TIPE attenuates the apoptotic effect of radiation and cisplatin and promotes tumor growth via JNK and p38 activation in Raw264.7 and EL4 cells

Liu, Yao; Xiao, Ni; Chen, Rui Ling; Li, Juan; Gao, Feng

doi:10.3892/or.2018.6351

Cited by 2 publications

(2 citation statements)

References 31 publications

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“…The family comprises four members: TIPE, TIPE1, TIPE2 and TIPE3 ( 9 ). TIPE2 has been demonstrated to be a negative regulator of inflammation and cellular immunity ( 10 , 11 ), whereas TIPE expression is downregulated in several malignances, such as lung cancer, and is associated with a favorable patient prognosis ( 12 , 13 ). TIPE1 is considered a cell death inducer in both normal and cancer cells ( 12 , 13 ).…”

Section: Introductionmentioning

confidence: 99%

“…TIPE2 has been demonstrated to be a negative regulator of inflammation and cellular immunity ( 10 , 11 ), whereas TIPE expression is downregulated in several malignances, such as lung cancer, and is associated with a favorable patient prognosis ( 12 , 13 ). TIPE1 is considered a cell death inducer in both normal and cancer cells ( 12 , 13 ). Downregulated TIPE1 expression has been observed in hepatocellular carcinoma ( 14 ), lung cancer ( 15 ) and gastric cancer ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

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TIPE1 impairs ovarian tumor growth by promoting caspase-dependent apoptosis

Deng

et al. 2020

Oncol Lett

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Tumor necrosis factor-α-induced protein 8-like 1 (TIPE1) functions as a tumor suppressor in several types of cancer, including lung and breast cancer. The present study aimed to determine the level of expression and the function of TIPE1 in ovarian cancer. TIPE1 expression was determined in tissue microarrays and ovarian cancer cells, and these data were analyzed to assess the association between TIPE1 expression and prognosis in patients with ovarian cancer. The potential antitumor effects of TIPE1 were investigated in vitro and in a xenograft mouse model. Furthermore, the underlying molecular mechanism by which TIPE1 regulates ovarian cancer growth was determined via flow cytometric analysis, western blotting and rescue experiments. The results of the present study indicated that TIPE1 levels were markedly decreased in ovarian cancer tissues, and its level of expression was associated with a favorable prognosis of patients with ovarian cancer. In addition, ectopic TIPE1 expression significantly impaired A2780 and SKOV3 cell proliferation and colony formation in vitro , which was accompanied by efficient inhibition of xenograft tumor growth in mice. Investigations into the underlying molecular mechanism demonstrated that TIPE1 induced ovarian cancer cell apoptosis by promoting caspase protein expression. Inhibition of caspase-dependent apoptosis by z-VAD blocked TIPE1-mediated inhibition of the proliferation and induction of apoptosis in ovarian cancer cells. Collectively, the results of the present study suggest that TIPE1 may be a potential prognostic predictor and therapeutic target for patients with ovarian cancer.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

TIPE1 impairs ovarian tumor growth by promoting caspase-dependent apoptosis

Deng

et al. 2020

Oncol Lett

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WSG, a Glucose-Rich Polysaccharide from Ganoderma lucidum, Combined with Cisplatin Potentiates Inhibition of Lung Cancer In Vitro and In Vivo

et al. 2021

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Lung cancer has the highest global mortality rate of any cancer. Although targeted therapeutic drugs are commercially available, the common drug resistance and insensitivity to cisplatin-based chemotherapy, a common clinical treatment for lung cancer, have prompted active research on alternative lung cancer therapies and methods for mitigating cisplatin-related complications. In this study, we investigated the effect of WSG, a glucose-rich, water soluble polysaccharide derived from Ganoderma lucidum, on cisplatin-based treatment for lung cancer. Murine Lewis lung carcinoma (LLC1) cells were injected into C57BL/6 mice subcutaneously and through the tail vein. The combined administration of WSG and cisplatin effectively inhibited tumor growth and the formation of metastatic nodules in the lung tissue of the mice. Moreover, WSG increased the survival rate of mice receiving cisplatin. Co-treatment with WSG and cisplatin induced a synergistic inhibitory effect on the growth of lung cancer cells, enhancing the apoptotic responses mediated by cisplatin. WSG also reduced the cytotoxic effect of cisplatin in both macrophages and normal lung fibroblasts. Our findings suggest that WSG can increase the therapeutic effectiveness of cisplatin. In clinical settings, WSG may be used as an adjuvant or supplementary agent.

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TIPE attenuates the apoptotic effect of radiation and cisplatin and promotes tumor growth via JNK and p38 activation in Raw264.7 and EL4 cells

Cited by 2 publications

References 31 publications

TIPE1 impairs ovarian tumor growth by promoting caspase-dependent apoptosis

TIPE1 impairs ovarian tumor growth by promoting caspase-dependent apoptosis

WSG, a Glucose-Rich Polysaccharide from Ganoderma lucidum, Combined with Cisplatin Potentiates Inhibition of Lung Cancer In Vitro and In Vivo

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