TIPE2 acts as a biomarker for tumor aggressiveness and suppresses cell invasiveness in papillary thyroid cancer (PTC)

Jia, Wenyu; Li, Zequn; Chen, Junyu; Sun, Lei; Liu, Chuanqian; Wang, Shaping; Chi, Jen-Tsan; Ni, Jun; Li, Hong

doi:10.1186/s13578-018-0247-x

Cited by 9 publications

(4 citation statements)

References 38 publications

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“…Ten high-power fields were randomly selected from each specimen to observe and record the percentage of positively stained cells of TIPE2 in tumor cells (0: 0%; 1: 1∼25%; 2: 26∼50%; 3: 51∼75%; 4: 76∼100%) and the corresponding staining intensity (0: no staining; 1: light yellow; 2. Medium tan; 3: dark tan) [ 15 ]. The expression score of TIPE2 was obtained by multiplying the results of the above two scores, which ranged from 0 to 12 points.…”

Section: Methodsmentioning

confidence: 99%

“…Subsequent studies have found that TIPE2 is also involved in multiple signaling pathways of tumorigenesis and development, and plays a key role in different processes of cancer cell survival, proliferation, migration and invasion [ 6 , 7 ]. Among different cancer types, TIPE2 expression level was decreased in liver cancer [ 8 ], small cell lung cancer [ 9 ], stomach cancer [ 10 ], esophageal cancer [ 11 ] and prostate cancer [ 12 ], and increased in kidney cancer [ 13 ], colon cancer [ 14 ] and thyroid papillary carcinoma [ 15 ]. TIPE2 has shown its potential as a novel tumor therapeutic target and biomarker in various cancers.…”

Section: Introductionmentioning

confidence: 99%

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A Novel Prognostic Factor TIPE2 in Bladder Cancer

Jiang¹,

Zhang²,

Wang³

et al. 2022

Pathol. Oncol. Res.

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Objective: We sought to identify tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 (TIPE2/TNFAIP8L2) expression in bladder cancer and its relationship to clinicopathological findings and prognosis.Methods: Immunohistochemical (IHC) staining for TIPE2 was performed on 110 archived radical cystectomy specimens. Ten high-power fields were randomly selected from each specimen to observe and record the percentage of immunoreactive cells of TIPE2 in tumor cells (grade 0–4) and the corresponding immunostaining intensity (grade 0–3). The expression score of TIPE2 was obtained by multiplying the results of the above two scores, which ranged from 0 to 12 points. The cut-off point of the sum of the scores were defined as follows: 0–3 scores were defined as negative expression (-); >3 scores were classified as positive expression, < 7, low expression, ≥7, high expression.Results: In 110 cases, TIPE2 was stained in various degrees in bladder cancer tissues, and expressed in both nucleus and cytoplasm. 4.5% (5/110) showed negative expression, 40.9% (45/110) showed low expression, and 54.5% (60/110) showed high expression. TIPE2 expression was negatively correlated with lymph node metastasis (p = 0.004) and disease progression (p = 0.021). Survival curves were plotted to show that patients with high TIPE2 expression had a progression-free survival curve above those with negative/low TIPE2 expression (p = 0.027). In multivariate Cox proportional hazard regression analysis, TIPE2 was a protective factor for progression-free survival in bladder urothelial carcinoma (p = 0.031), pT stage (p = 0.016) was a risk factor for progression-free survival, and age was a risk factor for overall survival (p = 0.020).Conclusion: TIPE2 may be a new biomarker to predict the disease progression and prognosis of patients with urothelial carcinoma of the bladder.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Novel Prognostic Factor TIPE2 in Bladder Cancer

Jiang¹,

Zhang²,

Wang³

et al. 2022

Pathol. Oncol. Res.

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“…Many reports have shown that the expression of TIPE2 was positively correlated with the Tumor Node Metastasis (TNM) staging in renal cell carcinoma and lymph node metastasis of colon cancer (Zhang et al, 2013). Further, a high expression of TIPE2 was negatively correlated with tumor size, envelope infiltration, peripheral infiltration, and tumor T-stage in thyroid adenocarcinoma (Jia et al, 2018). TIPE2 was more expressed in early-stage tumor tissues than in advancedstage tumor tissues in pancreatic ductal adenocarcinoma (PDAC) (Sun et al, 2021).…”

Section: Tipe Family Structuresmentioning

confidence: 99%

Structure, function, and mechanism of the TNFAIP8 (TIPE) family of proteins in cancer and inflammation

LIN,

TANG,

KANG

et al. 2023

BIOCELL

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The multiple roles of the tumor necrosis factor (TNF)-α-inducible protein 8 (TNFAIP8), also named TIPE family of proteins have been shown in tumor and inflammation progression and regulation of cellular autophagy and apoptosis. In this review, we found that the TIPE family showed highly homologous sequences and conserved functional domains, such as the death effector domain (DED)-like domain but displayed different roles and mechanisms in different biological activities. For example, while TIPE is primarily associated with tumor progression and antitumor drug resistance, TIPE1 suppresses tumor progression in most instances. TIPE2 has multiple roles in tumor progression regulation, and antitumor drug resistance. Moreover, TIPE2 was also involved in inflammatory response regulation, tumor typing, and staging. A few studies reported that TIPE3 was engaged in tumor development by activating the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) signaling pathway. The structure, function, and mechanism of the TIPE family in cancer and inflammation have been summarized in this review. This might serve as a reference for further research on the TIPE family and shed new light on the crosstalk among antitumor responses, inflammation, and immunology.

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“…In the study of papillary thyroid carcinoma (PTC), TIPE2 overexpression was observed in tumor samples, and inhibited viability, proliferation, and invasion of PTC cells. Furthermore, TIPE2 attenuated tumor invasiveness via inhibition of Rac1, resulting in reduced MMP-9 and uPA expression, indicating its crucial role in predicting tumor aggressiveness of PTC 76 ( Table 1 ). In Non-Hodgkin’s lymphoma (NHL), the increased expression of TIPE2 was identified in both peripheral T cell lymphoma and diffuse large B-cell lymphoma (DLBCL), and TIPE2 expression in DLBCL was stronger than that in T lymphoma.…”

Section: Roles Of Tipe2 In Cancersmentioning

confidence: 99%

<p>Regulatory Roles of Tumor Necrosis Factor-α-Induced Protein 8 Like-Protein 2 in Inflammation, Immunity and Cancers: A Review</p>

Gu¹,

Chen²,

Sun³

et al. 2020

CMAR

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Tumor necrosis factor-alpha (TNF-α)-induced protein 8 (TNFAIP8/TIPE) family, including TNFAIP8 (TIPE), TNFAIP8 like-protein 1 (TNFAIP8L1/TIPE1), TNFAIP8 like-protein 2 (TNFAIP8L2/TIPE2), and TNFAIP8 like-protein 3 (TNFAIP8L3/TIPE3), plays a vital role in regulating inflammatory responses, immune homeostasis, and cancer development. Over the last decade, studies have shown that TIPE2 protein is differentially expressed in diverse cells and tissues. The dysregulation of TIPE2 protein can lead to dysregulation of inflammatory responses and immune homeostasis, and change the basic characteristics of cancers. In consideration of the immeasurable values of TIPE2 in diagnosis, treatment, and prognosis of various human diseases, this review will focus on the expression pattern, structure, and regulatory roles of TIPE2 in inflammation, immunity, and cancers.

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TIPE2 acts as a biomarker for tumor aggressiveness and suppresses cell invasiveness in papillary thyroid cancer (PTC)

Cited by 9 publications

References 38 publications

A Novel Prognostic Factor TIPE2 in Bladder Cancer

A Novel Prognostic Factor TIPE2 in Bladder Cancer

Structure, function, and mechanism of the TNFAIP8 (TIPE) family of proteins in cancer and inflammation

<p>Regulatory Roles of Tumor Necrosis Factor-α-Induced Protein 8 Like-Protein 2 in Inflammation, Immunity and Cancers: A Review</p>

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