; Mayser, Peter; Ruhnke, Markus; Schlacke, Kurt-Heiner; Tietz, H.-J.

doi:10.1111/j.1439-0507.2006.01350.x

Cited by 39 publications

(65 citation statements)

References 26 publications

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“…Either dermatophyte can cause tinea capitis in children requiring systemic treatment, according to guidelines. Yet while terbinafi ne is effective against A. benhamiae (terbinafi ne may be prescribed in children in Germany as a treatment attempt according to the German pharmaceutical law), it is much less effective against M. canis, and hence griseofulvin, fl uconazole, and itraconazole (in children as a treatment attempt according to the German pharmaceutical law) are the recommended drugs of choice [8,9]. We evaluated whether chromogenic media, as used in microbiology for the differentiation between bacteria and yeast [10,11], could enable rapid differentiation of these dermatophytes.…”

Section: Introductionmentioning

confidence: 99%

A simple and rapid method to differentiate Arthroderma benhamiae from Microsporum canis

Mayser

Budihardja

2012

J Deutsche Derma Gesell

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In addition to searching for the origin of infection (in A. benhamiae almost exclusively guinea pigs, and for M. canis dogs and cats), distinguishing between the Trichophyton and Microsporum genera is most important, especially for the selection of a systemic antimycotic agent in the treatment of tinea capitis in children. In the case of M. canis terbinafine is not the first choice, but rather griseofulvin, fluconazole or itraconazole. We present a method of differentiation using Candi-Select(TM) 4. When done with a primary culture, this allows for presumptive identification within a few hours and thus prompt initiation of pathogen-specific therapy.

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Section: Introductionmentioning

confidence: 99%

A simple and rapid method to differentiate Arthroderma benhamiae from Microsporum canis

Mayser

Budihardja

2012

J Deutsche Derma Gesell

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“…2,3 The compound was, until the approval of Terbinafine 4 by the US Food and Drug Administration 5 in 2007, the only drug available for treatment of tinea capitis, 6 a superficial fungal skin infection caused by dermatophytes, which predominantly affects children. 7 Upon administration to man, griseofulvin accumulates in the skin (stratum corneum), where it presumably binds to keratin. 8 The mode of action is still not determined, but tubulin binding has been proposed.…”

Section: ■ Introductionmentioning

confidence: 99%

Disparate SAR Data of Griseofulvin Analogues for the Dermatophytes Trichophyton mentagrophytes, T. rubrum, and MDA-MB-231 Cancer Cells

et al. 2012

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Griseofulvin and 53 analogues of this compound have been tested against the pathogenic dermatophytes Trichophyton rubrum and Trichophyton mentagrophytes as well as against the breast cancer cell line MDA-MB-231. The modifications to griseofulvin include the 4, 5, 6, 2′, 3′, and 4′ positions. The SAR of the griseofulvin analogues toward the two fungi followed the same trend with the majority being less active than griseofulvin and none had more than twice the potency of the parent compound. A comparison of the antifungal and the anticancer SAR revealed distinct differences, as the majority of analogues showed increased activity against the cancer cell line MDA-MB-231, highlighted by 2′-benzyloxy-2′-demethoxy-griseofulvin, which showed low activity against both fungi but was among the most potent compounds against MDA-MB-231 cancer cells. Tubulin has been proposed as the target of griseofulvin in both fungal and mammalian cells, but the differences revealed by this SAR study strongly suggest that the mode-of-action of the compound class toward fungi and mammalian cancer cells is different.

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“…Mikroskobik muayenede kıl kökü ve deri kazıntılarının incelenmesi ve lezyonlu materyalde hifa ve sporların görülmesi pratikte yardımcı olmaktadır (10,12,15,17,33). Kesin tanı fungal kültürle yapılır ve bu amaçla çoğunlukla Sabouraud Dekstroz Agar kullanılır.…”

Section: Introductionunclassified

“…Ekim yapılan besiyerleri 2-4 hafta arasında inkübasyona bırakılır ve üreyen mantarların mikroskobik ve makroskobik morfolojileri incelenir. Bazen üreaz aktivitesi gibi biyokimyasal veya in vitro saç penetrasyon testi gibi fizyolojik testlerin uygulanması gerekebilir (12,27,33).…”

Section: Introductionunclassified

KEDİ ve KÖPEKLERDEN DERMATOFİTLERİN İZOLASYONU

Yapıcıer¹,

Şababoğlu²,

Öztürk³

et al. 2017

Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi

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ISOLATION OF DERMATOPHYTES FROM CATS AND DOG ABSTRACTDermatophytosis is an infectious and zoonotic disease caused by fungal agents that affect the keratin layer of hair follicles, nails and epidermis. The causative agents of dermatophytosis are Microsporum, Trichophyton and Epidermophyton species. In this study, a total of 102 skin scarpings and hair samples taken from cats and dogs with suspected dermatophytosis between 2013 and 2017 at different seasons were investigated. The mycological analyses were conducted by direct microscopy and fungal culture on Sabouraud Dextrose Agar. Fifty six out of 102 samples were positive for dermatophytosis. Five (24.83%) Microsporum sp. and 3 (12.50 %) Trichophyton sp. were isolated from 24 materials taken from the cats. Fourty seven (60.25%) Microsporum sp. and 1 (1.28%) Trichophyton sp. were diagnosed from 78 dog based materials. The occurrence of dermatophytosis cases was mostly observed in the spring (82.75%), followed by autumn (64.28%) and summer (38.88%) seasons in cats and dogs. .

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Tinea capitis: ringworm of the scalp

Abstract: The guideline tinea capitis, as passed by three German medical societies, is presented in the present study.

Cited by 39 publications

References 26 publications

A simple and rapid method to differentiate Arthroderma benhamiae from Microsporum canis

A simple and rapid method to differentiate Arthroderma benhamiae from Microsporum canis

Disparate SAR Data of Griseofulvin Analogues for the Dermatophytes Trichophyton mentagrophytes, T. rubrum, and MDA-MB-231 Cancer Cells

KEDİ ve KÖPEKLERDEN DERMATOFİTLERİN İZOLASYONU

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