Tip-enhanced Raman Spectroscopy – Its status, challenges and future directions

Yeo, Boon Siang; Stadler, Johannes; Schmid, Thomas; Zenobi, Renato; Zhang, Weihua

doi:10.1016/j.cplett.2009.02.023

Cited by 236 publications

(225 citation statements)

References 96 publications

Supporting

Mentioning

215

Contrasting

Unclassified

Order By: Relevance

“…This is not ideal as the silver film on the tips also degrade with time, though recent work has shown approaches for increasing the yield by oxidizing the silicon of the AFM probes before silver deposition [349] see Figure 28(i) , and by storage in inert environments [350]. Etching of Ag wires is very common for STM-TERS tip fabrication [351], although this method has been used for some AFM-TERS setups, particularly those that use shear-force feedback instead of tapping-mode AFM [352]. With the etching approach, as no distinct nanoparticle is present, the radius of curvature of the end of the tip is often used to approximate the size of the plasmon particle.…”

Section: Typical Systemmentioning

confidence: 99%

Raman spectroscopy: techniques and applications in the life sciences

Shipp¹,

Sinjab²,

Notingher³

2017

Adv. Opt. Photon.

268

189

View full text Add to dashboard Cite

Raman spectroscopy is an increasingly popular technique in many areas including biology and medicine.It is based on Raman scattering, a phenomenon in which incident photons lose or gain energy via interactions with vibrating molecules in a sample. These energy shifts can be used to obtain information regarding molecular composition of the sample with very high accuracy. Applications of Raman spectroscopy in the life sciences have included quantification of biomolecules, hyperspectral molecular imaging of cells and tissue, medical diagnosis, and others. This review briefly presents the physical origin of Raman scattering explaining the key classical and quantum mechanical concepts. Variations of the Raman effect will also be considered, including resonance, coherent, and enhanced Raman scattering. We discuss the molecular origins of prominent bands often found in the Raman spectra of biological samples. Finally, we examine several variations of Raman spectroscopy techniques in practice, looking at their applications, strengths, and challenges. This review is intended to be a starting resource for scientists new to Raman spectroscopy, providing theoretical background and practical examples as the foundation for further study and exploration.

show abstract

Section: Typical Systemmentioning

confidence: 99%

Raman spectroscopy: techniques and applications in the life sciences

Shipp¹,

Sinjab²,

Notingher³

2017

Adv. Opt. Photon.

268

189

View full text Add to dashboard Cite

show abstract

“…They claimed that they can attain SM sensitivity because the Raman band from brilliant cresyl blue shows fluctuations in intensity and to a minor extent also in frequency [83,86], which is a possible indicator for SM behaviour as discussed in §2 (the characteristics of SM-SERS). Another popular dye used for SM-TERS study is malachite green isothiocyanate [58,87,88], which has a strong adsorption band centred around the excitation line at 632.8 nm and exhibits strong fluorescence as reported by Domke et al [89].…”

Section: Devices/systems For Single-molecule Surfaceenhanced Raman Spmentioning

confidence: 99%

“…Therefore, dyes are a specific class of molecules for SM-SERS or SM-TERS investigation because of the resonance contribution. However, TERS has also demonstrated SM sensitivity in detecting small molecules such as biological samples (DNA strands, proteins and membranes) [83,90]. It should be pointed out that the key indicators to achieve SM-TERS are the modification/fabrication of the tips and the controlled distance between the tips and the substrate with molecule adsorption [83].…”

Section: Devices/systems For Single-molecule Surfaceenhanced Raman Spmentioning

confidence: 99%

“…However, TERS has also demonstrated SM sensitivity in detecting small molecules such as biological samples (DNA strands, proteins and membranes) [83,90]. It should be pointed out that the key indicators to achieve SM-TERS are the modification/fabrication of the tips and the controlled distance between the tips and the substrate with molecule adsorption [83]. For example, Zhang et al [86] proved the near-field property of TERS by recording the distance dependence of TERS, which exhibits a strong signal increase when the tip -sample distance is lowered below 30 nm.…”

Section: Devices/systems For Single-molecule Surfaceenhanced Raman Spmentioning

confidence: 99%

See 1 more Smart Citation

Surface-enhanced Raman spectroscopy at single-molecule scale and its implications in biology

Wang

Irudayaraj

2013

Phil. Trans. R. Soc. B

106

View full text Add to dashboard Cite

Single-molecule (SM) spectroscopy has been an exciting area of research offering significant promise and hope in the field of sensor development to detect targets at ultra-low levels down to SM resolution. To the experts and developers in the field of surface-enhanced Raman spectroscopy (SERS), this has often been a challenge and a significant opportunity for exploration. Needless to say, the opportunities and excitement of this multidisciplinary area impacts span the fields of physics, chemistry and engineering, along with a significant thrust in applications constituting areas in medicine, biology, environment and agriculture among others. In this review, we will attempt to provide a quick snapshot of the basics of SM-SERS, nanostructures and devices that can enable SM Raman measurement. We will conclude with a discussion on SERS implications in biomedical sciences.

show abstract

“…In one of the highest efficiency organic solar cells, for instance (P3HT: PCBM bulk HJ), the efficiency limitations due to lower cutoff wavelength (∼650 nm/E G ∼2.1 eV) was taken care of by enhancing optical absorption as reported [43][44][45][46][47][48][49][50][51][52][53][54][55].…”

Section: Metal and Semiconductor Npsmentioning

confidence: 99%

Green Intelligent Nanomaterials by Design (Using Nanoparticulate/2D-Materials Building Blocks) Current Developments and Future Trends

Kumar¹,

Ahmad²

2017

Nanoscaled Films and Layers

View full text Add to dashboard Cite

Feasibility of designing and synthesizing 'smart' and 'intelligent' materials using nanostructured building blocks has been examined here based on the current status of the progress made in this context. The added advantages of using 2D layered/nonlayered materials along with phytosomal species derived from natural plants are highlighted with special reference to their better programmability along with minimum toxicity in biomedical applications. The current developments taking place in their upscaled productions are also included while assessing their upcoming industrial usages in diverse fields.

show abstract

Tip-enhanced Raman Spectroscopy – Its status, challenges and future directions

Cited by 236 publications

References 96 publications

Raman spectroscopy: techniques and applications in the life sciences

Raman spectroscopy: techniques and applications in the life sciences

Surface-enhanced Raman spectroscopy at single-molecule scale and its implications in biology

Green Intelligent Nanomaterials by Design (Using Nanoparticulate/2D-Materials Building Blocks) Current Developments and Future Trends

Contact Info

Product

Resources

About