TiO
            <sub>2</sub>
            nanoparticles: green synthesis, characterization, and investigation of antimicrobial properties, and developmental toxicity in zebrafish (
            <i>Danio rerio</i>
            ) embryos

Subramanian, Rajaduraipandian; Ponnanikajamideen, M.; Rajendran, R. Samuel; Alshehri, Mohammed Ali; Alasmari, Abdulrahman; Panneerselvam, Chellasamy; Periyasamy, Selvendiran

doi:10.1080/01480545.2023.2217697

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…A spectral peak observed at 1041 cm À 1 attributed to the stretching of the carbon-oxygen (CÀ O) bond in amino acid. [45,46] The presence of peaks at the wavenumber of 422 cm À 1 confirmed the presence of TiO 2 NPs, as reported in reference. [31,47] 2.4.…”

Section: Ftirsupporting

confidence: 81%

Green Biosynthesis of TiO₂Nanoparticles Using Aqueous Extract ofBrassica juncea(L.) Czern Seed: Characterization, Antimicrobial, Antioxidant and Anticancer Activities

Jeyaraj,

Mary Saral

2024

ChemistrySelect

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Primary objective of this research was to examine the biogenic production of TiO2 NPs using Brassica juncea (L.) Czern seed and investigate the prospective uses of thus synthesized nanoparticles in the area of biomedicine. The synthesized TiO2 NPs were subjected to characterization using several analytical methods namely TEM, UV‐vis, XRD, FE‐SEM, FTIR and EDAX. The average particle size (TEM) is found to be 38 nm, exhibiting irregular shapes. The FT‐IR spectra indicated that the extract contains functional groups, such as polyphenolic, hydroxyl and carboxylic groups, which are likely responsible for formation of nanoparticles. The cytotoxicity studies of the synthesized TiO2 NPs against breast cancer cells (MCF‐7) and lung cells (A549) are shown to be dosage dependent. The inhibitory doses (IC50) were determined to be 43.98 μg/mL and 74.50 μg/mL on MCF‐7 and A549 cells, respectively. Green synthesized TiO2 NPs were assessed for antioxidant activity inhibition rate (DPPH 89.42 %). TiO2 NPs exhibited a maximal zone of inhibition of Staphylococcus aureus 23±0.20 mm against and 20±0.30 against Klebsiella pneumoniae at a concentration of 100 μg/mL, indicating strong antibacterial activity. The findings suggest Brassica juncea (L.) Czern seed encapsulated TiO2 NPs possesses excellent biological applications which can be explored for its application in pharmaceutical field.

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Section: Ftirsupporting

confidence: 81%

Green Biosynthesis of TiO₂Nanoparticles Using Aqueous Extract ofBrassica juncea(L.) Czern Seed: Characterization, Antimicrobial, Antioxidant and Anticancer Activities

Jeyaraj,

Mary Saral

2024

ChemistrySelect

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“…Recent investigations have extensively explored nanocarriers such as dendrimers, liposomes, nanotubes, and nanoparticles. Researchers have focused on their structural characteristics, size manipulation, and selective diagnosis using disease imaging molecules, ushering in a paradigm shift in drug delivery [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

Petrovic,

Bita,

Barbinta-Patrascu

2024

IJMS

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This study provides a brief discussion of the major nanopharmaceuticals formulations as well as the impact of nanotechnology on the future of pharmaceuticals. Effective and eco-friendly strategies of biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) are outlined. This paper discusses the need to use natural resources for the “green” design of new nanoformulations with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, and the preparation of nanomaterials must be carefully considered. Therefore, safety and long-term effects of pharmaceutical nanoformulations must not be overlooked. The testing of nanopharmaceuticals represents an essential point in their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent a valuable, bioinspired model for nanopharmaceutical testing that avoids using animals. Nanoformulations are critical in various fields, especially in pharmacy, medicine, agriculture, and material science, due to their unique properties and advantages over conventional formulations that allows improved solubility, bioavailability, targeted drug delivery, controlled release, and reduced toxicity. Nanopharmaceuticals have transitioned from experimental stages to being a vital component of clinical practice, significantly improving outcomes in medical fields for cancer treatment, infectious diseases, neurological disorders, personalized medicine, and advanced diagnostics. Here are the key points highlighting their importance. The significant challenges, opportunities, and future directions are mentioned in the final section.

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Biotoxicity of Acrostichum aureum L. synthesized zinc oxide nanoparticles against Aedes albopictus, and impact on predation efficiency of mosquito fish Gambusia affinis

Roni

Harilal

2023

Inorganic Chemistry Communications

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TiO ₂ nanoparticles: green synthesis, characterization, and investigation of antimicrobial properties, and developmental toxicity in zebrafish ( Danio rerio ) embryos

Cited by 5 publications

References 28 publications

Green Biosynthesis of TiO₂Nanoparticles Using Aqueous Extract ofBrassica juncea(L.) Czern Seed: Characterization, Antimicrobial, Antioxidant and Anticancer Activities

Green Biosynthesis of TiO₂Nanoparticles Using Aqueous Extract ofBrassica juncea(L.) Czern Seed: Characterization, Antimicrobial, Antioxidant and Anticancer Activities

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

Biotoxicity of Acrostichum aureum L. synthesized zinc oxide nanoparticles against Aedes albopictus, and impact on predation efficiency of mosquito fish Gambusia affinis

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TiO 2 nanoparticles: green synthesis, characterization, and investigation of antimicrobial properties, and developmental toxicity in zebrafish ( Danio rerio ) embryos

Cited by 5 publications

References 28 publications

Green Biosynthesis of TiO2Nanoparticles Using Aqueous Extract ofBrassica juncea(L.) Czern Seed: Characterization, Antimicrobial, Antioxidant and Anticancer Activities

Green Biosynthesis of TiO2Nanoparticles Using Aqueous Extract ofBrassica juncea(L.) Czern Seed: Characterization, Antimicrobial, Antioxidant and Anticancer Activities

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

Biotoxicity of Acrostichum aureum L. synthesized zinc oxide nanoparticles against Aedes albopictus, and impact on predation efficiency of mosquito fish Gambusia affinis

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Product

Resources

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TiO ₂ nanoparticles: green synthesis, characterization, and investigation of antimicrobial properties, and developmental toxicity in zebrafish ( Danio rerio ) embryos

Green Biosynthesis of TiO₂Nanoparticles Using Aqueous Extract ofBrassica juncea(L.) Czern Seed: Characterization, Antimicrobial, Antioxidant and Anticancer Activities

Green Biosynthesis of TiO₂Nanoparticles Using Aqueous Extract ofBrassica juncea(L.) Czern Seed: Characterization, Antimicrobial, Antioxidant and Anticancer Activities