Tinospora cordifolia extract prevents cadmium-induced oxidative stress and hepatotoxicity in experimental rats

Baskaran, Rathinasamy; Priya, Lohanathan Bharathi; Kumar, Vijay; Padma, Viswanadha Vijaya

doi:10.1016/j.jaim.2017.07.005

Cited by 28 publications

(14 citation statements)

References 52 publications

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“…Superoxide dismutase (SOD) is an antioxidant enzyme which catalyzes the dismutation of superoxide anions (O 2-) into H2O2 and molecular oxygen (21). It plays important protective roles against cellular and histological damage induced by ROS.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of anti-oxidative properties of <i>Tinosporacordifoliain Alloxan</i> induced diabetic Wistar rats

Thakur¹,

Padmadeo²,

Kumar³

2021

Biomedicine

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Introduction and Aim: Type 2 Diabetes is a complex heterogenous disorder with marked hyperglycemia, reduced insulin sensitivity, increased oxidative stress, and altered carbohydrate, fat and protein metabolism. Increased oxidative stress is a key factor for the reduced pancreatic ? cell arose due to prolonged hyperglycemia. The present investigation admits ethanolic extract of Tinosporacordifolia (250mg/kg/body weight) as a potent antihyperglycemic agent as well as antioxidant. Materials and methods: Wistar norvegicus rats of 180-200 gm were involved in the present study divided in to 5 groups. Each group has 5 rats. Diabetes was induced by Alloxan (100mg/kg.b.wt). Administration of T.cordifolia (250mg/kg/b.wt) done in the desired group for 10,20, and 30 days respectively. Fasting blood collected for plasma glucose and the organs were collected for the antioxidant assay. Results: Each group showed significant recovery in the glucose and antioxidant parameters like Glutathione, Catalase, Ascorbate etc., Statistical analysis was done by Tukey multiple range test compared with entire column after ANOVA. Level of significance was denoted for diabetic Vs treated group having p values *** p<0.05, **p<0.01, *p<0.001, NS-Non-significant, >0.05. Conclusion: Relying on the Herbal extract of T.cordifolia would be one of the best options for controlling glucose concentration, enhanced immunity, and getting rid of unnecessary free radicals which increases aging. The plant under investigation is a reservoir of countless secondary metabolites.

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Section: Discussionmentioning

confidence: 99%

Evaluation of anti-oxidative properties of <i>Tinosporacordifoliain Alloxan</i> induced diabetic Wistar rats

Thakur¹,

Padmadeo²,

Kumar³

2021

Biomedicine

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“…Excellent antioxidant properties were reported with the ethanolic and n-butanol fractions of T. cordifolia extracts [34]. They have been shown to stabilize the antioxidant status of heart [35], liver and kidney [30,36,37] and inhibit the superoxide, hydroxyl radicals and lipid peroxidation. Studies showed that the methanolic extracts of T. cordifolia-stems prevented cadmium-induced cardiotoxicity, hepatotoxicity and nephrotoxicity by their antioxidant activity via modulation on the cellular antioxidant status of antioxidant enzymes such as superoxide dismutase, catalase, glutathione-s-transferase, glutathione peroxidase and GSH levels [30,35,37].…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…4 Therapeutic Properties T. cordifolia T. cordifolia has been reported to have antioxidant, anticancer, radio protective, antidiabetic, antidote, antimicrobial, antiallergic, antihyperglycemic, antileprotic, anti-inflammatory, antihyperlipidemic and immunomodulatory properties [30].…”

Section: Chemical Compositionmentioning

confidence: 99%

Therapeutic Potential of the Medicinal Plant Tinospora cordifolia–Minireview

Priya¹,

Balasubramanian²,

Shanmugaraj³

et al. 2022

Phyton

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For thousands of years, plant based herbal medicines have been utilized by millions of people all over the world. Plant materials or products are used in different folk/traditional medical systems, such as the Chinese, African and Indian medical systems, like Siddha, Ayurveda, Unani, and Homeopathy. Tinospora cordifolia (TC) is a medicinal plant belonging to the family Menispermaceae. It is a big deciduous, climbing shrub growing prevalently in the tropical part of Indian subcontinent regions such as India, Pakistan, Nepal, Bhutan, Bangladesh and Srilanka, and in Myanmar, and China. Guduchi, Giloy, Shindilkodi, and Amritha are all the common names for this plant. Extracts from different parts of this herbal plant have been used to treat many diseases. In Ayurvedic medicine, extract from this plant is used for preparing "rasayanas", which is known to cure diabetes, skin diseases, allergic conditions, jaundice, cardiovascular diseases, rheumatoid arthritis, poisoning, and microbial infections. T. cordifolia has a many bioactive phytochemicals that have been isolated from its aerial parts and roots. Many bioactive principles have been reported from this plant which belong to various classes like alkaloids, aliphatic compounds, diterpenoid lactones, phenolics, flavonoids, glycosides, sesquiterpenoids, lignans, steroids and polysaccharides. T. cordifolia possesses medicinal properties such as antioxidant, antiallergic, antiinflammatory, antimicrobial, antiviral, antidote, antitumor, antileprotic, antispasmodic, and antidiabetic properties. The present review will provide a comprehensive therapeutic potential of T. cordifolia.

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“…The individual effect of guduchi (Tinospora cardifolia) against carbon tetrachloride-induced hepatic damage, cadmium induce oxidative stress and hepatotoixicity [12] and gentamycininduced renal toxicity has been studied [13,14]. Similarly, the individual effect of punarnava (Boerhavia diffusa) on gentamicin-induced nephrotoxicity and thioacetamide intoxicated rats has been studied [15,16].…”

Section: Introductionmentioning

confidence: 99%

Research Protocol for Assessment of Solitary and Combined effect of Guduchi and Punarnava on Structural and Functional Changes of Ageing in Liver and Kidney in Wistar Rats

Tawalare

Dandekar

Desai

et al. 2021

JPRI

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Background: The liver and kidney play a central role in metabolic and detoxification processes leads to structural degeneration of organs with aging, which may hamper the functional ability of these organs. Acharya charaka suggests to use drugs of vayasthapana mahakashaya in different combinations to prevent ageing. Guduchi (Tinospora cardifolia) and punarnava (Boerhavia diffusa) are two drugs chosen to evaluate the solitary and combined effect on structural and functional changes in liver and kidney of Wistar rat. Materials and Methods: After identification and phytochemical study of test drugs, the 32 healthy, male rats of 18 months will be divided into four different groups, with eight rats in each group. 1st to 4th group will receive distilled water, guduchi kwath, punarnava kwath, guduchi and punarnava kwath respectively for 30 consecutive days at the rate of 8.1ml/kg dose, orally. Before administration of control drug and test drug blood sample assessment will be done for LFT, KFT, and SOD level. The same investigation will be repeated after one month trial period. Then after 60 days,120 days and 180 days, two animals from each group will be sacrificed, organs such as liver and kidney will be extracted and preserved for histopathological study, and blood samples will be collected for investigation. The remaining animals will be returned to the animal house for their reuse. Expected Results: Guduchi and punarnava may provide strength to liver and kidney and thus helpful in delaying degenerative changes of organs.

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Tinospora cordifolia extract prevents cadmium-induced oxidative stress and hepatotoxicity in experimental rats

Cited by 28 publications

References 52 publications

Evaluation of anti-oxidative properties of <i>Tinosporacordifoliain Alloxan</i> induced diabetic Wistar rats

Evaluation of anti-oxidative properties of <i>Tinosporacordifoliain Alloxan</i> induced diabetic Wistar rats

Therapeutic Potential of the Medicinal Plant Tinospora cordifolia–Minireview

Research Protocol for Assessment of Solitary and Combined effect of Guduchi and Punarnava on Structural and Functional Changes of Ageing in Liver and Kidney in Wistar Rats

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